The role of proline in the proteolytic regulation of biologically active peptides

Biopolymers ◽  
1987 ◽  
Vol 26 (S0) ◽  
pp. S215-S222 ◽  
Author(s):  
A. Yaron
Keyword(s):  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides

Proteases and posttranslational processing of prohormones: a review

1983 ◽  
Vol 61 (7) ◽  
pp. 501-515 ◽  
Author(s):  
Claude Lazure ◽  
Nabil G. Seidah ◽  
Didier Pélaprat ◽  
Michel Chrétien
Keyword(s):  
Amino Acid ◽  
Current Knowledge ◽  
Secretory Granules ◽  
Basic Amino Acid ◽  
Biologically Active ◽  
Maturation Process ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Precursor Molecules

Pioneering work on insulin and on lipotropin, published in 1967, led to the formulation of the hypothesis that biologically active peptides such as peptide hormones are derived from larger precursor molecules by enzymatic cleavage at basic amino acid pairs. Since then, an ever-increasing number of hormones and active peptides including neuropeptides have been found to be contained within the sequence of a larger precursor protein and are released by limited proteolytic cleavage. The hypothesis concerning the posttranslational maturation of precursor molecules into smaller active entities is now firmly established in many tissues (e.g., pituitary gland, pancreas) and for all kinds of organisms (e.g. mammals, fish), though the nature of the enzyme(s) responsible for this maturation process still remains unknown. This article presents current knowledge of the intracellular processing of precursor molecules, especially the conversion of prohormone to hormone. The discussion deals principally with the evidences concerning the localization of the maturation process mainly in the secretory granules, the role of basic amino acid pairs at the cleavage site, and the possible involvement of serine and (or) thiol endopeptidases in that process.

The role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells

2012 ◽  
Vol 1270 (1) ◽  
pp. 93-97 ◽  
Author(s):  
Carlos Cabrera ◽  
Gabriela Carriquiry ◽  
Chiara Pierinelli ◽  
Nancy Reinoso ◽  
Javier Arias-Stella ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Tissue Repair ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides

scholarly journals Concepts for Biologically Active Peptides

2010 ◽  
Vol 16 (30) ◽  
pp. 3390-3400 ◽  
Author(s):  
Abba J. Kastin ◽  
Weihong Pan
Keyword(s):  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides
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