Understanding peptide competitive inhibition of botulinum neurotoxin a binding to SV2 protein via molecular dynamics simulations

Biopolymers ◽  
2015 ◽  
Vol 103 (10) ◽  
pp. 597-608 ◽  
Author(s):  
Shan Chang ◽  
Hong-Qiu He ◽  
Lin Shen ◽  
Hua Wan
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Botulinum Neurotoxin ◽  
Competitive Inhibition ◽  
Botulinum Neurotoxin A ◽  
Dynamics Simulations

Molecular dynamics simulations of wild type and mutants of botulinum neurotoxin A complexed with synaptic vesicle protein 2C

2015 ◽  
Vol 11 (1) ◽  
pp. 223-231 ◽  
Author(s):  
Feng Wang ◽  
Hua Wan ◽  
Jian-ping Hu ◽  
Shan Chang
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Synaptic Vesicle ◽  
Conformational Changes ◽  
Botulinum Neurotoxin ◽  
Wild Type ◽  
Botulinum Neurotoxin A ◽  
Synaptic Vesicle Protein ◽  
Dynamics Simulations ◽  
The Relationship

Using molecular dynamics simulations, we investigate the relationship between the conformational changes of BoNT/A-RBD:SV2C-LD and the interfacial interactions.

Sign in / Sign up

Export Citation Format

Share Document