scholarly journals Solid-phase synthesis of fusaricidin/li-f class of cyclic lipopeptides: Guanidinylation of resin-bound peptidyl amines

Biopolymers ◽  
2013 ◽  
Vol 100 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Nina Bionda ◽  
Jean-Philippe Pitteloud ◽  
Jean-Philippe Pitteloud ◽  
Predrag Cudic
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Cyclic Lipopeptides

scholarly journals Solid-Phase Synthesis of Biaryl Cyclic Lipopeptides Derived from Arylomycins

ACS Omega ◽  
2020 ◽  
Vol 5 (36) ◽  
pp. 23401-23412
Author(s):  
Iteng Ng-Choi ◽  
Eduard Figueras ◽  
Àngel Oliveras ◽  
Lidia Feliu ◽  
Marta Planas
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Cyclic Lipopeptides

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

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