Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens

Biopolymers ◽  
2011 ◽  
Vol 96 (2) ◽  
pp. 193-206 ◽  
Author(s):  
Mark Agostino ◽  
Mauro S. Sandrin ◽  
Philip E. Thompson ◽  
Paul A. Ramsland ◽  
Elizabeth Yuriev
Keyword(s):  
Peptide Inhibitors ◽  
Carbohydrate Antigens ◽  
Xenoreactive Antibodies

S12.7 Carbohydrate antigens as targets for xenoreactive antibodies in a mouse to rat transplantation model

1993 ◽  
Vol 10 (4) ◽  
pp. 297-297
Author(s):  
M. L. Gustavsson ◽  
G. Gannedahl ◽  
A. E. B�cker ◽  
A. Olling ◽  
A. Olling ◽  
...  
Keyword(s):  
Carbohydrate Antigens ◽  
Transplantation Model ◽  
Xenoreactive Antibodies

Peptide Inhibitors of Aspartic Proteinases with Hydroxyethylene Isostere Replacement of Peptide Bond. II. Preparation of Pseudotetrapeptides Derived from Diastereoisomeric 5-Amino-2-benzyl-4-hydroxy-6-phenylhexanoic Acids

1998 ◽  
Vol 63 (4) ◽  
pp. 541-548 ◽  
Author(s):  
Jaroslav Litera ◽  
Jan Weber ◽  
Ivana Křížová ◽  
Iva Pichová ◽  
Jan Konvalinka ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Peptide Bond ◽  
Peptide Inhibitors ◽  
Aspartic Proteinases ◽  
Hiv 1

Twelve pseudotetrapeptides, Boc-NHCH(CH2Ph)CH(OH)CH2CH(CH2Ph) CO-Xaa-Phe-NH2 9-11, were prepared by [(benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphate-mediated couplings of diastereoisomeric O-silylated (2R or 2S,4R or 4S,5S)-2-benzyl-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenylhexanoic acids 1 with dipeptides H-Xaa-Phe-NH2 (Xaa = Gln, Glu(OBzl) or Ile) 3-5, followed by O-deprotection. Pseudotetrapeptides 9-11 were tested for inhibition of aspartic proteinases secreted by Candida albicans and C. tropicalis. The level of inhibition of both yeast proteinases was very low, contrasting with the nanomolar IC50 values obtained for inhibition of HIV-1 proteinase.

scholarly journals Development of Allosteric BRAF Peptide Inhibitors Targeting the Dimer Interface of BRAF

2019 ◽  
Vol 14 (7) ◽  
pp. 1471-1480 ◽  
Author(s):  
Amber Y. Gunderwala ◽  
Anushri A. Nimbvikar ◽  
Nicholas J. Cope ◽  
Zhijun Li ◽  
Zhihong Wang
Keyword(s):  
Peptide Inhibitors ◽  
Dimer Interface

scholarly journals Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity

2020 ◽  
Vol 1 (2) ◽  
pp. 100014 ◽  
Author(s):  
Anja Henning-Knechtel ◽  
Sunil Kumar ◽  
Cecilia Wallin ◽  
Sylwia Król ◽  
Sebastian K.T.S. Wärmländer ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Peptide Inhibitors ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming

2021 ◽  
Author(s):  
Daniel J. Ford ◽  
Nisharnthi M. Duggan ◽  
Sarah E. Fry ◽  
Jorge Ripoll-Rozada ◽  
Stijn M. Agten ◽  
...  
Keyword(s):  
Genetic Code ◽  
Cyclic Peptide ◽  
Peptide Inhibitors ◽  
Mrna Display
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