Structure-activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S

Biopolymers ◽  
2003 ◽  
Vol 71 (1) ◽  
pp. 28-48 ◽  
Author(s):  
Darin L. Lee ◽  
Robert S. Hodges
Keyword(s):  
Antimicrobial Peptides ◽  
De Novo ◽  
Structure Activity Relationships ◽  
Gramicidin S ◽  
Structure Activity

Antimicrobial Peptides and Their Superior Fluorinated Analogues: Structure-Activity Relationships as Revealed by NMR Spectroscopy and MD Calculations

ChemBioChem ◽  
2010 ◽  
Vol 11 (17) ◽  
pp. 2424-2432 ◽  
Author(s):  
M. Dolores Díaz ◽  
Martina Palomino-Schätzlein ◽  
Francisco Corzana ◽  
Cecilia Andreu ◽  
Rodrigo J. Carbajo ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Antimicrobial Peptides ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Structure-Activity Relationships of Diastereomeric Lysine Ring Size Analogs of the Antimicrobial Peptide Gramicidin S

2004 ◽  
Vol 280 (3) ◽  
pp. 2002-2011 ◽  
Author(s):  
Elmar J. Prenner ◽  
Monika Kiricsi ◽  
Masood Jelokhani-Niaraki ◽  
Ruthven N. A. H. Lewis ◽  
Robert S. Hodges ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Ring Size ◽  
Structure Activity Relationships ◽  
Gramicidin S ◽  
Structure Activity

scholarly journals Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases.

1996 ◽  
Vol 43 (1) ◽  
pp. 143-160 ◽  
Author(s):  
N G Johansson ◽  
S Eriksson
Keyword(s):  
De Novo ◽  
Nucleoside Analogs ◽  
Deoxycytidine Kinase ◽  
De Novo Synthesis ◽  
Substrate Specificities ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Deoxyguanosine Kinase ◽  
Alternative Routes ◽  
Deoxyribonucleoside Kinases

The mammalian deoxyribonucleoside kinases thymidine kinase 1 and 2, deoxycytidine kinase and deoxyguanosine kinase phosphorylate deoxyribonucleosides and provide an alternative to de novo synthesis of DNA precursors. Their activities are essential for activation of several chemotherapeutically important nucleoside analogs. These four salvage kinase enzymes exhibit distinct substrate specificities for nucleoside analogs modified in the base and glycon moieties. In this review their. structure-activity relationships are discussed. Alternative routes for phosphorylation of nucleoside analogs are also reviewed, such as the phosphotransfer capacity of 5'-nucleotidase and protein kinases.

Application of ‘HESH’ Descriptors for the Structure-Activity Relationships of Antimicrobial Peptides

2009 ◽  
Vol 16 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Mao Shu ◽  
Yongjun Jiang ◽  
Li Yang ◽  
Yuqian Wu ◽  
Hu Mei ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure–activity relationships of gramicidin S analogs containing (β-3-pyridyl)-α,β-dehydroalanine residues on membrane permeability

MedChemComm ◽  
2011 ◽  
Vol 2 (7) ◽  
pp. 644 ◽  
Author(s):  
Keiichi Yamada ◽  
Makoto Kodaira ◽  
Shun-suke Shinoda ◽  
Keiko Komagoe ◽  
Hiroyuki Oku ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Structure Activity Relationships ◽  
Gramicidin S ◽  
Structure Activity
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