An optimized solid phase synthesis strategy? including on-resin lactamization?of astressin, its retro-, inverso-, and retro-inverso isomers as corticotropin releasing factor antagonists

Biopolymers ◽  
2002 ◽  
Vol 63 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Dirk T. S. Rijkers ◽  
Jack A. J. den Hartog ◽  
Rob M. J. Liskamp
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Corticotropin Releasing Factor ◽  
Phase Synthesis ◽  
Synthesis Strategy

A convenient solid-phase synthesis methodology for preparing peptide-derived molecular imaging agents — Synthesis, characterization, and in vitro screening of Tc(I) – chemotactic peptide conjugates

2005 ◽  
Vol 83 (12) ◽  
pp. 2060-2066 ◽  
Author(s):  
Karin A Stephenson ◽  
Sangeeta Ray Banerjee ◽  
Nicole McFarlane ◽  
Douglas R Boreham ◽  
Kevin P Maresca ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Metal Chelate ◽  
Free Ligand ◽  
Peptide Sequence ◽  
In Vitro Screening ◽  
Chemotactic Peptide ◽  
Phase Synthesis ◽  
Synthesis Strategy

A versatile solid-phase synthesis strategy for preparing peptide–chelate conjugates was developed. The methodology was optimized using a series of ligands, designed to bind Tc(I)/Re(I), and a chemotactic peptide fMFL, which was exploited as a model targeting vector. The peptide derivatives were prepared in parallel using a conventional automated peptide synthesizer in multi-milligram quantities, which provided sufficient material to perform complete characterization, radiolabelling, and in vitro screening studies. Because of the robust nature of the metal–chelate complexes, the Re complex of a chelate–peptide conjugate was prepared on the resin using the same methodology employed to prepare the free ligand conjugates. As such, the reported methodology is amenable to the preparation of libraries of novel Tc radiopharmaceutical ligands and their corresponding Re reference standards in which several factors, including peptide sequence, site of derivatization, and both the type and length of the spacer, can be easily varied.Key words: radiopharmaceuticals, technetium, rhenium, peptides, solid-phase synthesis.

Development of a solid phase synthesis strategy for soluble phosphoinositide analogues

2012 ◽  
Vol 3 (6) ◽  
pp. 1893 ◽  
Author(s):  
Miriam Bru ◽  
Shriram P. Kotkar ◽  
Nilanjana Kar ◽  
Maja Köhn
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Synthesis Strategy

Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy

2006 ◽  
Vol 47 (24) ◽  
pp. 4085-4089 ◽  
Author(s):  
Wei-Yan Shao ◽  
Ying-Nan Cao ◽  
Zhi-Wen Yu ◽  
Wen-Jie Pan ◽  
Xu Qiu ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Curcumin Derivatives ◽  
Synthesis Strategy ◽  
Facile Preparation

Preparation of core 2 type tetrasaccharide carrying decapeptide by benzyl protection-based solid-phase synthesis strategy

2002 ◽  
Vol 43 (46) ◽  
pp. 8395-8399 ◽  
Author(s):  
Yutaka Takano ◽  
Motoki Habiro ◽  
Masaomi Someya ◽  
Hironobu Hojo ◽  
Yoshiaki Nakahara
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Synthesis Strategy

Salt-template-assisted synthesis of robust 3D honeycomb-like structured MoS2 and its application as a lithium-ion battery anode

2016 ◽  
Vol 4 (22) ◽  
pp. 8734-8741 ◽  
Author(s):  
Jingwen Zhou ◽  
Jian Qin ◽  
Naiqin Zhao ◽  
Chunsheng Shi ◽  
En-Zuo Liu ◽  
...  
Keyword(s):  
Lithium Ion Battery ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Lithium Ion ◽  
Lithium Storage ◽  
Phase Synthesis ◽  
Storage Performance ◽  
Synthesis Strategy ◽  
Template Assisted Synthesis ◽  
Battery Anode

3D honeycomb-like structured MoS2 fabricated by a salt template-assisted solid-phase synthesis strategy exhibits excellent lithium storage performance.

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