Metal–Organic Frameworks for Photodynamic Therapy: Emerging Synergistic Cancer Therapy

2020 ◽  
pp. 1900382 ◽  
Author(s):  
Yucong Song ◽  
Lei Wang ◽  
Zhigang Xie
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Metal Organic Frameworks ◽  
Metal Organic

scholarly journals The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

2018 ◽  
Vol 9 ◽  
pp. 2960-2967 ◽  
Author(s):  
Jan Hynek ◽  
Sebastian Jurík ◽  
Martina Koncošová ◽  
Jaroslav Zelenka ◽  
Ivana Křížová ◽  
...  
Keyword(s):  
Inorganic Chemistry ◽  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Biological Applications ◽  
Nanoparticle Surface ◽  
Metal Organic ◽  
Unsaturated Metal Sites ◽  
First Time

Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin. The nanoICR-2/porphyrin composites retain part of the free porphyrins photophysical properties, while the photodynamic efficacy is strongly affected by the R substituent at the porphyrin phosphinate groups. Thus, phosphinatophenylporphyrin with phenyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake.

scholarly journals Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy

Theranostics ◽  
2018 ◽  
Vol 8 (16) ◽  
pp. 4332-4344 ◽  
Author(s):  
Hong-Min Meng ◽  
Xiao-Xiao Hu ◽  
Ge-Zhi Kong ◽  
Chan Yang ◽  
Ting Fu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Targeted Photodynamic Therapy

Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

Biomaterials ◽  
2020 ◽  
Vol 258 ◽  
pp. 120278 ◽  
Author(s):  
Kai Zhang ◽  
Xiangdan Meng ◽  
Zhou Yang ◽  
Haifeng Dong ◽  
Xueji Zhang
Keyword(s):  
Cancer Therapy ◽  
Metal Organic Frameworks ◽  
Copper Metal ◽  
Metal Organic

scholarly journals Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy

Theranostics ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 2791-2799 ◽  
Author(s):  
Yuan Liu ◽  
Christina S. Gong ◽  
Lisen Lin ◽  
Zijian Zhou ◽  
Yijing Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Fluorescence Switch ◽  
Metal Organic

BODIPY-containing nanoscale metal–organic frameworks for photodynamic therapy

2016 ◽  
Vol 52 (31) ◽  
pp. 5402-5405 ◽  
Author(s):  
Weiqi Wang ◽  
Lei Wang ◽  
Zhensheng Li ◽  
Zhigang Xie
Keyword(s):  
Photodynamic Therapy ◽  
Ligand Exchange ◽  
Metal Organic Frameworks ◽  
Metal Organic

BODIPY-immobilized metal–organic frameworks for photodynamic therapy were developed through solvent-assisted ligand exchange.

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