Butanol production from renewable biomass: Rediscovery of metabolic pathways and metabolic engineering

2011 ◽  
Vol 7 (2) ◽  
pp. 186-198 ◽  
Author(s):  
Yu-Sin Jang ◽  
Joungmin Lee ◽  
Alok Malaviya ◽  
Do Young Seung ◽  
Jung Hee Cho ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Metabolic Pathways ◽  
Butanol Production ◽  
Renewable Biomass

Escherichia coli as a platform microbial host for systems metabolic engineering

2021 ◽  
Author(s):  
Dongsoo Yang ◽  
Cindy Pricilia Surya Prabowo ◽  
Hyunmin Eun ◽  
Seon Young Park ◽  
In Jin Cho ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Natural Products ◽  
Metabolic Engineering ◽  
Food Ingredients ◽  
E Coli ◽  
Renewable Biomass ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Systems Metabolic Engineering ◽  
Microbial Host

Abstract Bio-based production of industrially important chemicals and materials from non-edible and renewable biomass has become increasingly important to resolve the urgent worldwide issues including climate change. Also, bio-based production, instead of chemical synthesis, of food ingredients and natural products has gained ever increasing interest for health benefits. Systems metabolic engineering allows more efficient development of microbial cell factories capable of sustainable, green, and human-friendly production of diverse chemicals and materials. Escherichia coli is unarguably the most widely employed host strain for the bio-based production of chemicals and materials. In the present paper, we review the tools and strategies employed for systems metabolic engineering of E. coli. Next, representative examples and strategies for the production of chemicals including biofuels, bulk and specialty chemicals, and natural products are discussed, followed by discussion on materials including polyhydroxyalkanoates (PHAs), proteins, and nanomaterials. Lastly, future perspectives and challenges remaining for systems metabolic engineering of E. coli are discussed.

scholarly journals Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shuobo Shi ◽  
Tong Si ◽  
Zihe Liu ◽  
Hongfang Zhang ◽  
Ee Lui Ang ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Metabolic Engineering ◽  
Butanol Production

Genetically Improved Crops

2014 ◽  
Author(s):  
Martina Newell-McGloughlin
Keyword(s):  
Metabolic Engineering ◽  
Metabolic Pathways ◽  
Nutritional Quality ◽  
New Technologies ◽  
Single Gene ◽  
Basic Knowledge ◽  
Plant Metabolism ◽  
Multiple Components ◽  
Genetically Improved

This article focuses on the technological challenges in developing biotechnology and nutritionally enhanced crops. It discusses how the lack of basic knowledge about plant metabolism has hindered research on improving the nutritional quality of plants. It describes new technologies that seek to counter some of the complex problems in the metabolic engineering of pathways, overcome the limitation of single gene transfers, and facilitate the concomitant transfer of multiple components of metabolic pathways. Sample applications of these technologies are also discussed.

Metabolic engineering ofClostridium acetobutylicumM5 for highly selective butanol production

2009 ◽  
Vol 4 (10) ◽  
pp. 1432-1440 ◽  
Author(s):  
Jin Young Lee ◽  
Yu-Sin Jang ◽  
Joungmin Lee ◽  
Eleftherios Terry Papoutsakis ◽  
Sang Yup Lee
Keyword(s):  
Metabolic Engineering ◽  
Butanol Production

scholarly journals Bio-based 3-hydroxypropionic Acid: A Review

2017 ◽  
Vol 62 (2) ◽  
pp. 156 ◽  
Author(s):  
Aladár Vidra ◽  
Áron Németh
Keyword(s):  
Metabolic Engineering ◽  
Acrylic Acid ◽  
Methyl Acrylate ◽  
Metabolic Pathways ◽  
Commercial Production ◽  
Genetically Engineered ◽  
High Yield ◽  
Biochemical Pathways ◽  
Genetically Engineered Microorganism ◽  
Hydroxypropionic Acid

3-hydroxypropionic acid is a commercially valuable, important platform chemical. It can serve as a precursor for several key compound, such as acrylic acid, 1,3-propanediol, methyl acrylate, acrylamide, ethyl 3-HP, malonic acid, propiolactone and acrylonitrile. Several microorganisms can produce through a range of metabolic pathways. It is indispensable for the commercial production of 3-HP to use cheap and abundant substrates and also to produce in highly efficient processes which could result high yield, titer and productivity. Because  of the fact, that natural microorganism do not perform these conditions, metabolic engineering and genetically engineered microorganism are widely used for research and production as well. Several metabolic pathways are introduced to utilize glucose or glycerol for 3-HP production. In this overview naturally producer microorganisms, synthetic biochemical pathways, results from the recent years and recovery of 3-HP are detailed.

scholarly journals Metabolomic Interactions: An Insight into Health and Disease

2021 ◽  
pp. 61-67
Author(s):  
Maheswara Reddy Mallu ◽  
Shaik Mohammad Anjum ◽  
Sai Sri Samyutha Katravulapalli ◽  
Sri Sai Priya Avuthu ◽  
Koteswara Reddy Gujjula ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Human Body ◽  
Metabolic Pathways ◽  
Biological Processes ◽  
Therapeutic Treatment ◽  
The Past ◽  
Metabolic Functions ◽  
Health And Disease ◽  
Metabolic Reactions ◽  
Insight Into

Over the past decade, metabolic engineering has emerged as an active and distinct discipline characterized by its over-arching emphasis on integration. In practice, metabolic engineering is the directed improvement of cellular properties through the application of modern genetic methods. The concept of metabolic regulations deals with the varied and innumerable metabolic pathways that are present in the human body. A combination of such metabolic reactions paves the way to the proper functioning of different physiological and biological processes. Dealing with the adversities of a disease, engineering of novel metabolic pathways showcases the potential of metabolic engineering and its application in the therapeutic treatment of diseases. A proper and deeper understanding of the metabolic functions in the human body can be known from simulated yeast models. This review gives a brief understanding about the interactions between the molecular set of metabolome and its complexity.

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