scholarly journals Editorial: Protein design and engineering for biocatalysis

2009 ◽  
Vol 4 (4) ◽  
pp. 439-439
Author(s):  
Jiri Damborsky
Keyword(s):  
Protein Design ◽  
Protein Design And Engineering

scholarly journals ProtaBank: A repository for protein design and engineering data

2019 ◽  
Vol 28 (3) ◽  
pp. 672-672
Author(s):  
Connie Y. Wang ◽  
Paul M. Chang ◽  
Marie L. Ary ◽  
Benjamin D. Allen ◽  
Roberto A. Chica ◽  
...  
Keyword(s):  
Protein Design ◽  
Engineering Data ◽  
Protein Design And Engineering

Fluorinated amino acids in protein design and engineering

2002 ◽  
Vol 31 (6) ◽  
pp. 335-341 ◽  
Author(s):  
Nicholas C. Yoder ◽  
Krishna Kumar
Keyword(s):  
Amino Acids ◽  
Protein Design ◽  
Fluorinated Amino Acids ◽  
Protein Design And Engineering

scholarly journals Evolution of fold switching in a metamorphic protein

Science ◽  
2020 ◽  
Vol 371 (6524) ◽  
pp. 86-90
Author(s):  
Acacia F. Dishman ◽  
Robert C. Tyler ◽  
Jamie C. Fox ◽  
Andrew B. Kleist ◽  
Kenneth E. Prehoda ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Protein Design ◽  
Structural Constraints ◽  
Ancestral Reconstruction ◽  
Dimer Interface ◽  
Multiple Structures ◽  
Metamorphic Protein ◽  
Equal Population ◽  
Chemokine Family ◽  
Protein Design And Engineering

Metamorphic proteins switch between different folds, defying the protein folding paradigm. It is unclear how fold switching arises during evolution. With ancestral reconstruction and nuclear magnetic resonance, we studied the evolution of the metamorphic human protein XCL1, which has two distinct folds with different functions, making it an unusual member of the chemokine family, whose members generally adopt one conserved fold. XCL1 evolved from an ancestor with the chemokine fold. Evolution of a dimer interface, changes in structural constraints and molecular strain, and alteration of intramolecular protein contacts drove the evolution of metamorphosis. Then, XCL1 likely evolved to preferentially populate the noncanonical fold before reaching its modern-day near-equal population of folds. These discoveries illuminate how one sequence has evolved to encode multiple structures, revealing principles for protein design and engineering.

Fluoroprolines as Tools for Protein Design and Engineering

2001 ◽  
Vol 40 (5) ◽  
pp. 923-925 ◽  
Author(s):  
Christian Renner ◽  
Stefan Alefelder ◽  
Jae H. Bae ◽  
Nediljko Budisa ◽  
Robert Huber ◽  
...  
Keyword(s):  
Protein Design ◽  
Protein Design And Engineering

scholarly journals ProtaBank: A repository for protein design and engineering data

2018 ◽  
Vol 27 (6) ◽  
pp. 1113-1124 ◽  
Author(s):  
Connie Y. Wang ◽  
Paul M. Chang ◽  
Marie L. Ary ◽  
Benjamin D. Allen ◽  
Roberto A. Chica ◽  
...  
Keyword(s):  
Protein Design ◽  
Engineering Data ◽  
Protein Design And Engineering

scholarly journals A New Tool for Custom Protein Design and Engineering - DH10 Bac-TAG

2016 ◽  
Vol 110 (3) ◽  
pp. 345a
Author(s):  
Christine Koehler ◽  
Paul Sauter ◽  
Mirella Wawryszyn ◽  
Gemma Estrada Girona ◽  
Markus H. Fritz ◽  
...  
Keyword(s):  
Protein Design ◽  
Protein Design And Engineering
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