Structure-function analysis of protein complexes involved in the molecular architecture of juxtaparanodal regions of myelinated fibers

2007 ◽  
Vol 2 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Alexandros Tzimourakas ◽  
Sevasti Giasemi ◽  
Maria Mouratidou ◽  
Domna Karagogeos
Keyword(s):  
Structure Function ◽  
Protein Complexes ◽  
Function Analysis ◽  
Molecular Architecture ◽  
Myelinated Fibers

Neuroligin-2 as a central organizer of inhibitory synapses in health and disease

2020 ◽  
Vol 13 (663) ◽  
pp. eabd8379
Author(s):  
Heba Ali ◽  
Lena Marth ◽  
Dilja Krueger-Burg
Keyword(s):  
Synaptic Transmission ◽  
Synapse Formation ◽  
Current Knowledge ◽  
Protein Complexes ◽  
Inhibitory Synapses ◽  
Molecular Architecture ◽  
Cellular Functions ◽  
Altered Expression ◽  
Health And Disease ◽  
Flow Of Information

Postsynaptic organizational protein complexes play central roles both in orchestrating synapse formation and in defining the functional properties of synaptic transmission that together shape the flow of information through neuronal networks. A key component of these organizational protein complexes is the family of synaptic adhesion proteins called neuroligins. Neuroligins form transsynaptic bridges with presynaptic neurexins to regulate various aspects of excitatory and inhibitory synaptic transmission. Neuroligin-2 (NLGN2) is the only member that acts exclusively at GABAergic inhibitory synapses. Altered expression and mutations in NLGN2 and several of its interacting partners are linked to cognitive and psychiatric disorders, including schizophrenia, autism, and anxiety. Research on NLGN2 has fundamentally shaped our understanding of the molecular architecture of inhibitory synapses. Here, we discuss the current knowledge on the molecular and cellular functions of mammalian NLGN2 and its role in the neuronal circuitry that regulates behavior in rodents and humans.

scholarly journals Structure-function analysis of the C-terminal segment of human interleukin-6.

1993 ◽  
Vol 268 (30) ◽  
pp. 22377-22384 ◽  
Author(s):  
X Li ◽  
F Rock ◽  
P Chong ◽  
S Cockle ◽  
A Keating ◽  
...  
Keyword(s):  
Structure Function ◽  
Interleukin 6 ◽  
Function Analysis ◽  
Terminal Segment
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