Caenorhabditis elegans: A versatile platform for drug discovery

2006 ◽  
Vol 1 (12) ◽  
pp. 1405-1418 ◽  
Author(s):  
Marta Artal-Sanz ◽  
Liesbeth de Jong ◽  
Nektarios Tavernarakis
Keyword(s):  
Drug Discovery ◽  
Caenorhabditis Elegans

Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways

2014 ◽  
Vol 9 (9) ◽  
pp. 1021-1032 ◽  
Author(s):  
Linda P O’Reilly ◽  
Joshua A Benson ◽  
Erin E Cummings ◽  
David H Perlmutter ◽  
Gary A Silverman ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Caenorhabditis Elegans ◽  
Stress Response ◽  
Signaling Pathways ◽  
Insulin Signaling ◽  
Novel Drug

Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics

2020 ◽  
Vol 40 (5) ◽  
pp. 1715-1753
Author(s):  
Daniel Sepúlveda‐Crespo ◽  
Rosa M. Reguera ◽  
Francisco Rojo‐Vázquez ◽  
Rafael Balaña‐Fouce ◽  
María Martínez‐Valladares
Keyword(s):  
Drug Discovery ◽  
Caenorhabditis Elegans

scholarly journals Drug discovery: Insights from the invertebrate Caenorhabditis elegans

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Sebastián Giunti ◽  
Natalia Andersen ◽  
Diego Rayes ◽  
María José De Rosa
Keyword(s):  
Drug Discovery ◽  
Caenorhabditis Elegans

scholarly journals Identification of simple arylfluorosulfates as potent agents against resistant bacteria

2021 ◽  
Vol 118 (28) ◽  
pp. e2103513118
Author(s):  
Jiong Zhang ◽  
Xiangxiang Zhao ◽  
John R. Cappiello ◽  
Yi Yang ◽  
Yunfei Cheng ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Drug Discovery ◽  
Caenorhabditis Elegans ◽  
Synergistic Effect ◽  
Antibacterial Agents ◽  
Bacterial Biofilm ◽  
Resistant Bacteria ◽  
Bacterial Strains ◽  
Structure Activity ◽  
Sulfur Fluoride

Sulfur fluoride exchange (SuFEx), a next generation of click chemistry, opens an avenue for drug discovery. We report here the discovery and structure–activity relationship studies of a series of arylfluorosulfates, synthesized via SuFEx, as antibacterial agents. Arylfluorosulfates 3, 81, and 101 showed potency to overcome multidrug resistance and were not susceptible to the generation of resistance. They exhibited rapid bactericidal potency and selectively killed gram-positive bacterial strains. These compounds also exhibited the ability to disrupt established bacterial biofilm and kill persisters derived from biofilm. Furthermore, arylfluorosulfate 3 had a synergistic effect with streptomycin and gentamicin. In addition, their anti-MRSA potency was evaluated and determined by the Caenorhabditis elegans model.

scholarly journals Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification

2014 ◽  
Vol 22 (5) ◽  
pp. 371-383 ◽  
Author(s):  
Robert A. Kobet ◽  
Xiaoping Pan ◽  
Baohong Zhang ◽  
Stephen C. Pak ◽  
Adam S. Asch ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Caenorhabditis Elegans ◽  
Therapeutic Target ◽  
Target Identification ◽  
Model System ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Anti Cancer
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