Zinc deficiency and taste dysfunction; Contribution of carbonic anhydrase, a zinc-metalloenzyme, to normal taste sensation

BioFactors ◽  
2000 ◽  
Vol 12 (1-4) ◽  
pp. 65-70 ◽  
Author(s):  
Michio Komai ◽  
Tomoko Goto ◽  
Hitoshi Suzuki ◽  
Tomohiko Takeda ◽  
Yuji Furukawa
Keyword(s):  
Carbonic Anhydrase ◽  
Zinc Deficiency ◽  
Taste Sensation ◽  
Taste Dysfunction ◽  
Normal Taste

Zinc Deficiency States and Carbonic Anhydrase Isozyme in Experimental Hemolytic and Bleeding Anemia of Rabbits

Enzyme ◽  
1981 ◽  
Vol 26 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Naoki Ishikawa ◽  
Tadao Shiraishi ◽  
Takahito Kondo ◽  
Naoyuki Taniguchi
Keyword(s):  
Carbonic Anhydrase ◽  
Zinc Deficiency ◽  
Carbonic Anhydrase Isozyme

Carboxylating enzymes and carbonic anhydrase functions were suppressed by zinc deficiency in maize and chickpea plants

2006 ◽  
Vol 28 (5) ◽  
pp. 445-451 ◽  
Author(s):  
Zeinab A. Salama ◽  
Mohamed M. El-Fouly ◽  
Galia Lazova ◽  
Losanka P. Popova
Keyword(s):  
Carbonic Anhydrase ◽  
Zinc Deficiency ◽  
Carboxylating Enzymes

Terbinafine-Associated Taste Disturbance with Normal Taste Threshold Scores

2001 ◽  
Vol 91 (10) ◽  
pp. 540-541 ◽  
Author(s):  
Harvey Lemont ◽  
Marc Sabo
Keyword(s):  
Medical Literature ◽  
Taste Threshold ◽  
Taste Disturbance ◽  
Taste Testing ◽  
Taste Dysfunction ◽  
Taste Thresholds ◽  
Oral Terbinafine ◽  
Normal Taste

The medical literature reveals numerous reports of transient taste disturbance associated with the use of oral terbinafine. A review of these reports, however, fails to confirm taste disturbances by formal taste testing. In this article, a case of long-standing taste dysfunction in a patient who exhibited normal formal taste thresholds is described. (J Am Podiatr Med Assoc 91(10): 540-541, 2001)

scholarly journals Zinc Deficiency, Carbonic Anhydrase, and Photosynthesis in Leaves of Spinach

1973 ◽  
Vol 52 (3) ◽  
pp. 229-232 ◽  
Author(s):  
P. J. Randall ◽  
D. Bouma
Keyword(s):  
Carbonic Anhydrase ◽  
Zinc Deficiency

Reduction in Carbonic Anhydrase Activity in the Tongue Epithelium and Submandibular Gland in Zinc-Deficient Rats

2000 ◽  
Vol 70 (3) ◽  
pp. 110-118 ◽  
Author(s):  
Tomoko Goto ◽  
Michio Komai ◽  
Bruce Bryant ◽  
Yuji Furukawa
Keyword(s):  
Carbonic Anhydrase ◽  
Submandibular Gland ◽  
Positive Reaction ◽  
Zinc Deficiency ◽  
Experimental Period ◽  
Carbonic Anhydrase Activity ◽  
Free Access ◽  
Activity Levels ◽  
Weak Reaction ◽  
Tongue Epithelium

We investigated the effects of zinc deficiency on carbonic anhydrase (CA) activity in the tongue epithelium and submandibular gland in rats. Male 4-week-old SD rats were given free access to a diet containing 2.2 (zinc-deficient), 4.1 (low-zinc), or 33.7 (zinc-sufficient) mg zinc/kg diet for 6 weeks. Rats in the fourth group (receiving 33.7 mg zinc/kg) were pair-fed against the zinc-deficient rats. Biochemical analysis at the end of the experimental period indicated that zinc deficiency significantly reduced CA activity in the tongue epithelium and submandibular gland, and the CA activity levels in these tissues seemed to parallel the dietary zinc levels. By enzyme histochemistry, an intensely positive reaction for CA was observed in the middle and basal regions of the taste buds in the circumvallate papilla in the zinc-sufficient and pair-fed (control) rats. The cells in von Ebner’s glands also showed a strong positive reaction in control rats, although only a weak reaction product was found in zinc-deficient rats. These results suggest that CA activity is affected by the dietary content of zinc, which is considered to be an indispensable factor for the maintenance of normal taste sensation.

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