N-Acetyl-cysteine inhibition of encephalomyelitis Theiler's virus-induced nitric oxide and tumour necrosis factor-α production by murine astrocyte cultures

BioFactors ◽  
1999 ◽  
Vol 10 (2-3) ◽  
pp. 187-193 ◽  
Author(s):  
F. Molina-Holgado ◽  
A. Hernanz ◽  
M. De La Fuente ◽  
C. Guaza
Keyword(s):  
Nitric Oxide ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
Theiler's Virus ◽  
Acetyl Cysteine ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals CD40 and tumour necrosis factor‐α co‐operate to up‐regulate inducuble nitric oxide synthase expression in macrophages

Immunology ◽  
2012 ◽  
Vol 135 (2) ◽  
pp. 140-150 ◽  
Author(s):  
Jose‐Andres C. Portillo ◽  
Luis Muniz Feliciano ◽  
Genevieve Okenka ◽  
Frederick Heinzel ◽  
M. Cecilia Subauste ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Oxide Synthase ◽  
Necrosis Factor

scholarly journals Modulation of macrophage activation by prostaglandins

1996 ◽  
Vol 5 (1) ◽  
pp. 14-17 ◽  
Author(s):  
L. Sautebin ◽  
R. Carnuccio ◽  
F. D'Acquisto ◽  
M. Di Rosa
Keyword(s):  
Nitric Oxide ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Phosphodiesterase Inhibitor ◽  
Inhibitory Effect ◽  
Prostaglandin E ◽  
Tumour Necrosis Factor Α ◽  
Nitric Oxide Release ◽  
Factor Α ◽  
Necrosis Factor

The effect of prostaglandtn E2, iloprost and cAMP on both nitric oxide and tumour necrosis factor-α release in J774 macrophages has been studied. Both prostaglandin E2and iloprost inhibited, in a concentration-dependent fashion, the lipopolysaccharide-induced generation of nitric oxide and tumour necrosis factor-α. The inhibitory effect of these prostanoids seems to be mediated by an increase of the second messenger cAMP since it was mimicked by dibutyryl cAMP and potentiated by the selective type IV phosphodiesterase inhibitor RO-20-1724. Our results suggest that the inhibition of nitric oxide release by prostaglandin E2and iloprost in lipopolysaccharide-activated J774 macrophages may be secondary to the inhibition of tumour necrosis factor-α generation, which in turn is likely to be mediated by cAMP.

scholarly journals Inhibition of Nitric Oxide and Tumour Necrosis Factor-α Production in Peritoneal Macrophages by Aspergillus nidulans Melanin

2013 ◽  
Vol 36 (12) ◽  
pp. 1915-1920 ◽  
Author(s):  
Rita de Cássia Ribeiro Gonçalves ◽  
Rodrigo Rezende Kitagawa ◽  
Maria Stella Gonçalves Raddi ◽  
Iracilda Zeppone Carlos ◽  
Sandra Regina Pombeiro-Sponchiado
Keyword(s):  
Nitric Oxide ◽  
Aspergillus Nidulans ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Peritoneal Macrophages ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor
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