Variation in energy metabolism arising from the effect of the tumor microenvironment on cell biological behaviors of bladder cancer cells and endothelial cells

BioFactors ◽  
2019 ◽  
Vol 46 (1) ◽  
pp. 64-75 ◽  
Author(s):  
Dan Li ◽  
Wei Jiao ◽  
Zhijuan Liang ◽  
Liping Wang ◽  
Yuanbin Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Endothelial Cells ◽  
Energy Metabolism ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Bladder Cancer Cells

799 Exosomal miRNAs: Key regulators of cell-cell communication among bladder cancer cells and tumor microenvironment?

2016 ◽  
Vol 15 (3) ◽  
pp. e799
Author(s):  
S. Baumgart ◽  
J. Heinzelmann ◽  
E. Krause ◽  
M. Stöckle ◽  
M. Stampe Ostenfeld ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cell Communication ◽  
Exosomal Mirnas ◽  
Bladder Cancer Cells ◽  
Cell Cell

scholarly journals MP45-01 EXOSOMAL MIRNAS: KEY REGULATORS OF CELL-CELL COMMUNICATION BETWEEN BLADDER CANCER CELLS AND TUMOR MICROENVIRONMENT

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Sophie Baumgart ◽  
Joana Heinzelmann ◽  
Elmar Krause ◽  
Marie Stampe Ostenfeld ◽  
Arndt Hartmann ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cell Communication ◽  
Exosomal Mirnas ◽  
Bladder Cancer Cells ◽  
Cell Cell

scholarly journals Bladder cancer-derived interleukin-1 converts the vascular endothelium into a pro-inflammatory and pro-coagulatory surface

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
A. John ◽  
C. Günes ◽  
C. Bolenz ◽  
S. Vidal-y-Sy ◽  
A. T. Bauer ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cancer Cells ◽  
Vascular Endothelium ◽  
Cell Activation ◽  
Human Bladder Cancer ◽  
Endothelial Cell Activation ◽  
Human Bladder ◽  
Bladder Cancer Cells

Abstract Background Bladder cancer cells orchestrate tumour progression by pro-inflammatory cytokines. Cytokines modulate the local tumour microenvironment and increase the susceptibility of tumour distant tissues for metastasis. Here, we investigated the impact of human bladder cancer cell derived factors on the ability to modulate and activate human vascular endothelial cells. Methods The pro-inflammatory and pro-coagulatory potential of four different bladder cancer cell lines was accessed by qRT-PCR arrays and ELISA. Modulation and activation of endothelial cells was studied in microfluidic devices. Clinical relevance of our findings was confirmed by immune histology in tissue samples of bladder cancer patients and public transcriptome data. Results The unbalanced ratio between interleukin (IL)-1 and IL-1 receptor antagonist (IL-1ra) in the secretome of bladder cancer cells converted the quiescent vascular endothelium into a pro-adhesive, pro-inflammatory, and pro-coagulatory surface. Microfluidic experiments showed that tumour cell induced endothelial cell activation promoted leukocyte recruitment and platelet adhesion. Human bladder cancer tissue analysis confirmed that loss of IL-1ra and elevated IL-1 expression was associated with enhanced cancer progression. Conclusions Our data indicate that IL-1 and IL-1ra were dysregulated in bladder cancer and could facilitate tumour dissemination through endothelial cell activation. Targeting the IL-1/IL-1ra axis might attenuate tumour-mediated inflammation and metastasis formation.

758: Inflammatory and Anti-Inflammatory Regulators alter Levels of an Inhibitor of Apoptosis (IAP), Survivin, in T-24 Bladder Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 254-254
Author(s):  
Justin J. Cohen ◽  
Bayan T. Takizawa ◽  
Hristos Z. Kaimkliotis ◽  
David J. Rosenberg ◽  
Marcia A. Wheeler ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Inhibitor Of Apoptosis ◽  
Bladder Cancer Cells ◽  
Anti Inflammatory

792: Role of Oxidative Stress in Tumorigenic Potential of Bladder Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 214-215 ◽  
Author(s):  
Daniel Cho ◽  
Xiao Fang Ha ◽  
J. Andre Melendez ◽  
Louis J. Giorgi ◽  
Badar M. Mian
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Tumorigenic Potential ◽  
Bladder Cancer Cells

627: Multitarget Gene Inhibition by Synthetic Nucleic Acids in Bladder Cancer Cells

2006 ◽  
Vol 175 (4S) ◽  
pp. 202-202 ◽  
Author(s):  
Yvonne Burmeister ◽  
Kai Kraemer ◽  
Susanne Fuessel ◽  
Matthias Kotzsch ◽  
Axel Meye ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Nucleic Acids ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
Gene Inhibition

723: Chemokine Receptor CXCR4 Mediates Migration and Invasion of Bladder Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 192-192 ◽  
Author(s):  
Margitta Retz ◽  
Sukhvinder S. Sidhu ◽  
Gregory M. Dolganov ◽  
Jan Lehmann ◽  
Peter R. Carroll ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Chemokine Receptor ◽  
Migration And Invasion ◽  
Chemokine Receptor Cxcr4 ◽  
Bladder Cancer Cells
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