Determination of cefixime in pure form, in pharmaceutical products and biological samples through fluorescence quenching of eosin Y

Luminescence ◽  
2020 ◽  
Author(s):  
Muhammad N. Khan ◽  
Irum ◽  
Muhammad Mursaleen
Keyword(s):  
Fluorescence Quenching ◽  
Biological Samples ◽  
Pharmaceutical Products ◽  
Pure Form ◽  
Eosin Y

scholarly journals Development and validation of a new spectrofluorimetric method for the determination of some beta-blockers through fluorescence quenching of eosin Y. Application to content uniformity test

2016 ◽  
Vol 14 (1) ◽  
pp. 258-266 ◽  
Author(s):  
Sayed M Derayea ◽  
Mahmoud A Omar ◽  
Mohamed Aboel-Kasem Abdel-Lateef ◽  
Ahmed I. Hassan
Keyword(s):  
Fluorescence Quenching ◽  
Beta Blockers ◽  
Dosage Forms ◽  
Ion Pair ◽  
Content Uniformity ◽  
Eosin Y ◽  
Pharmaceutical Dosage Forms ◽  
Quenching Effect ◽  
Spectrofluorimetric Method

AbstractA simple, rapid, sensitive and economic spectrofluorimetric method has been developed and validated for determination of some β-adrenergic blocking agents namely; betaxolol hydrochloride (BTX), carvedilol (CAR), labetalol hydrochloride (LBT), nebivolol hydrochloride (NEB) and propranolol hydrochloride (PRO). The method is based on the quenching effect of the cited drugs on the fluorescence intensity of eosin Y at pH 3.4 (acetate buffer). The fluorescence quenching is due to the formation of an ion-pair complex and was measured without extraction at 545 nm (λex. 301.5 nm). The factors affecting the formation of the ion-pair complex were carefully studied and optimized. Under the optimal conditions, the linear ranges for the relationship between the fluorescence quenching value and the concentration of the investigated drugs were 100-2500, 150-2500 and 50-2250 ng mL-1 for (BTX, CAR), (LBT, NEB) and (PRO) respectively. The method was validated according to ICH guidelines and was applied for determination of the cited drugs in pharmaceutical dosage forms with excellent recoveries. In addition, content uniformity testing of some commercial dosage forms was checked by the proposed method.

Spectrofluorimetric approach for determination of citicoline in the presence of co-formulated piracetam through fluorescence quenching of eosin Y

2020 ◽  
Vol 236 ◽  
pp. 118337 ◽  
Author(s):  
Mahmoud A. Omar ◽  
Amal B. Ahmed ◽  
Nada S. Abdelwahab ◽  
Maha M. Abdelrahman ◽  
Sayed M. Derayea
Keyword(s):  
Fluorescence Quenching ◽  
Eosin Y

scholarly journals Instrumental Analysis of Chlordiazepoxide in Different Matrices

2021 ◽  
pp. 1-10
Author(s):  
Lobna M. Abdel-Aziz ◽  
Ahmed A. Soror ◽  
Ahmed A. Hassan ◽  
Ahmed S. Ali ◽  
Ahmed A. Hafez ◽  
...  
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Analytical Methods ◽  
Degradation Products ◽  
Electrochemical Techniques ◽  
Pharmacological Action ◽  
Pure Form ◽  
Instrumental Analysis ◽  
The World

Chlordiazepoxide is considered one of most important sedative and hypnotic benzodiazepines drugs which is currently used all over the world with the increased rate of anxiety drugs. In this literature review, we will introduce the pharmacological action of this drug in addition to most of up-to-date reported methods that have been developed for determination of chlordiazepoxide in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples. Most of the reported analytical methods will focus on spectroscopic, chromatographic and electrochemical techniques.

scholarly journals Analytical Methods for Determination of Salbutamol, Ambroxol and Fexofenadine

2020 ◽  
Vol 1 (1) ◽  
pp. 01-11
Author(s):  
Mahmoud Sebaiy
Keyword(s):  
Biological Samples ◽  
Analytical Methods ◽  
Degradation Products ◽  
Review Article ◽  
Pure Form

In this review article, we will introduce all reported methods that have been developed for determination of certain anti-tussive and anti-histaminic drugs such as salbutamol, ambroxol and fexofenadine in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of asthma and related diseases.

Micellar-Enhanced Spectrofluorimetric Method for Quantification of Diclofenac Potassium in Pure Form, in Pharmaceutical Preparations and Human Plasma

2021 ◽  
Vol 58 (6) ◽  
pp. 427-434
Author(s):  
Muhammad Naeem Khan ◽  
Irum ◽  
Saba Gul ◽  
Muslima ◽  
Muhammad Mursaleen
Keyword(s):  
Human Plasma ◽  
Limit Of Detection ◽  
Sodium Dodecyl ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Products ◽  
Pure Form ◽  
Fluorescence Signal ◽  
Spectrofluorimetric Method ◽  
Relative Standard

Abstract A rapid, simple and economical spectrofluorimetric method for the determination of diclofenac potassium in pure form, in pharmaceutical preparations and in human plasma has been developed. The method is based on the enhancement of the fluorescence signal of diclofenac potassium by the addition of sodium dodecyl sulphate in McIvaine buffer with a pH of 5. Different experimental conditions such as buffer type, pH, type and concentration of surfactants were investigated. The fluorescence intensity of the solution was recorded at 361 nm after excitation at 243 nm. The method shows linearity in the concentration range of 0.2 μg mL–1–10 μg mL–1 with a good correlation coefficient of 0.997. The relative standard deviation value was 3.62 (n = 7). The limit of detection and limit of quantification were calculated to be 2.84 × 10–3 μg mL–1 and 9.47 × 10–3 μg mL-1, respectively. The effect of excipients and co-administrated drugs was investigated and no interference was observed. The method was successfully applied for the determination of diclofenac potassium in pure form, in pharmaceutical products and in human plasma. The percentage recoveries obtained ranged from 100.25% to 102.16% for pure form and 97.50% to 102.00% for pharmaceutical products and from 98.50% to 101.67% for human plasma.

Fluorescence Quenching Reaction of Polyvinylpyrrolidone-Eosin Y System for the Determination of Polyvinylpyrrolidone

2010 ◽  
Vol 20 (3) ◽  
pp. 733-738 ◽  
Author(s):  
Lihong Yu ◽  
Zhongfang Liu ◽  
Xiaoli Hu ◽  
Ling Kong ◽  
Shaopu Liu
Keyword(s):  
Fluorescence Quenching ◽  
Eosin Y

scholarly journals Review article on Analytical Techniques of Lamivudine Determination in Different Matrices

2021 ◽  
Vol 2 (3) ◽  
pp. 37-46
Author(s):  
Roshdy E. Saraya ◽  
Magda Elhenawee ◽  
Hanaa Saleh ◽  
Mahmoud M. Sebaiy Sebaiy
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Degradation Products ◽  
Analytical Techniques ◽  
Review Article ◽  
Pure Form

In this literature review, we will introduce most of up-to-date reported methods that have been developed for determination of lamivudine in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples.

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