Mouse period1 gene expression recording from olfactory bulb under free moving conditions with a portable optic fibre device

Luminescence ◽  
2020 ◽  
Vol 35 (8) ◽  
pp. 1248-1253
Author(s):  
Ryoga Ito ◽  
Kazuko Hamada ◽  
Shigeru Kasahara ◽  
Yoshihiro Kikuchi ◽  
Kanako Nakajima ◽  
...  
Keyword(s):  
Gene Expression ◽  
Olfactory Bulb ◽  
Optic Fibre

scholarly journals Diet-Induced Obesity Disrupts Trace Element Homeostasis and Gene Expression in the Olfactory Bulb

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3909
Author(s):  
Melissa S. Totten ◽  
Derek M. Pierce ◽  
Keith M. Erikson
Keyword(s):  
Gene Expression ◽  
Olfactory Bulb ◽  
Trace Element ◽  
Alpha Synuclein ◽  
Divalent Metal Transporter 1 ◽  
Diet Induced Obesity ◽  
Mrna Gene ◽  
The Impact ◽  
Mrna Gene Expression ◽  
Obese Male

The aim of this study was to determine the impact of diet-induced obesity (DIO) on trace element homeostasis and gene expression in the olfactory bulb and to identify potential interaction effects between diet, sex, and strain. Our study is based on evidence that obesity and olfactory bulb impairments are linked to neurodegenerative processes. Briefly, C57BL/6J (B6J) and DBA/2J (D2J) male and female mice were fed either a low-fat diet or a high-fat diet for 16 weeks. Brain tissue was then evaluated for iron, manganese, copper, and zinc concentrations and mRNA gene expression. There was a statistically significant diet-by-sex interaction for iron and a three-way interaction between diet, sex, and strain for zinc in the olfactory bulb. Obese male B6J mice had a striking 75% increase in iron and a 50% increase in manganese compared with the control. There was an increase in zinc due to DIO in B6J males and D2J females, but a decrease in zinc in B6J females and D2J males. Obese male D2J mice had significantly upregulated mRNA gene expression for divalent metal transporter 1, alpha-synuclein, amyloid precursor protein, dopamine receptor D2, and tyrosine hydroxylase. B6J females with DIO had significantly upregulated brain-derived neurotrophic factor expression. Our results demonstrate that DIO has the potential to disrupt trace element homeostasis and mRNA gene expression in the olfactory bulb, with effects that depend on sex and genetics. We found that DIO led to alterations in iron and manganese predominantly in male B6J mice, and gene expression dysregulation mainly in male D2J mice. These results have important implications for health outcomes related to obesity with possible connections to neurodegenerative disease.

scholarly journals Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior

2010 ◽  
pp. no-no
Author(s):  
Xiangru Xu ◽  
Mohamed R. Mughal ◽  
F. Scott Hall ◽  
Maria T. G. Perona ◽  
Paul J. Pistell ◽  
...  
Keyword(s):  
Gene Expression ◽  
Olfactory Bulb ◽  
Dietary Restriction ◽  
Cellular Plasticity ◽  
And Behavior

Differential gene expression profiles of the olfactory bulb after nasal obstruction in neonatal rats

2008 ◽  
Vol 138 (5) ◽  
pp. 648-654 ◽  
Author(s):  
Gan-Undram Semjidsuren ◽  
Gi Jung Im ◽  
Sang Hag Lee ◽  
Se Jin Park ◽  
Ho Yeon Hwang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Olfactory Bulb ◽  
Differential Gene Expression ◽  
Nasal Obstruction ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Neonatal Rats ◽  
Differential Gene

scholarly journals Spatial patterns of gene expression in the olfactory bulb

2004 ◽  
Vol 101 (34) ◽  
pp. 12718-12723 ◽  
Author(s):  
D. M. Lin ◽  
Y. H. Yang ◽  
J. A. Scolnick ◽  
L. J. Brunet ◽  
H. Marsh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Olfactory Bulb ◽  
Spatial Patterns

scholarly journals Effects of Rosemary Oil (Rosmarinus Officinalis) Supplementation on the Fate of the Transplanted Human Olfactory Bulb Neural Stem Cells Against Ibotenic Acid-Induced Neurotoxicity (Alzheimer Model) in Rat

2021 ◽  
Author(s):  
Shaymaa Rezk ◽  
Samah Lashen ◽  
Mohamed EL-Adl ◽  
Gehad E. Elshopakey ◽  
Mona M. Elghareeb ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Olfactory Bulb ◽  
Cell Transplantation ◽  
Memory Function ◽  
Treated Group ◽  
Learning Ability ◽  
Total Leukocyte Count ◽  
Neuronal Stem Cells ◽  
Rosemary Oil

Abstract Rosemary oil (ROO) is known to have multiple pharmacological effects: it is an antioxidant, an anti-inflammatory, and cytoprotective. In the present study, we examined the effects of ROO on Human olfactory bulb neuronal stem cells (hOBNSCs) after their transplantation into rats, with the ibotenic (IBO) acid-induced cognitive deficit model. After 7 weeks, cognitive functions were assessed using the Morris water maze (MWM). After two months blood and the hippocampus were collected for biochemical, gene expression, and histomorphometric analyses. Learning ability and memory function were significantly enhanced after hOBNSCs transplantation and were nearly returned to normal in the treated group. The IBO acid injection was associated with a significant decline of total leukocyte count (TLC) and a significant increase in total and toxic neutrophils. As well, the level of IL-1β, TNF-α CRP in serum and levels of MDA and NO in hippocampus tissue were significantly elevated, while antioxidant markers (CAT, GSH, and SOD) were reduced in treated tissue compared to controls. The administration of ROO before or with cell transplantation attenuated all these parameters. In particular, the level of NO nearly returned to normal when rosemary was administrated before cell transplantation. Gene expression analysis revealed the potential protective effect of ROO and hOBNSCs via down-expression of R-βAmyl and R- CAS 3 and R-GFAP genes.

Regulation of c-Fos gene expression in the rat olfactory bulb during olfactory learning

2007 ◽  
Vol 37 (7) ◽  
pp. 697-704 ◽  
Author(s):  
N. A. Solov’eva ◽  
L. V. Lagutina ◽  
L. V. Antonova ◽  
K. V. Anokhin
Keyword(s):  
Gene Expression ◽  
Olfactory Bulb ◽  
Olfactory Learning

scholarly journals Gene Expression Profile of Adult Human Olfactory Bulb and Embryonic Neural Stem Cell Suggests Distinct Signaling Pathways and Epigenetic Control

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e33542 ◽  
Author(s):  
Hany E. S. Marei ◽  
Abd-Elmaksoud Ahmed ◽  
Fabrizio Michetti ◽  
Mario Pescatori ◽  
Roberto Pallini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Olfactory Bulb ◽  
Signaling Pathways ◽  
Gene Expression Profile ◽  
Neural Stem Cell ◽  
Expression Profile ◽  
Epigenetic Control ◽  
Adult Human ◽  
Embryonic Neural Stem Cell
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