Steady-state and synchronous spectrofluorimetric methods for simultaneous determination of aliskiren hemifumarate and amlodipine besylate in dosage forms

Luminescence ◽  
2014 ◽  
Vol 29 (7) ◽  
pp. 878-883 ◽  
Author(s):  
Walid M. Ebeid ◽  
Ehab F. Elkady ◽  
Asmaa A. El-Zaher ◽  
Ramzia I. El-Bagary ◽  
Gabor Patonay
Keyword(s):  
Steady State ◽  
Simultaneous Determination ◽  
Dosage Forms ◽  
Amlodipine Besylate

scholarly journals A validated stability-indicating HPLC method for simultaneous determination of Silymarin and Curcumin in various dosage forms

2017 ◽  
Vol 10 ◽  
pp. S1711-S1725 ◽  
Author(s):  
Mohamed A. Korany ◽  
Rim S. Haggag ◽  
Marwa A.A. Ragab ◽  
Osama A. Elmallah
Keyword(s):  
Simultaneous Determination ◽  
Dosage Forms ◽  
Hplc Method ◽  
Stability Indicating

DAD Based Stability Indicating RP-UPLC Method for Simultaneous Determination of Olmesartan Medoxomil and Amlodipine Besylate

2019 ◽  
Vol 52 (11) ◽  
pp. 959-964 ◽  
Author(s):  
Jayshri R. Kerai ◽  
Amitkumar J. Vyas ◽  
Bhupatsinh Vihol ◽  
Parth Patel ◽  
Ashok Patel
Keyword(s):  
Simultaneous Determination ◽  
Olmesartan Medoxomil ◽  
Amlodipine Besylate ◽  
Stability Indicating

scholarly journals Stability-Indicating Validated HPLC Method for Simultaneous Determination of Oral Antidiabetic Drugs from Thiazolidinedione and Sulfonylurea Groups in Combined Dosage Forms

2010 ◽  
Vol 93 (4) ◽  
pp. 1086-1092 ◽  
Author(s):  
Anna Gumieniczek ◽  
Anna Berecka ◽  
ukasz Komsta
Keyword(s):  
Simultaneous Determination ◽  
Mobile Phase ◽  
Uv Light ◽  
Degradation Products ◽  
Dosage Forms ◽  
Hplc Method ◽  
Base Temperature ◽  
Stability Indicating ◽  
Acid And Base

Abstract For type 2 diabetes treatment, combinations of drugs from the thiazolidinedione and sulfonylurea groups are now available in the same tablet or capsule. Therefore, a stability-indicating and validated HPLC method was developed for simultaneous determination of pioglitazone, rosiglitazone, and glipizide in combined dosage forms. The examined drugs were subjected to different conditions such as acid and base, temperature, and UV light, and degradation of pioglitazone and glipizide was observed under thermal and acidic stress. However, selectivity of the presented method for pioglitazone, rosiglitazone, and glipizide assay against their degradation products was confirmed. It was also demonstrated to be robust, resisting small deliberate changes in pH of the buffer, flow rate, and percentage of acetonitrile in the mobile phase. The presented method utilizes a LiChrospher RP18 column (125 4.0 mm), acetonitrile in phosphate buffer at pH 4.3 (40 + 60, v/v) as the mobile phase, and UV detection at 225 nm for pioglitazone/glipizide or 245 nm for rosiglitazone/glipizide. The method was validated with respect to linearity, precision, and accuracy. Finally, the elaborated procedure was applied for the QC of pioglitazone/glipizide and rosiglitazone/glipizide mixtures.

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