Optimal sample size allocation and go/no-go decision rules for phase II/III programs where several phase III trials are performed

2018 ◽  
Vol 61 (2) ◽  
pp. 357-378 ◽  
Author(s):  
Stella Preussler ◽  
Meinhard Kieser ◽  
Marietta Kirchner
Keyword(s):  
Sample Size ◽  
Phase Ii ◽  
Decision Rules ◽  
Phase Iii ◽  
Optimal Sample Size ◽  
Optimal Sample ◽  
Sample Size Allocation ◽  
Phase Iii Trials

Estimation of optimum sample size allocation: An illustration with body mass index for evaluating the effect of a dietetic supplement

2019 ◽  
Vol 12 (08) ◽  
pp. 1950086
Author(s):  
Carlos N. Bouza-Herrera ◽  
Sira M. Allende-Alonso ◽  
Gajendra K. Vishwakarma ◽  
Neha Singh
Keyword(s):  
Body Mass Index ◽  
Numerical Methods ◽  
Sample Size ◽  
Body Mass ◽  
Optimal Allocation ◽  
Computing Time ◽  
Optimal Sample Size ◽  
Optimum Sample Size ◽  
Optimal Sample ◽  
Sample Size Allocation

In many medical researches, it is needed to determine the optimal sample size allocation in a heterogeneous population. This paper proposes the algorithm for optimal sample size allocation. We consider the optimal allocation problem as an optimization problem and the solution is obtained by using Bisection, Secant, Regula–Falsi and other numerical methods. The performance of the algorithm for different numerical methods are analyzed and evaluated in terms of computing time, number of iterations and gain in accuracy using stratification. The efficacy of algorithm is evaluated for the response in terms of body mass index (BMI) to the dietetic supplement with diabetes mellitus, HIV/AIDS and cancer post-operatory recovery patients.

scholarly journals Multiple sensitive estimation and optimal sample size allocation in the item sum technique

2017 ◽  
Vol 60 (1) ◽  
pp. 155-173 ◽  
Author(s):  
Pier Francesco Perri ◽  
María del Mar Rueda García ◽  
Beatriz Cobo Rodríguez
Keyword(s):  
Sample Size ◽  
Optimal Sample Size ◽  
Optimal Sample ◽  
Sample Size Allocation
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