AMP-activated protein kinase - An archetypal protein kinase cascade?

BioEssays ◽  
1992 ◽  
Vol 14 (10) ◽  
pp. 699-704 ◽  
Author(s):  
D. Grahame Hardie ◽  
Robert W. Mackintosh
Keyword(s):  
Protein Kinase ◽  
Kinase Cascade ◽  
Amp Activated Protein Kinase ◽  
Protein Kinase Cascade

AMP-activated protein kinase: new regulation, new roles?

2012 ◽  
Vol 445 (1) ◽  
pp. 11-27 ◽  
Author(s):  
David Carling ◽  
Claire Thornton ◽  
Angela Woods ◽  
Matthew J. Sanders
Keyword(s):  
Protein Kinase ◽  
Living Cells ◽  
Cellular Functions ◽  
Disease States ◽  
Kinase Cascade ◽  
Amp Activated Protein Kinase ◽  
Obesity And Cancer ◽  
Hydrolysis Of ◽  
Protein Kinase Cascade

The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A prerequisite of living cells is that the concentration of ATP needs to be maintained at sufficiently high levels to sustain essential cellular functions. In eukaryotic cells, the AMPK (AMP-activated protein kinase) cascade is one of the systems that have evolved to ensure that energy homoeostasis is maintained. AMPK is activated in response to a fall in ATP, and recent studies have suggested that ADP plays an important role in regulating AMPK. Once activated, AMPK phosphorylates a broad range of downstream targets, resulting in the overall effect of increasing ATP-producing pathways whilst decreasing ATP-utilizing pathways. Disturbances in energy homoeostasis underlie a number of disease states in humans, e.g. Type 2 diabetes, obesity and cancer. Reflecting its key role in energy metabolism, AMPK has emerged as a potential therapeutic target. In the present review we examine the recent progress aimed at understanding the regulation of AMPK and discuss some of the latest developments that have emerged in key areas of human physiology where AMPK is thought to play an important role.

scholarly journals LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 ◽  
Vol 13 (22) ◽  
pp. 2004-2008 ◽  
Author(s):  
Angela Woods ◽  
Stephen R. Johnstone ◽  
Kristina Dickerson ◽  
Fiona C. Leiper ◽  
Lee G.D. Fryer ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Upstream Kinase ◽  
Kinase Cascade ◽  
Amp Activated Protein Kinase ◽  
Protein Kinase Cascade
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