What The Papers Say: Retinoic acid: The morphogen of the main body axis?

BioEssays ◽  
1990 ◽  
Vol 12 (9) ◽  
pp. 437-439 ◽  
Author(s):  
Jeremy B. A. Green
Keyword(s):  
Retinoic Acid ◽  
Body Axis ◽  
Main Body

scholarly journals Retinoic acid controls body axis extension by directly repressing Fgf8 transcription

Development ◽  
2014 ◽  
Vol 141 (15) ◽  
pp. 2972-2977 ◽  
Author(s):  
S. Kumar ◽  
G. Duester
Keyword(s):  
Retinoic Acid ◽  
Body Axis ◽  
Axis Extension

scholarly journals Uncoupling of retinoic acid signaling from tailbud development before termination of body axis extension

genesis ◽  
2011 ◽  
Vol 49 (10) ◽  
pp. 776-783 ◽  
Author(s):  
Thomas J. Cunningham ◽  
Xianling Zhao ◽  
Gregg Duester
Keyword(s):  
Retinoic Acid ◽  
Body Axis ◽  
Retinoic Acid Signaling ◽  
Axis Extension

scholarly journals β-catenin dependent axial patterning in Cnidaria and Bilateria uses similar regulatory logic

2020 ◽  
Author(s):  
Tatiana Bagaeva ◽  
Andrew J. Aman ◽  
Thomas Graf ◽  
Isabell Niedermoser ◽  
Bob Zimmermann ◽  
...  
Keyword(s):  
Sister Group ◽  
Sea Anemone ◽  
Body Axis ◽  
Evolutionary Origin ◽  
Main Body ◽  
Anatomical Structures ◽  
Axial Patterning ◽  
Common Evolutionary Origin ◽  
Animal Phyla

AbstractIn animals, body axis patterning is based on the concentration-dependent interpretation of graded morphogen signals, which enables correct positioning of the anatomical structures. The most ancient axis patterning system acting across animal phyla relies on β-catenin signaling, which directs gastrulation, and patterns the main body axis. However, within Bilateria, the patterning logic varies significantly between protostomes and deuterostomes. To deduce the ancestral principles of β-catenin dependent axial patterning, we investigated the oral-aboral axis patterning in the sea anemone Nematostella - a member of the bilaterian sister group Cnidaria. Here we elucidate the regulatory logic by which more orally expressed β-catenin targets repress more aborally expressed β- catenin targets, and progressively restrict the initially global, maternally provided aboral identity. Similar regulatory logic of β-catenin-dependent patterning in Nematostella and deuterostomes suggests a common evolutionary origin of these processes.

scholarly journals Mouse but not zebrafish requires retinoic acid for control of neuromesodermal progenitors and body axis extension

2018 ◽  
Vol 441 (1) ◽  
pp. 127-131 ◽  
Author(s):  
Marie Berenguer ◽  
Joseph J. Lancman ◽  
Thomas J. Cunningham ◽  
P. Duc Si Dong ◽  
Gregg Duester
Keyword(s):  
Retinoic Acid ◽  
Body Axis ◽  
Axis Extension

scholarly journals Developmental Principles: Fact or Fiction

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
A. J. Durston
Keyword(s):  
Periodic Table ◽  
Chemical Elements ◽  
Body Axis ◽  
Main Body ◽  
Developmental Genetic ◽  
Developmental Mechanisms ◽  
Genetic Mechanisms ◽  
Developmental Principles

While still at school, most of us are deeply impressed by the underlying principles that so beautifully explain why the chemical elements are ordered as they are in the periodic table, and may wonder, with the theoretician Brian Goodwin, “whether there might be equally powerful principles that account for the awe-inspiring diversity of body forms in the living realm”. We have considered the arguments for developmental principles, conclude that they do exist and have specifically identified features that may generate principles associated with Hox patterning of the main body axis in bilaterian metazoa in general and in the vertebrates in particular. We wonder whether this exercise serves any purpose. The features we discuss were already known to us as parts of developmental mechanisms and defining developmental principles (how, and at which level?) adds no insight. We also see little profit in the proposal by Goodwin that there are principles outside the emerging genetic mechanisms that need to be taken into account. The emerging developmental genetic hierarchies already reveal a wealth of interesting phenomena, whatever we choose to call them.

scholarly journals Hoxc6 loss of function truncates the main body axis in Xenopus

Cell Cycle ◽  
2017 ◽  
Vol 16 (11) ◽  
pp. 1136-1138 ◽  
Author(s):  
Kongju Zhu ◽  
Herman P. Spaink ◽  
Antony J. Durston
Keyword(s):  
Body Axis ◽  
Main Body ◽  
Loss Of Function

scholarly journals A Tribute to Lewis Wolpert on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis

2019 ◽  
Author(s):  
Antony Durston
Keyword(s):  
Developmental Biology ◽  
Spatial Pattern ◽  
Limb Development ◽  
50Th Anniversary ◽  
Positional Information ◽  
Body Axis ◽  
Main Body ◽  
Vertebrate Development ◽  
Timing Model ◽  
Anterior Posterior

This article is a tribute to Lewis Wolpert on the occasion of the recent 50th anniversary of the publication of his article ‘Positional Information and the Spatial Pattern of Differentiation’. This tribute relates to another of his ideas: his early ‘Progress Zone’ timing model for limb development. Recent evidence is reviewed that a mechanism sharing features with this model patterns the main body axis in early vertebrate development. This tribute celebrates the golden era of Developmental Biology.

scholarly journals Discovery of genes required for body axis and limb formation by global identification of retinoic acid regulated epigenetic marks

2019 ◽  
Author(s):  
Marie Berenguer ◽  
Karolin F. Meyer ◽  
Jun Yin ◽  
Gregg Duester
Keyword(s):  
Retinoic Acid ◽  
Target Genes ◽  
Gene Activation ◽  
Body Axis ◽  
Rna Seq ◽  
Altered Expression ◽  
Epigenetic Marks ◽  
Number Of Genes ◽  
Global Identification ◽  
Specific Tissue

AbstractIdentification of target genes that mediate required functions downstream of transcription factors is hampered by the large number of genes whose expression changes when the factor is removed from a specific tissue and the numerous binding sites for the factor in the genome. Retinoic acid (RA) regulates transcription via RA receptors bound to RA response elements (RAREs) of which there are thousands in vertebrate genomes. Here, we combined ChIP-seq for epigenetic marks and RNA-seq on trunk tissue from wild-type and Aldh1a2-/-embryos lacking RA synthesis that exhibit body axis and forelimb defects. We identified a relatively small number of genes with altered expression when RA is missing that also have nearby RA-regulated deposition of H3K27ac (gene activation mark) or H3K27me3 (gene repression mark) associated with conserved RAREs, suggesting they have important downstream functions. RA-regulated epigenetic marks were identified near RA target genes already known to be required for body axis and limb formation, thus validating our approach, plus many other candidate RA target genes were found. Nr2f1, Nr2f2, Meis1, and Meis2 gene family members were identified by our approach, and double knockouts of each family demonstrated previously unknown requirements for body axis and/or limb formation. These findings demonstrate that our method for identifying RA-regulated epigenetic marks can be used to discover genes important for development.

scholarly journals Two new species, including one representing a new genus, of the West African millipede family Campodesmidae (Diplopoda: Polydesmida)

2015 ◽  
Author(s):  
Didier VandenSpiegel ◽  
Sergei I. Golovatch ◽  
Armand R. Nzoko Fiemapong
Keyword(s):  
New Species ◽  
Ivory Coast ◽  
New Genus ◽  
Lateral Lobe ◽  
West African ◽  
Body Axis ◽  
Main Body ◽  
The West ◽  
Two New Species

A new genus, Campodesmoides gen. nov., is described to only encompass C. corniger sp. nov., from Cameroon. This genus and species is distinguished from the few known species of the small western African family Campodesmidae, all currently in Campodesmus, by the much longer antennae and legs, the normal pore formula with ozopores borne on porosteles, and the suberect and distally twisted gonopod, coupled with peculiar horns on a few anterior postcollum segments. A new Campodesmus is also described, C. alobatus sp. nov., from Ivory Coast, which differs from congeners primarily in the lack of a dorsal/lateral lobe on the otherwise usual and strongly subcircular gonopod telopodite, albeit the latter is not directed mesad, but held subparallel to the main body axis.

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