DNA polymerase delta: A second eukaryotic DNA replicase

BioEssays ◽  
1990 ◽  
Vol 12 (5) ◽  
pp. 231-236 ◽  
Author(s):  
Kathleen M. Downey ◽  
Cheng-Keat Tan ◽  
Antero G. So
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Delta ◽  
Eukaryotic Dna ◽  
Dna Replicase

scholarly journals A Hypothesis for DNA Viruses as the Origin of Eukaryotic Replication Proteins

2000 ◽  
Vol 74 (15) ◽  
pp. 7079-7084 ◽  
Author(s):  
Luis P. Villarreal ◽  
Victor R. DeFilippis
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerases ◽  
Reverse Direction ◽  
Amino Terminus ◽  
Replication Proteins ◽  
Dna Polymerase Delta ◽  
Dna Virus ◽  
Significant Similarity ◽  
Dna Viruses ◽  
Eukaryotic Dna

ABSTRACT The eukaryotic replicative DNA polymerases are similar to those of large DNA viruses of eukaryotic and bacterial T4 phages but not to those of eubacteria. We develop and examine the hypothesis that DNA virus replication proteins gave rise to those of eukaryotes during evolution. We chose the DNA polymerase from phycodnavirus (which infects microalgae) as the basis of this analysis, as it represents a virus of a primitive eukaryote. We show that it has significant similarity with replicative DNA polymerases of eukaryotes and certain of their large DNA viruses. Sequence alignment confirms this similarity and establishes the presence of highly conserved domains in the polymerase amino terminus. Subsequent reconstruction of a phylogenetic tree indicates that these algal viral DNA polymerases are near the root of the clade containing all eukaryotic DNA polymerase delta members but that this clade does not contain the polymerases of other DNA viruses. We consider arguments for the polarity of this relationship and present the hypothesis that the replication genes of DNA viruses gave rise to those of eukaryotes and not the reverse direction.

scholarly journals Regulation of human DNA polymerase delta during the cell cycle.

1994 ◽  
Vol 269 (39) ◽  
pp. 24027-24033
Author(s):  
X.R. Zeng ◽  
H. Hao ◽  
Y. Jiang ◽  
M.Y. Lee
Keyword(s):  
Cell Cycle ◽  
Dna Polymerase ◽  
Dna Polymerase Delta ◽  
Human Dna

Properties of two forms of DNA polymerase .delta. from calf thymus

Biochemistry ◽  
1986 ◽  
Vol 25 (24) ◽  
pp. 7821-7827 ◽  
Author(s):  
Alan F. Wahl ◽  
James J. Crute ◽  
Ralph D. Sabatino ◽  
John B. Bodner ◽  
Robert L. Marraccino ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Delta ◽  
Calf Thymus

scholarly journals The Largest Subunit of DNA Polymerase Delta Is Required for Normal Formation of Meiotic Type I Crossovers

2018 ◽  
Vol 179 (2) ◽  
pp. 446-459 ◽  
Author(s):  
Cong Wang ◽  
Jiyue Huang ◽  
Jun Zhang ◽  
Hongkuan Wang ◽  
Yapeng Han ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Type I ◽  
Dna Polymerase Delta
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