Kinetic isotope effects and ?metabolic switching? in cytochrome P450-catalyzed reactions

Gerald T. Miwa; Anthony Y. H. Lu

doi:10.1002/bies.950070506

Kinetic isotope effects and ?metabolic switching? in cytochrome P450-catalyzed reactions

BioEssays ◽

10.1002/bies.950070506 ◽

1987 ◽

Vol 7 (5) ◽

pp. 215-219 ◽

Cited By ~ 35

Author(s):

Gerald T. Miwa ◽

Anthony Y. H. Lu

Keyword(s):

Cytochrome P450 ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Metabolic Switching ◽

Catalyzed Reactions

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Kinetic isotope effects and their application in the mechanistic studies of some transition-metal-catalyzed reactions

Scientia Sinica Chimica ◽

10.1360/n032015-00254 ◽

2016 ◽

Vol 46 (6) ◽

pp. 573-578 ◽

Cited By ~ 1

Author(s):

Yujing Zhou ◽

Jian-Bo Wang

Keyword(s):

Transition Metal ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Mechanistic Studies ◽

Kinetic Isotope ◽

Transition Metal Catalyzed ◽

Catalyzed Reactions ◽

Metal Catalyzed

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Theoretical investigation on the mechanism and kinetic isotope effects of DBCP hydroxylation by cytochrome P450

Chinese Science Bulletin (Chinese Version) ◽

10.1360/972012-158 ◽

2012 ◽

Vol 57 (28-29) ◽

pp. 2699-2704

Author(s):

YuQin MA ◽

XingBao WANG ◽

JingWen CHEN ◽

Yong WANG

Keyword(s):

Cytochrome P450 ◽

Theoretical Investigation ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope

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Kinetic Isotope Effects in a C−H Bond Dissociation by the Iron-Oxo Species of Cytochrome P450

The Journal of Physical Chemistry B ◽

10.1021/jp001950+ ◽

2000 ◽

Vol 104 (51) ◽

pp. 12365-12370 ◽

Cited By ~ 21

Author(s):

Kazunari Yoshizawa ◽

Yoshihisa Kagawa ◽

Yoshihito Shiota

Keyword(s):

Cytochrome P450 ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Bond Dissociation ◽

Kinetic Isotope

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Kinetic Isotope Effects in Hydroxylation Reactions Effected by Cytochrome P450 Compounds I Implicate Multiple Electrophilic Oxidants for P450-Catalyzed Oxidations†

Biochemistry ◽

10.1021/bi802279d ◽

2009 ◽

Vol 48 (7) ◽

pp. 1620-1627 ◽

Cited By ~ 12

Author(s):

Xin Sheng ◽

Haoming Zhang ◽

Paul F. Hollenberg ◽

Martin Newcomb

Keyword(s):

Cytochrome P450 ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope

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Evidence for the general base mechanism in carboxypeptidase A-catalyzed reactions: partitioning studies on nucleophiles and H2(18)O kinetic isotope effects.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.80.14.4585 ◽

1983 ◽

Vol 80 (14) ◽

pp. 4585-4589 ◽

Cited By ~ 23

Author(s):

R. Breslow ◽

J. Chin ◽

D. Hilvert ◽

G. Trainor

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Carboxypeptidase A ◽

General Base ◽

Kinetic Isotope ◽

Base Mechanism ◽

Catalyzed Reactions

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pH Dependence and solvent deuterium oxide kinetic isotope effects on Bacillus cereus .beta.-lactamase I catalyzed reactions

Biochemistry ◽

10.1021/bi00301a041 ◽

1984 ◽

Vol 23 (6) ◽

pp. 1282-1287 ◽

Cited By ~ 11

Author(s):

Larry W. Hardy ◽

J. F. Kirsch

Keyword(s):

Bacillus Cereus ◽

Deuterium Oxide ◽

Isotope Effects ◽

Ph Dependence ◽

Kinetic Isotope Effects ◽

Beta Lactamase ◽

Kinetic Isotope ◽

Catalyzed Reactions

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KINETIC ISOTOPE EFFECTS IMPLICATE A SINGLE OXIDANT FOR CYTOCHROME P450-MEDIATED O-DEALKYLATION, N-OXYGENATION, AND AROMATIC HYDROXYLATION OF 6-METHOXYQUINOLINE

Drug Metabolism and Disposition ◽

10.1124/dmd.106.010280 ◽

2006 ◽

Vol 34 (8) ◽

pp. 1288-1290 ◽

Cited By ~ 14

Author(s):

Tamara S. Dowers ◽

Jeffrey P. Jones

Keyword(s):

Cytochrome P450 ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Aromatic Hydroxylation

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The expression of kinetic isotope effects during the time course of enzyme-catalyzed reactions

Bioorganic Chemistry ◽

10.1016/0045-2068(89)90018-7 ◽

1989 ◽

Vol 17 (2) ◽

pp. 177-193 ◽

Cited By ~ 17

Author(s):

Ronald G. Duggleby ◽

Dexter B. Northrop

Keyword(s):

Time Course ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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The Application of Transient-State Kinetic Isotope Effects to the Resolution of Mechanisms of Enzyme-Catalyzed Reactions

Molecules ◽

10.3390/molecules18078230 ◽

2013 ◽

Vol 18 (7) ◽

pp. 8230-8242 ◽

Cited By ~ 4

Author(s):

Harvey Fisher

Keyword(s):

Isotope Effects ◽

Transient State ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions ◽

State Kinetic

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CHAPTER 21. Molecular Dynamics Simulation of Kinetic Isotope Effects in Enzyme-Catalyzed Reactions

Theoretical and Computational Chemistry Series - Reaction Rate Constant Computations ◽

10.1039/9781849737753-00530 ◽

2013 ◽

pp. 530-549

Author(s):

Jiali Gao

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Dynamics Simulation ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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