Perirhinal cortex area 35 controls the functional link between the perirhinal and entorhinal‐hippocampal circuitry

BioEssays ◽  
2020 ◽  
pp. 2000084
Author(s):  
Riichi Kajiwara ◽  
Takashi Tominaga
Keyword(s):  
Perirhinal Cortex ◽  
Functional Link ◽  
Cortex Area ◽  
Hippocampal Circuitry

A direct projection from the perirhinal cortex (area 35) to the subiculum in the rat

1983 ◽  
Vol 269 (2) ◽  
pp. 347-351 ◽  
Author(s):  
Keith C. Kosel ◽  
Gary W. Van Hoesen ◽  
Douglas L. Rosene
Keyword(s):  
Perirhinal Cortex ◽  
Direct Projection ◽  
Cortex Area

Enhancement of Object Representations in Primate Perirhinal Cortex During a Visual Working-Memory Task

2007 ◽  
Vol 97 (2) ◽  
pp. 1298-1310 ◽  
Author(s):  
Sidney R. Lehky ◽  
Keiji Tanaka
Keyword(s):  
Brain Area ◽  
Memory Task ◽  
Perirhinal Cortex ◽  
The Other ◽  
Object Representations ◽  
Repetition Effects ◽  
Object Memory ◽  
Stimulus Response ◽  
Cortex Area ◽  
Area Te

We compared single-cell activities in perirhinal cortex (PRh) as well as adjacent visual cortex (area TE) across two tasks. One task required the monkey to identify any stimulus repetition within a sequence of object stimuli. In the other task, the same stimuli were presented, but the monkey didn’t have to remember them. PRh responses during the object-memory task were elevated relative to those during the second task. In TE, on the other hand, there were no significant task-related differences in responses. We did not observe task-related differences related to repetition effects in either brain area. The onset of the enhanced signal in PRh during the object-memory task occurred with a latency of 80 ms after the onset of the stimulus response, suggesting that it was the result of top-down feedback.

Investigating the functional link between TMEM165 and SPCA1

2019 ◽  
Vol 476 (21) ◽  
pp. 3281-3293 ◽  
Author(s):  
Elodie Lebredonchel ◽  
Marine Houdou ◽  
Hans-Heinrich Hoffmann ◽  
Kateryna Kondratska ◽  
Marie-Ange Krzewinski ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Complete Loss ◽  
Protein Family ◽  
Uncharacterized Protein ◽  
Functional Link ◽  
P Type

TMEM165 was highlighted in 2012 as the first member of the Uncharacterized Protein Family 0016 (UPF0016) related to human glycosylation diseases. Defects in TMEM165 are associated with strong Golgi glycosylation abnormalities. Our previous work has shown that TMEM165 rapidly degrades with supraphysiological manganese supplementation. In this paper, we establish a functional link between TMEM165 and SPCA1, the Golgi Ca2+/Mn2+ P-type ATPase pump. A nearly complete loss of TMEM165 was observed in SPCA1-deficient Hap1 cells. We demonstrate that TMEM165 was constitutively degraded in lysosomes in the absence of SPCA1. Complementation studies showed that TMEM165 abundance was directly dependent on SPCA1's function and more specifically its capacity to pump Mn2+ from the cytosol into the Golgi lumen. Among SPCA1 mutants that differentially impair Mn2+ and Ca2+ transport, only the Q747A mutant that favors Mn2+ pumping rescues the abundance and Golgi subcellular localization of TMEM165. Interestingly, the overexpression of SERCA2b also rescues the expression of TMEM165. Finally, this paper highlights that TMEM165 expression is linked to the function of SPCA1.

Is adult hippocampal neurogenesis really relevant for the treatment of psychiatric disorders?

2020 ◽  
Vol 18 ◽  
Author(s):  
Marco Carli ◽  
Stefano Aringhieri ◽  
Shivakumar Kolachalam ◽  
Biancamaria Longoni ◽  
Giovanna Grenno ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Emotional Processing ◽  
Imaging Techniques ◽  
Hippocampal Neurogenesis ◽  
Adult Brain ◽  
Adult Hippocampal Neurogenesis ◽  
Mood Stabilizers ◽  
Post Traumatic Stress ◽  
Newborn Neurons ◽  
Hippocampal Circuitry

: Adult neurogenesis consists in the generation of newborn neurons from neural stem cells taking place in the adult brain. In mammals, this process is limited to very few areas of the brain, and one of these neurogenic niches is the subgranular layer of the dentate gyrus (DG) of the hippocampus. Adult newborn neurons are generated from quiescent neural progenitors (QNPs), which differentiate through different steps into mature granule cells (GCs), to be finally integrated into the existing hippocampal circuitry. In animal models, adult hippocampal neurogenesis (AHN) is relevant for pattern discrimination, cognitive flexibility, emotional processing and resilience to stressful situations. Imaging techniques allow to visualize newborn neurons within the hippocampus through all their stages of development and differentiation. In humans, the evidence of AHN is more challenging, and, based on recent findings, it persists through the adulthood, even if it declines with age. Whether this process has an important role in human brain function and how it integrates into the existing hippocampal circuitry is still a matter of exciting debate. Importantly, AHN deficiency has been proposed to be relevant in many psychiatric disorders, including mood disorders, anxiety, post-traumatic stress disorder and schizophrenia. This review aims to investigate how AHN is altered in different psychiatric conditions and how pharmacological treatments can rescue this process. In fact, many psychoactive drugs, such as antidepressants, mood stabilizers and atypical antipsychotics (AAPs), can boost AHN with different results. In addition, some non-pharmacological approaches are discussed as well.

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