scholarly journals Understanding Human Lung Development through In Vitro Model Systems

BioEssays ◽  
2020 ◽  
Vol 42 (6) ◽  
pp. 2000006 ◽  
Author(s):  
Renee F. Conway ◽  
Tristan Frum ◽  
Ansley S. Conchola ◽  
Jason R. Spence
Keyword(s):  
Lung Development ◽  
In Vitro Model ◽  
Human Lung ◽  
Model Systems ◽  
Vitro Model

Human 3-dimensional liver organoids: in vitro model systems to study liver diseases

2020 ◽  
Author(s):  
H Gaitantzi ◽  
C Cai ◽  
S Asawa ◽  
K Böttcher ◽  
M Ebert ◽  
...  
Keyword(s):  
Liver Diseases ◽  
In Vitro Model ◽  
Model Systems ◽  
3 Dimensional ◽  
Vitro Model ◽  
Liver Organoids

scholarly journals In Vitro Model Systems for Exploring Oral Biofilms: From Single‐Species Populations to Complex Multi‐Species Communities

2021 ◽  
Author(s):  
Ting L. Luo ◽  
Michael E. Vanek ◽  
Carlos Gonzalez‐Cabezas ◽  
Carl F. Marrs ◽  
Betsy Foxman ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Single Species ◽  
Model Systems ◽  
Oral Biofilms ◽  
Vitro Model

scholarly journals Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Renata P Assis ◽  
Juliana FA Castro ◽  
Vânia O Gutierres ◽  
Carlos A Arcaro ◽  
Renata S Brotto ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Renal Function ◽  
In Vitro Model ◽  
Reactive Oxygen ◽  
Model Systems ◽  
Oxygen Species ◽  
Uremic Solutes ◽  
Function Management ◽  
Vitro Model

scholarly journals In Vitro Systems for Studying Different Genotypes/Sub-Genotypes of Hepatitis B Virus: Strengths and Limitations

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 353 ◽  
Author(s):  
Constance N. Wose Kinge ◽  
Nimisha H. Bhoola ◽  
Anna Kramvis
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
In Vitro Model ◽  
Antiviral Agents ◽  
Model Systems ◽  
Effective Vaccine ◽  
B Virus ◽  
In Vitro Systems ◽  
Vitro Model

Hepatitis B virus (HBV) infects the liver resulting in end stage liver disease, cirrhosis, and hepatocellular carcinoma. Despite an effective vaccine, HBV poses a serious health problem globally, accounting for 257 million chronic carriers. Unique features of HBV, including its narrow virus–host range and its hepatocyte tropism, have led to major challenges in the development of suitable in vivo and in vitro model systems to recapitulate the HBV replication cycle and to test various antiviral strategies. Moreover, HBV is classified into at least nine genotypes and 35 sub-genotypes with distinct geographical distributions and prevalence, which have different natural histories of infection, clinical manifestation, and response to current antiviral agents. Here, we review various in vitro systems used to study the molecular biology of the different (sub)genotypes of HBV and their response to antiviral agents, and we discuss their strengths and limitations. Despite the advances made, no system is ideal for pan-genotypic HBV research or drug development and therefore further improvement is required. It is necessary to establish a centralized repository of HBV-related generated materials, which are readily accessible to HBV researchers, with international collaboration toward advancement and development of in vitro model systems for testing new HBV antivirals to ensure their pan-genotypic and/or customized activity.

Development of in vitro model systems for destructive joint diseases. Novel strategies for establishing inflammatory pannus

1997 ◽  
Vol 40 (8) ◽  
pp. 1420-1428 ◽  
Author(s):  
Olaf Schultz ◽  
Gernot Keyszer ◽  
Josef Zacher ◽  
Michael Sittinger ◽  
Gerd R. Burmester
Keyword(s):  
In Vitro Model ◽  
Model Systems ◽  
Joint Diseases ◽  
Vitro Model
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