The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation

BioEssays ◽  
2020 ◽  
Vol 42 (2) ◽  
pp. 1900146 ◽  
Author(s):  
Michael Levin
Keyword(s):  
Biological Causation ◽  
Regenerative Repair

scholarly journals O paradigma científico no discurso da mídia brasileira sobre Zika e microcefalia

2018 ◽  
Vol 2 (1) ◽  
pp. 9
Author(s):  
Juliane Lopes Ferreira dos Santos ◽  
Denise Silva Matias ◽  
Nauana Nascimento Novais
Keyword(s):  
Control Measures ◽  
Scientific Paradigm ◽  
Scientific Debate ◽  
The Public ◽  
Emergency Situations ◽  
Biological Causation ◽  
The Media ◽  
The Subject ◽  
Official Sources ◽  
The Relationship

Introduction: In 2015 Brazil was surprised by an increase in the incidence of microcephaly, related by the Ministry of Health to Zika virus infection during pregnancy. This theme, which was notorious for public health, reached wide popular repercussion through the media. Objectives: To describe the presence of the scientific paradigm in the discourse of health professionals, researchers or journalists who inform the lay public about biological causation. Methodology: All the news made available on the digital platform of the Folha de São Paulo newspaper, containing the key term "Zika and microcephalia" and published between November 11, 2015 and March 4, 2016, was performed. Scientific elucidation on the subject. The news items were classified as to the presence of certainty or uncertainty about the relationship between Zika and microcephaly in their content and the central idea in the subject titles. Results: Of the 387 reports analyzed, 51.4% related Zika as a causal factor of microcephaly, while 32.8% considered the presence of uncertainty in the relationship. It was verified that the newspaper privileged subjects related to the repercussions due to the diseases, being predominant the report of control measures. Considering the origin of the news, it was significant the use of official sources, presented in 82% of the news. Conclusion: The scientific paradigm was disregarded, ignoring the uncertainty principle and the scientific debate. The limitations of both journalists and health managers were also demonstrated in the elaboration of an effective communication with the public in emergency situations.

scholarly journals Periosteum: The forgotten source of osteoprogenitors

2019 ◽  
Vol 37 (3) ◽  
pp. 22-23
Author(s):  
Matthew Stewart
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Bone Repair ◽  
Callus Formation ◽  
Intramembranous Bone ◽  
Morphogenetic Protein ◽  
Cambium Layer ◽  
Clinical Responses ◽  
Intramembranous Bone Formation ◽  
Regenerative Repair

Bone is one of the few tissues capable of authentic regenerative repair. However, despite advances in surgical technique, orthopaedic hardware and our understanding of fracture biology, inadequate bone repair remains a major concern in both veterinary and human medicine. Cell-based technologies provide opportunities to utilize the osteogenic capacities of Mesenchymal Stem Cells (MSC) to augment bone repair. Much of the research on MSC biology has focused on cells derived from the bone marrow/endosteal compartment; however, osteoprogenitor cells (OPC) also reside in the periosteum. Periosteum develops as a fibro-cellular envelope surrounding developing skeletal elements. The inner, or cambium layer of periosteum, includes committed OPCs directly adjacent the bone surface, and a distinct sub-population of progenitors within the periosteal mid-substance that retain both chondrogenic and osteogenic capacities. During skeletogenesis, periosteal OPCs are responsible for appositional intramembranous bone formation that increases the radial diameter of long bones. Of critical importance, periosteal stem cells are the predominant cell population responsible for generating the cartilaginous or ‘soft’ callus that provides intermediate stabilization and a scaffold for subsequent callus ossification by endochondral ossification; the primary mechanism of bone repair. In recent experiments using isolates from ‘donor-matched’ periosteum and bone marrow, we have found that the basal osteogenic capacity of equine OPCs is considerably less than that of bone marrow-derived MSCs. Periosteal OPCs require exogenous Bone Morphogenetic Protein (BMP) for robust osteogenesis, a finding consistent with the clinical responses of bone to recombinant BMP protein. Perhaps more surprising, the osteogenic capacity of adult (2-10 years of age) OPCs is comparable to those of young foals’, although the cell yield is considerably greater from foal specimens. In light of the vital importance of callus formation for successful fracture healing of most, further research on the biology and clinical manipulation of periosteal OPCs is highly warranted.

Gifted Adolescent Females Require Differential Treatment

1984 ◽  
Vol 8 (1) ◽  
pp. 43-58 ◽  
Author(s):  
Sharon J. Higham ◽  
Jane Navarre
Keyword(s):  
Cognitive Skills ◽  
Belief System ◽  
Adolescent Females ◽  
Differential Treatment ◽  
Visual Spatial ◽  
Biological Causation ◽  
Psychometric Data ◽  
Traditional Careers ◽  
Cognitive Patterns ◽  
Gifted Girls

How one responds to the issue of differential treatment for gifted girls depends upon one's belief system. Psychometric data indicate that sex-related differences in cognitive skills exist, particularly in the areas of mathematical and/or visual spatial ability. Although many theories proposing biological causation for these differences have been offered, there is no consensus among experts on this matter. Furthermore, the existence of different individual cognitive patterns within each sex, suggests that environmental factors are influential. Based on the literature reviewed, the authors present recommendations for parents and educators of gifted adolescent females. It is argued that differential treatment will produce more equitable education and the requisite skills to achieve success in both traditional and non-traditional careers.

The Role of Catalysis in Biological Causation

1943 ◽  
Vol 10 (3) ◽  
pp. 176-183 ◽  
Author(s):  
Edgar J. Witzemann
Keyword(s):  
Biological Causation

MTORC1-dependent reprogramming

2020 ◽  
Vol 13 (656) ◽  
pp. eabf4729
Author(s):  
Annalisa M. VanHook
Keyword(s):  
Regenerative Repair

DDIT4 and IFRD1 trigger the inhibition and reactivation of MTORC1 during regenerative repair.

New Process for Regeneration of Main Control Valve

2014 ◽  
Vol 635-637 ◽  
pp. 181-184
Author(s):  
Li Ming Cai
Keyword(s):  
Service Life ◽  
Hydraulic System ◽  
Control Valve ◽  
Maintenance Cost ◽  
Simple Process ◽  
New Process ◽  
Regenerative Repair

Main control valve is the key component of the hydraulic system, the valve value accounts for about 30% of machinery hydraulic system. The regenerative repair of main control valve was completed by adopting grinding, electroplating and other relatively simple process. So, process is easy to operation and implementation, the maintenance cost and waste of resources is decreased, and repair effect is good. The service life of main control valve regenerated by using this technology can reach or exceed the service life of new one.

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