scholarly journals Phase Separation and Transcription Regulation: Are Super-Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?

BioEssays ◽  
2018 ◽  
Vol 41 (1) ◽  
pp. 1800164 ◽  
Author(s):  
Aishwarya Gurumurthy ◽  
Yong Shen ◽  
Eliot M. Gunn ◽  
Jörg Bungert
Keyword(s):  
Phase Separation ◽  
Transcription Regulation ◽  
Complex Assembly ◽  
Locus Control Regions ◽  
Control Regions

Locus control regions

2003 ◽  
pp. 397-409
Author(s):  
Xiangdong Fang ◽  
Kenneth R. Peterson ◽  
Qiliang Li ◽  
George Stamatoyannopoulos
Keyword(s):  
Locus Control Regions ◽  
Control Regions

Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights

Gene ◽  
1997 ◽  
Vol 205 (1-2) ◽  
pp. 73-94 ◽  
Author(s):  
Ross Hardison ◽  
Jerry L. Slightom ◽  
Deborah L. Gumucio ◽  
Morris Goodman ◽  
Nikola Stojanovic ◽  
...  
Keyword(s):  
Phylogenetic Analyses ◽  
Globin Gene ◽  
Gene Clusters ◽  
Experimental Results ◽  
Locus Control Regions ◽  
Control Regions

A Systematic Bioinformatics Approach to Motif-Based Analysis of Human Locus Control Regions

2019 ◽  
Vol 26 (12) ◽  
pp. 1427-1437
Author(s):  
B. Sharan Sharma ◽  
Prabodha K. Swain ◽  
Ramtej J. Verma
Keyword(s):  
Locus Control Regions ◽  
Control Regions

Locus control regions: coming of age at a decade plus

1999 ◽  
Vol 15 (10) ◽  
pp. 403-408 ◽  
Author(s):  
Qiliang Li ◽  
Susanna Harju ◽  
Kenneth R. Peterson
Keyword(s):  
Coming Of Age ◽  
Locus Control Regions ◽  
Control Regions

scholarly journals Locus control regions

Blood ◽  
2002 ◽  
Vol 100 (9) ◽  
pp. 3077-3086 ◽  
Author(s):  
Qiliang Li ◽  
Kenneth R. Peterson ◽  
Xiangdong Fang ◽  
George Stamatoyannopoulos
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Cell Lineage ◽  
Regulatory Elements ◽  
Dependent Manner ◽  
Long Range Interactions ◽  
Eukaryotic Gene ◽  
Specific Regulation ◽  
Locus Control Regions ◽  
Control Regions

Abstract Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number–dependent manner at ectopic chromatin sites. Although their composition and locations relative to their cognate genes are different, LCRs have been described in a broad spectrum of mammalian gene systems, suggesting that they play an important role in the control of eukaryotic gene expression. The discovery of the LCR in the β-globin locus and the characterization of LCRs in other loci reinforces the concept that developmental and cell lineage–specific regulation of gene expression relies not on gene-proximal elements such as promoters, enhancers, and silencers exclusively, but also on long-range interactions of variouscis regulatory elements and dynamic chromatin alterations.

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