Adult neural stem cells: Long-term self-renewal, replenishment by the immune system, or both?

BioEssays ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 495-501 ◽  
Author(s):  
Barbara S. Beltz ◽  
Emily L. Cockey ◽  
Jingjing Li ◽  
Jody F. Platto ◽  
Kristina A. Ramos ◽  
...  
Keyword(s):  
Stem Cells ◽  
Immune System ◽  
Neural Stem Cells ◽  
Self Renewal ◽  
Adult Neural Stem Cells

scholarly journals UHRF1 Licensed Self-Renewal of Active Adult Neural Stem Cells

Stem Cells ◽  
2018 ◽  
Vol 36 (11) ◽  
pp. 1736-1751 ◽  
Author(s):  
Albert Blanchart ◽  
Anna C. Navis ◽  
Natalia Assaife-Lopes ◽  
Dmitry Usoskin ◽  
Sergi Aranda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Self Renewal ◽  
Adult Neural Stem Cells

scholarly journals Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells

2012 ◽  
Vol 125 (2) ◽  
pp. 295-309 ◽  
Author(s):  
B. N. Sheikh ◽  
M. P. Dixon ◽  
T. Thomas ◽  
A. K. Voss
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Self Renewal ◽  
Adult Neural Stem Cells

Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice

2019 ◽  
Vol 29 (5) ◽  
pp. 727-735 ◽  
Author(s):  
Yuhang Cao ◽  
Yingliang Zhuang ◽  
Junchen Chen ◽  
Weize Xu ◽  
Yikai Shou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Development ◽  
Conditional Knockout ◽  
Biological Processes ◽  
Adult Neural Stem Cells ◽  
Proliferation And Differentiation

Abstract N 6-methyladenosine (m6A) modification of RNA is deposited by the methyltransferase complex consisting of Mettl3 and Mettl14 and erased by demethylase Fto and Alkbh5 and is involved in diverse biological processes. However, it remains largely unknown the specific function and mechanism of Fto in regulating adult neural stem cells (aNSCs). In the present study, utilizing a conditional knockout (cKO) mouse model, we show that the specific ablation of Fto in aNSCs transiently increases the proliferation of aNSCs and promotes neuronal differentiation both in vitro and in vivo, but in a long term, the specific ablation of Fto inhibits adult neurogenesis and neuronal development. Mechanistically, Fto deficiency results in a significant increase in m6A modification in Pdgfra and Socs5. The increased expression of Pdgfra and decreased expression of Socs5 synergistically promote the phosphorylation of Stat3. The modulation of Pdgfra and Socs5 can rescue the neurogenic deficits induced by Fto depletion. Our results together reveal an important function of Fto in regulating aNSCs through modulating Pdgfra/Socs5-Stat3 pathway.

scholarly journals Immune System Modulates the Function of Adult Neural Stem Cells

2010 ◽  
Vol 6 (3) ◽  
pp. 167-173 ◽  
Author(s):  
Oscar Gonzalez-Perez ◽  
Fernando Jauregui-Huerta ◽  
Alma Yadira Galvez-Contreras
Keyword(s):  
Stem Cells ◽  
Immune System ◽  
Neural Stem Cells ◽  
Adult Neural Stem Cells

Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells

Development ◽  
2012 ◽  
Vol 139 (6) ◽  
pp. e607-e607
Author(s):  
B. N. Sheikh ◽  
M. P. Dixon ◽  
T. Thomas ◽  
A. K. Voss
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Self Renewal ◽  
Adult Neural Stem Cells

scholarly journals Long-term self-renewal of naïve neural stem cells in a defined condition

2019 ◽  
Vol 1866 (6) ◽  
pp. 971-977 ◽  
Author(s):  
Yongming Wu ◽  
Xi Chen ◽  
Guangjun Xi ◽  
Xingliang Zhou ◽  
Suyue Pan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Self Renewal
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