Erratum: Electromagnetic Irradiation Evokes Physiological and Molecular Alterations in Rice

The prevalence of heart failure is markedly increased in individuals with diabetes mellitus. Numerous observational studies suggest that this increased risk for heart failure can be attributed to exacerbated vascular complications and the presence of increased risk factors in diabetic subjects. In addition, experimental studies revealed the presence of a number of distinct molecular alterations in the myocardium that occur independently of vascular disease and hypertension. Many of these molecular alterations are similarly observed in failing hearts of nondiabetic patients and have thus been proposed to contribute to the increased risk for heart failure in diabetes. The interest in understanding the underlying mechanisms of impaired cardio- vascular outcomes in diabetic individuals has much increased since the demonstration of cardioprotective effects of SGLT-2 inhibitors and GLP-1 receptor agonists in recent clinical trials. The current review therefore summarizes the distinct mechanisms that have been proposed to increase the risk for heart failure in diabetes mellitus.

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Faculty Opinions recommendation of Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13479966.14859095 ◽

2012 ◽

Author(s):

Akemi Ishida-Yamamoto

Keyword(s):

Atopic Dermatitis ◽

Molecular Alterations ◽

Ichthyosis Vulgaris

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Elucidation of Molecular Alterations in Precursor Lesions of Ovarian Serous Carcinoma

10.21236/ada554207 ◽

2011 ◽

Author(s):

Robert J. Kurman

Keyword(s):

Serous Carcinoma ◽

Precursor Lesions ◽

Ovarian Serous Carcinoma ◽

Molecular Alterations

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Targeting Tumour Metastasis: The Emerging Role of Nanotechnology

Current Medicinal Chemistry ◽

10.2174/0929867326666181220095343 ◽

2020 ◽

Vol 27 (8) ◽

pp. 1367-1381 ◽

Cited By ~ 2

Author(s):

Sarah Visentin ◽

Mirela Sedić ◽

Sandra Kraljević Pavelić ◽

Krešimir Pavelić

Keyword(s):

Cancer Progression ◽

Metastatic Cancer ◽

Treatment Strategies ◽

Metastatic Progression ◽

Therapeutic Concept ◽

Molecular Alterations ◽

Tumour Metastasis ◽

Metastatic Cells ◽

Metastatic Process ◽

Underlying Mechanisms

The metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an overview of the current findings that shed light on specific molecular alterations associated with metastasis and present novel concepts in the treatment of the metastatic process. In particular, we discuss novel pharmacological approaches in the clinical setting that target metastatic progression. New insights into the process of metastasis allow optimisation and design of new treatment strategies, especially in view of the fact that metastatic cells share common features with stem cells. Nano- and micro-technologies are herein elaborated in details as a promising therapeutic concept in targeted drug delivery for metastatic cancer. Progression in the field could provide a more efficient way to tackle metastasis and thus bring about advancements in the treatment and management of patients with advanced cancer.

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Simultaneous genotypic and immunophenotypic analysis of interphase cells using dual-color fluorescence: a demonstration of lineage involvement in polycythemia vera

Blood ◽

10.1182/blood.v80.4.1033.1033 ◽

1992 ◽

Vol 80 (4) ◽

pp. 1033-1038 ◽

Cited By ~ 53

Author(s):

CM Price ◽

EJ Kanfer ◽

SM Colman ◽

N Westwood ◽

AJ Barrett ◽

...

Keyword(s):

Polycythemia Vera ◽

Fluorescent In Situ Hybridization ◽

Chromosomal Abnormalities ◽

Myeloproliferative Disorders ◽

Chromosome 8 ◽

Dual Fluorescence ◽

Interphase Cell ◽

Molecular Alterations ◽

Interphase Cells

Abstract Fluorescent in situ hybridization has become a useful technique by which chromosomal abnormalities may be shown in interphase cells. We present a dual-fluorescence method whereby a chromosomal and immunophenotypic marker can be visualized simultaneously in the same interphase cell. Two patients with the myeloproliferative disorder polycythemia vera and trisomy for chromosome 8 have been studied using this technique and selective involvement of the myeloid and erythrocyte lineages has been shown by the detection of the trisomy in immunophenotyped cells. Simultaneous analysis of genotype and immunophenotype in individual cells from patients with myeloproliferative disorders or leukemia may help identify the developmental and lineage status of cells in which molecular alterations have resulted in clonal advantage.

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