Prenatal exposure to environmental factors and congenital limb defects

2016 ◽  
Vol 108 (3) ◽  
pp. 243-273 ◽  
Author(s):  
Peter G. Alexander ◽  
Karen L. Clark ◽  
Rocky S. Tuan
Keyword(s):  
Environmental Factors ◽  
Prenatal Exposure ◽  
Limb Defects ◽  
Congenital Limb

scholarly journals Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects

Development ◽  
2008 ◽  
Vol 135 (7) ◽  
pp. 1377-1388 ◽  
Author(s):  
N. Lo Iacono ◽  
S. Mantero ◽  
A. Chiarelli ◽  
E. Garcia ◽  
A. A. Mills ◽  
...  
Keyword(s):  
Gene Expression ◽  
Limb Defects ◽  
Congenital Limb

Fetal Vascular Disruption With Prenatal Exposure to Cocaine or Methamphetamine

PEDIATRICS ◽  
1991 ◽  
Vol 87 (3) ◽  
pp. 417-418
Author(s):  
H. EUGENE HOYME
Keyword(s):  
Prenatal Exposure ◽  
Medical Records ◽  
Cocaine Abuse ◽  
Drug Exposure ◽  
Prenatal Drug Exposure ◽  
Fetal Exposure ◽  
Fetal Risk ◽  
Vascular Disruption ◽  
Limb Reduction ◽  
Congenital Limb

In Reply.— Dr Bays has pointed out that congenital limb reduction defects associated with prenatal exposure to cocaine may be quite common. I would agree that such limb and digital disruptions are occasional accompaniments of fetal exposure to maternal cocaine abuse. However, the exact magnitude of individual fetal risk for prenatal vascular disruption associated with such exposure remains to be delineated. One must take the percentage of cocaine-exposed children in this report as the minimal number of exposed because many of the medical records did not record prenatal drug exposure.

Prevalence and pattern of congenital limb defects in north of Iran

2015 ◽  
Vol 56 ◽  
pp. 30
Author(s):  
Mohammad Jafar Golalipour ◽  
Elaheh Golalipour ◽  
Nafiseh Kaviany ◽  
Aerzoo Mirfazeli ◽  
Naser Behnampour
Keyword(s):  
Limb Defects ◽  
North Of Iran ◽  
Congenital Limb

Management of the limb deficient child

2011 ◽  
Author(s):  
Peter Calder ◽  
Rajiv S. Hanspal
Keyword(s):  
Multidisciplinary Approach ◽  
Surgical Reconstruction ◽  
Limb Defects ◽  
Primary Amputation ◽  
Congenital Limb ◽  
Deficient Child

♦ The majority of congenital limb defects are sporadic and unilateral♦ The skeletal deficiency is described as transverse or longitudinal♦ A multidisciplinary approach to management is required♦ The balance between surgical reconstruction of the limb vs primary amputation is difficult to find.

scholarly journals Developmental Effects of Exposures to Environmental Factors: The Polish Mother and Child Cohort Study

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Kinga Polanska ◽  
Wojciech Hanke ◽  
Wojciech Sobala ◽  
Malgorzata Trzcinka-Ochocka ◽  
Danuta Ligocka ◽  
...  
Keyword(s):  
Cohort Study ◽  
Environmental Factors ◽  
Prenatal Exposure ◽  
Lead Exposure ◽  
Motor Development ◽  
Mercury Level ◽  
Lead Level ◽  
Psychomotor Development ◽  
Postnatal Exposure ◽  
Mother And Child

This paper estimates the effects of exposure to environmental factors, including lead, mercury, environmental tobacco smoke (ETS), and polycyclic aromatic hydrocarbons (PAH), on child psychomotor development. The study population consists of mother-child pairs in the Polish Mother and Child Cohort Study. Prenatal and postnatal exposure to environmental factors was determined from biomarker measurements as follows: for lead exposure—cord blood lead level, for mercury—maternal hair mercury level, for ETS—cotinine level in saliva and urine, and for PAH—1-hydroxypyrene (1-HP) in urine. At the age of 12 (406 subjects) and 24 months (198 subjects) children were assessed using Bayley Scales of Infant and Toddler Development. There were no statistically significant effects of prenatal exposure to mercury or 1-HP on child psychomotor development. After adjusting for potential confounders, adverse effects of prenatal exposure to ETS on motor development (β= −2.6;P=0.02) and postnatal exposure to ETS on cognitive (β= −0.2;P=0.05) and motor functions (β= −0.5;P=0.01) were found. The adverse effect of prenatal lead exposure on cognitive score was of borderline significance (β= −6.2;P=0.06). The study underscores the importance of policies and public health interventions that aim to reduce prenatal and postnatal exposure to lead and ETS.

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