Impact of fetal alcohol exposure on body systems: A systematic review

2016 ◽  
Vol 108 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Courtney Caputo ◽  
Erin Wood ◽  
Leila Jabbour
Keyword(s):  
Systematic Review ◽  
Alcohol Exposure ◽  
Fetal Alcohol Exposure ◽  
Fetal Alcohol

scholarly journals Adverse reproductive outcomes associated with fetal alcohol exposure: a systematic review

Reproduction ◽  
2019 ◽  
Vol 157 (4) ◽  
pp. 329-343 ◽  
Author(s):  
L K Akison ◽  
K M Moritz ◽  
N Reid
Keyword(s):  
Systematic Review ◽  
Alcohol Exposure ◽  
Spectrum Disorder ◽  
Reproductive Age ◽  
Preclinical Studies ◽  
Reproductive Outcomes ◽  
Fetal Alcohol Exposure ◽  
Fetal Alcohol ◽  
Wide Range ◽  
Prenatal Alcohol

Fetal alcohol exposure results in well-characterised neurobehavioural deficits in offspring, which form the basis for diagnosing fetal alcohol spectrum disorder. However, there is increasing interest in the full range of health complications that can arise in children and adults with this disorder. We used a systematic review approach to locate all clinical and preclinical studies across a broad range of health outcomes in offspring exposed to prenatal alcohol. Our search encompassed four databases (PubMed, CINAHL, EMBASE and Web of Science) and titles/abstracts from retrieved studies were screened against strict inclusion/exclusion criteria. This review specifically evaluated studies reporting on reproductive outcomes in both males and females. A total of 23 studies were included, 5 clinical and 18 preclinical. Although there was a wide range in the quality of reporting across both clinical and preclinical studies, and variable results, trends emerged amongst the reproductive measures that were investigated. In females, most studies focussed on age at first menarche/puberty onset, with evidence for a significant delay in alcohol-exposed offspring. In males, offspring exposed to prenatal alcohol had altered testosterone levels, reduced testes and accessory gland weights and reduced sperm concentration and semen volume. However, further studies are required due to the paucity of clinical studies, the narrow scope of female reproductive outcomes examined and inconsistencies in outcomes across preclinical studies. We recommend that adolescents and individuals of reproductive age diagnosed with f-etal alcohol spectrum disorder be assessed for reproductive dysfunction to allow appropriate management of their reproductive health and fertility.

scholarly journals Fetal Alcohol Exposure Disrupts Metabolic Signaling in Hypothalamic Proopiomelanocortin Neurons via a Circadian Mechanism in Male Mice

Endocrinology ◽  
2014 ◽  
Vol 155 (7) ◽  
pp. 2578-2588 ◽  
Author(s):  
Maria A. Agapito ◽  
Changqing Zhang ◽  
Sengottuvelan Murugan ◽  
Dipak K. Sarkar
Keyword(s):  
Alcohol Exposure ◽  
Male Mice ◽  
Fetal Alcohol Exposure ◽  
Fetal Alcohol ◽  
Metabolic Signaling

Prevalence of heavy fetal alcohol exposure by analysis of meconium fatty acid ethyl esters; A nat ionwide canadian study

2018 ◽  
Vol 80 ◽  
pp. 142
Author(s):  
Kaithlyn Delano ◽  
Gideon Koren ◽  
Martin Zack ◽  
Bhushan Kapur ◽  
Joey Gareri ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Alcohol Exposure ◽  
Fatty Acid Ethyl Esters ◽  
Ethyl Esters ◽  
Fetal Alcohol Exposure ◽  
Canadian Study ◽  
Fetal Alcohol

scholarly journals Fetal Alcohol Exposure Increases Mammary Tumor Susceptibility and Alters Tumor Phenotype in Rats

2010 ◽  
Vol 34 (11) ◽  
pp. 1879-1887 ◽  
Author(s):  
Tiffany A. Polanco ◽  
Catina Crismale-Gann ◽  
Kenneth R. Reuhl ◽  
Dipak K. Sarkar ◽  
Wendie S. Cohick
Keyword(s):  
Mammary Tumor ◽  
Alcohol Exposure ◽  
Fetal Alcohol Exposure ◽  
Fetal Alcohol ◽  
Tumor Susceptibility ◽  
Tumor Phenotype

scholarly journals Fetal Alcohol Exposure: The Common Toll

2017 ◽  
Vol 05 (01) ◽  
Author(s):  
Marie R Nakhoul ◽  
Karl E Seif ◽  
Natasha Haddad ◽  
Georges E Haddad
Keyword(s):  
Alcohol Exposure ◽  
Fetal Alcohol Exposure ◽  
Fetal Alcohol ◽  
The Common

scholarly journals Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice

2013 ◽  
Vol 6 (4) ◽  
pp. 977-992 ◽  
Author(s):  
B. I. Laufer ◽  
K. Mantha ◽  
M. L. Kleiber ◽  
E. J. Diehl ◽  
S. M. F. Addison ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Alcohol Exposure ◽  
Fetal Alcohol Exposure ◽  
Fetal Alcohol
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