Gestational surrogacy and the role of routine embryo screening: Current challenges and future directions for preimplantation genetic testing

2015 ◽  
Vol 108 (1) ◽  
pp. 98-102 ◽  
Author(s):  
E. Scott Sills ◽  
Robert E. Anderson ◽  
Mary McCaffrey ◽  
Xiang Li ◽  
Nabil Arrach ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Preimplantation Genetic Testing ◽  
Future Directions ◽  
Gestational Surrogacy

scholarly journals Prognostic role of preimplantation genetic testing for aneuploidy in medically indicated fertility preservation

2020 ◽  
Vol 113 (2) ◽  
pp. 408-416 ◽  
Author(s):  
Jennifer K. Blakemore ◽  
Emma C. Trawick ◽  
James A. Grifo ◽  
Kara N. Goldman
Keyword(s):  
Genetic Testing ◽  
Fertility Preservation ◽  
Prognostic Role ◽  
Preimplantation Genetic Testing

scholarly journals Preimplantation genetic testing

2021 ◽  
Vol 2 (2) ◽  
pp. 52-63
Author(s):  
Ana Jeremić ◽  
Dragana Vuković ◽  
Srna Subanović ◽  
Jovana Broćić ◽  
Biljana Macanović
Keyword(s):  
Genetic Testing ◽  
In Vitro Fertilization ◽  
Success Rate ◽  
Embryo Transfer ◽  
Trinucleotide Repeat ◽  
Chromosomal Abnormalities ◽  
Preimplantation Genetic Testing ◽  
Vitro Fertilization

The application of preimplantation genetic testing (PGT) began in the late 1980s. Pre-implantation genetic testing, as the earliest possible method of prenatal diagnosis, enables the selection of embryos with a normal karyotype for embryo transfer. The use of preimplantation genetic testing has proven to be a useful method in the following three groups of inherited diseases: monogenic disorders (single gene defects), trinucleotide repeat disorders, and chromosomal abnormalities. The success rate of in vitro fertilization (IVF) has increased significantly since the introduction of PGT into clinical practice. This paper presents a literature review with the aim of clearly determining the role of PGT in embryo selection before embryo transfer, as well as the role of this type of testing in increasing the success rate of IVF. One of the goals of the paper is also to review the development of molecular genetic methods that are currently, or have once been, in routine use when performing PGT. The current literature is an indicator of the development and progress of molecular genetics techniques applied in PGT. At the same time, it provides an opportunity and an incentive for further extensive research that will lead to the improvement of preimplantation genetic testing and thus increase the success rate of in vitro fertilization.

scholarly journals Role of aneuploidy screening in preimplantation genetic testing for monogenic diseases in young women

2019 ◽  
Vol 111 (5) ◽  
pp. 928-935 ◽  
Author(s):  
Wenhui Hou ◽  
Yan Xu ◽  
Rong Li ◽  
Junli Song ◽  
Jing Wang ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Young Women ◽  
Aneuploidy Screening ◽  
Preimplantation Genetic Testing ◽  
Monogenic Diseases

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

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