Activator-inhibitor dynamics of vertebrate limb pattern formation

2007 ◽  
Vol 81 (4) ◽  
pp. 305-319 ◽  
Author(s):  
Stuart A. Newman ◽  
Ramray Bhat
Keyword(s):  
Pattern Formation ◽  
Vertebrate Limb ◽  
Limb Pattern ◽  
Activator Inhibitor

Symmetrical vascularization patterns in normal and retinoic acid treated limb regenerates of the axolotl, Ambystoma mexicanum

1998 ◽  
Vol 76 (9) ◽  
pp. 1795-1796 ◽  
Author(s):  
Steven R Scadding ◽  
Andrew Burns
Keyword(s):  
Retinoic Acid ◽  
Pattern Formation ◽  
Vascular System ◽  
Limb Regeneration ◽  
Ambystoma Mexicanum ◽  
Limb Pattern ◽  
Regeneration Blastema

The purpose of this investigation was to determine whether there were any asymmetries in the vascularization of the limb-regeneration blastema in the axolotl, Ambystoma mexicanum, that might be related to pattern formation, and to determine if retinoic acid could modify the vascular patterns of the blastema. We used acrylic casts of the vascular system of the limbs to assess the pattern of vascularization. We observed a very regular symmetrical arrangement of capillaries in the limb-regeneration blastema that did not appear to be modified by doses of retinoic acid sufficient to modify the limb pattern.

Retinoic Acid and Limb Pattern Formation in Cell Culture

1991 ◽  
pp. 105-113
Author(s):  
Hiroyuki Ide ◽  
Yasushi Ohkubo ◽  
Sumihare Noji ◽  
Shigehiko Taniguchi
Keyword(s):  
Cell Culture ◽  
Retinoic Acid ◽  
Pattern Formation ◽  
Limb Pattern

Morphogenesis of the amphibian limb blastema: The relationship between pattern and form

Development ◽  
1984 ◽  
Vol 79 (1) ◽  
pp. 165-181
Author(s):  
Nigel Holder ◽  
Susan Reynolds
Keyword(s):  
Pattern Formation ◽  
Vitamin A ◽  
Short Range ◽  
Range Cell ◽  
Limb Pattern ◽  
The Relationship ◽  
Pattern Regulation ◽  
Thigh Region ◽  
Short Arc ◽  
Number Of Cells

A relationship between pattern formation and field shape is established following the formation of rounded blastemas on lower arm limb stumps after treatment with vitamin A. Pattern formation is not affected by alteration in blastemal shape caused by removal of the dermis from the thigh region of the leg. We conclude, therefore, that blastemal shape does not play a causal role in establishing limb pattern. Data relating the number of cells present between the cardinal axial poles of blastemas and the size of blastemas is discussed in terms of short arc intercalation and short range cell—cell interactions during pattern regulation.

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