Placental Transfer of a Fully Human IgG2 Monoclonal Antibody in the Cynomolgus Monkey, Rat, and Rabbit: A Comparative Assessment from during Organogenesis to Late Gestation

2014 ◽  
Vol 101 (2) ◽  
pp. 178-188 ◽  
Author(s):  
Graeme J. Moffat ◽  
Marc W. Retter ◽  
Gayle Kwon ◽  
Mark Loomis ◽  
M. Benjamin Hock ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cynomolgus Monkey ◽  
Placental Transfer ◽  
Comparative Assessment ◽  
Late Gestation

scholarly journals Efficient Mother-to-Child Transfer of Antiretroviral Immunity in the Context of Preclinical Monoclonal Antibody-Based Immunotherapy

2006 ◽  
Vol 80 (20) ◽  
pp. 10191-10200 ◽  
Author(s):  
Laurent Gros ◽  
Mireia Pelegrin ◽  
Marc Plays ◽  
Marc Piechaczyk
Keyword(s):  
Monoclonal Antibody ◽  
Viral Load ◽  
Immune Responses ◽  
Placental Transfer ◽  
Humoral Response ◽  
Antiviral Effect ◽  
Late Gestation ◽  
Adult Age ◽  
Therapeutic Consequences ◽  
Neutralizing Monoclonal Antibody

ABSTRACT When mice under the age of 5 to 6 days are infected, the FrCasE retrovirus induces a neurodegenerative disease leading to death within 1 to 2 months. We have recently reported that transient treatment with a neutralizing monoclonal antibody (MAb) shortly after infection, in addition to an expected immediate decrease in the viral load, also favors the development of a strong protective immune response that persists long after the MAb has been cleared. This observation may have important therapeutic consequences, as it suggests that MAbs might be used, not only as direct neutralizing agents, but also as immunomodulatory agents enabling patients to mount their own antiviral immune responses. We have investigated whether immunoglobulins from mothers who displayed a strong anti-FrCasE humoral response induced upon MAb treatment could affect both viremia and the immune systems of FrCasE-infected pups till adult age upon placental and/or breastfeeding transfer. The strongest effects, i.e., reduction in the viral load and induction of protective humoral antiviral responses, were observed upon breastfeeding alone and breastfeeding plus placental immunity transfer. However, placental transfer of anti-FrCasE antibodies was sufficient to both protect neonatally infected animals and help them initiate a neutralizing anti-FrCasE response. Also, administration of a neutralizing MAb to naive mothers during late gestation and breastfeeding could generate similar effects. Taken together, our data support the concept that passive immunotherapies during late gestation and/or breastfeeding might help retrovirally infected neonates prime their own protective immune responses, in addition to exerting an immediate antiviral effect.

Comparative Assessment of Fumonisin in Grain-Based Foods by ELISA, GC-MS, and HPLC

1994 ◽  
Vol 57 (2) ◽  
pp. 169-172 ◽  
Author(s):  
JAMES J. PESTKA ◽  
JUAN I. AZCONA-OLIVERA ◽  
RONALD D. PLATTNER ◽  
FIORENZA MINERVINI ◽  
M. BRUNO DOKO ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Food Samples ◽  
Comparative Assessment ◽  
The Other ◽  
Gas Chromatography Mass Spectrometry ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cereal Samples ◽  
Related Compounds ◽  
Positive Results

Seventy-one (71) food samples were analyzed for the mycotoxin fumonisin by a monoclonal antibody based competitive enzyme-linked immunosorbent assay (ELISA). Fumonisins were detected primarily in corn-based products with 7/12, 2/2 and 1/3 and 1/7 yellow cornmeal, blue cornmeal, corn muffin mix, and mixed grain cereal samples yielding positive results, respectively. When the positive samples and randomly selected negative samples were assessed by other methods, correlations (r values) between ELISA and gas chromatography-mass spectrometry (GC-MS), ELISA and high-pressure liquid chromatography (HPLC) and GC-MS and HPLC were 0.478 (p < 0.05), 0.512 (p < 0.05), and 0.946 (p < 0.01), respectively. The results suggested that although the immunoassay could be used for screening of fumonisin in food samples, higher estimates were attained by ELISA than by the other two methods particularly in the more contaminated samples. These observations may result from differences in sample preparation among the methods or because of the presence of structurally related compounds in extracts that are detectable by ELISA but not the other two methods.

scholarly journals Effect of anti-CD20 monoclonal antibody, Rituxan, on cynomolgus monkey and human B cells in a whole blood matrix

Cytometry ◽  
2003 ◽  
Vol 52A (2) ◽  
pp. 101-109 ◽  
Author(s):  
Yulia Vugmeyster ◽  
Kathy Howell ◽  
Anahid Bakshl ◽  
Clarissa Flores ◽  
Eleanor Canova-Davis
Keyword(s):  
Monoclonal Antibody ◽  
B Cells ◽  
Whole Blood ◽  
Cynomolgus Monkey ◽  
Human B Cells ◽  
Anti Cd20

Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late-gestation pregnant sheep

1993 ◽  
Vol 169 (4) ◽  
pp. 897-902 ◽  
Author(s):  
Phillip C. Greig ◽  
G. Angela Massmann ◽  
Keith T. Demarest ◽  
Raymond C. Weglein ◽  
Mary L. Holland ◽  
...  
Keyword(s):  
Placental Transfer ◽  
Cardiovascular Effects ◽  
Late Gestation ◽  
Pregnant Sheep ◽  
Oxytocin Antagonist

scholarly journals THE PLACENTAL TRANSFER OF IgG IN THE CYNOMOLGUS MONKEY

1983 ◽  
Vol 36 (3) ◽  
pp. 171-176 ◽  
Author(s):  
KOJI FUJIMOTO ◽  
KEIJI TERAO ◽  
FUMIAKI CHO ◽  
SHIGEO HONJO
Keyword(s):  
Cynomolgus Monkey ◽  
Placental Transfer

Utero-Placental Transfer of Octanoic, Palmitic and Linoleic Acids during Late Gestation in Gilts

1989 ◽  
Vol 67 (3) ◽  
pp. 738 ◽  
Author(s):  
A. J. Thulin ◽  
G. L. Allee ◽  
D. L. Harmon ◽  
D. L. Davis
Keyword(s):  
Placental Transfer ◽  
Late Gestation

PDGFRα monoclonal antibody: Assessment of embryo-fetal toxicity and time-dependent placental transfer of a murine surrogate antibody of olaratumab in mice

2018 ◽  
Vol 110 (18) ◽  
pp. 1358-1371 ◽  
Author(s):  
Debra Luffer-Atlas ◽  
Vijayapal R. Reddy ◽  
Kim G. Hilbish ◽  
Curtis E. Grace ◽  
William J Breslin
Keyword(s):  
Monoclonal Antibody ◽  
Placental Transfer ◽  
Time Dependent ◽  
Fetal Toxicity

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation1

2004 ◽  
Vol 77 (5) ◽  
pp. 717-726 ◽  
Author(s):  
Walter Schuler ◽  
Marc Bigaud ◽  
Volker Brinkmann ◽  
Franco Di Padova ◽  
Sabine Geisse ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cynomolgus Monkey ◽  
Efficacy And Safety
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