Effects of natalizumab, an α4 integrin inhibitor, on fertility in male and female guinea pigs

2009 ◽  
Vol 86 (2) ◽  
pp. 108-116 ◽  
Author(s):  
Nancy G. Wehner ◽  
Michael Skov ◽  
George Shopp ◽  
Meredith S. Rocca ◽  
Janet Clarke
Keyword(s):  
Guinea Pigs ◽  
Male And Female ◽  
Integrin Inhibitor

STUDIES ON RESPONSES OF INTERMEDIATE HOSTS TO INFECTION WITH TAENIA CRASSICEPS (ZEDER, 1800) (CESTODA)

1964 ◽  
Vol 42 (3) ◽  
pp. 367-385 ◽  
Author(s):  
Reino S. Freeman
Keyword(s):  
Mast Cells ◽  
Guinea Pigs ◽  
Intraperitoneal Injection ◽  
Peritoneal Fluid ◽  
Intermediate Hosts ◽  
Normal Range ◽  
Male And Female ◽  
Taenia Crassiceps ◽  
Blood Eosinophilia ◽  
Female Mice

Male and female mice developed a leucocytosis in peritoneal fluid and blood after intraperitoneal injection with cysticerci of Taenia crassiceps. Free mast cells declined intraperitoneally from normal range of 650 to 1500 cells per cu. mm to less than 100 per cu. mm; eosinophils increased from less than 100 per cu. mm to 95,000 per cu. mm, with a logarithmic rise during the first 1 to 2 weeks in mice overcoming the cysticerci. Cells of the monocyte–lymphocyte series also increased intraperitoneally, but heterophils remained scarce. Leucocytosis and eosinophilia were most pronounced in mice just overcoming cysticerci, less when cysticerci were alive, and least when cysticerci were overcome. Males generally developed higher eosinophilia faster than females and overcame cysticerci more successfully. Females which were fed eggs developed peripheral eosinopenia during the first 2 weeks, then changed to an eosinophilia without concomitant leucocytosis. Those mice which develop high eosinophilia quickly overcome injected cysticerci most successfully. Female mice with intraperitoneal cysticerci showed strong resistance against challenge feedings of eggs 28 days later, but were less resistant after only 14 days. Mate and female guinea pigs, which are refractory to intraperitoneally injected cysticerci, developed a blood eosinophilia, and eosinophilia and leucocytosis in the peritoneal fluid. No free mast cells were seen.

CHANGES IN THE CONCENTRATIONS OF CORTISOL AND CORTICOSTERONE IN THE PLASMA AND ADRENAL GLANDS OF THE GUINEA-PIG FROM BIRTH TO WEANING

1974 ◽  
Vol 63 (3) ◽  
pp. 483-488 ◽  
Author(s):  
M. DALLE ◽  
P. DELOST
Keyword(s):  
Adrenal Gland ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Plasma Cortisol ◽  
Adrenal Glands ◽  
Post Partum ◽  
Cortisol Secretion ◽  
Male And Female ◽  
Steady Level ◽  
Very High

SUMMARY Concentrations of cortisol and corticosterone in the plasma and adrenal glands of male and female guinea-pigs were estimated throughout the first postnatal day and thereafter at intervals up to 3 weeks of age. In the guinea-pig, the basal level of cortisol secretion is established more slowly than in other species. The concentration of plasma cortisol is very high at birth, with a marked fall between days 1 and 10 post partum and then a steady level from day 10 to 20, the time of weaning. At day 10 the values for plasma cortisol and corticosterone approach the lower ones found in the adult. There were peaks in the amounts of corticosteroids found in the adrenal gland at 50 h, 4 and 7 days and these may have been due to increased hormonal synthesis between days 2 and 8.

Characterization of ventricular repolarization in male and female guinea pigs

2007 ◽  
Vol 42 (2) ◽  
pp. 357-366 ◽  
Author(s):  
Judith Brouillette ◽  
Marie-Andrée Lupien ◽  
Chantale St-Michel ◽  
Céline Fiset
Keyword(s):  
Guinea Pigs ◽  
Ventricular Repolarization ◽  
Male And Female

scholarly journals Differential proteomic analysis of tibial subchondral bone from male and female guinea pigs with spontaneous osteoarthritis

2021 ◽  
Vol 21 (6) ◽  
Author(s):  
Ying Wang ◽  
Chengai Wu ◽  
Jianfeng Tao ◽  
Danhui Zhao ◽  
Xu Jiang ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Proteomic Analysis ◽  
Guinea Pigs ◽  
Male And Female

THE ROLE OF TESTOSTERONE AND ANDROSTENEDIONE AS PRECURSORS OF EPITESTOSTERONE IN GUINEA PIGS (IN VIVO AND IN VITRO STUDIES)

1971 ◽  
Vol 67 (1) ◽  
pp. 187-196 ◽  
Author(s):  
Marian Szamatowicz ◽  
Michel Drosdowsky ◽  
Max F. Jayle
Keyword(s):  
Sex Differences ◽  
Guinea Pigs ◽  
In Vitro Studies ◽  
Male And Female ◽  
Testosterone Production ◽  
Liver Slices

ABSTRACT After injection of [7α-3H] androstenedione and [4-14C] testosterone into male and female guinea pigs, doubly labelled aetiocholanolone, 5α-androstanedione and epiandrosterone were identified in the urine. No epitestosterone was detected. Ovaries, testes, adrenals and liver slices were incubated with the same precursors. Epitestosterone production was observed in all organs except in the adrenals. According to the epitestosterone 3H/14C ratio, it can be concluded that in guinea pigs an interconversion of testosterone, androstenedione and epitestosterone takes place. In liver, androstenedione is preferentially converted to epitestosterone without sex differences, whereas in ovary and testis epitestosterone derives preferentially from testosterone.

Mortality Rate in Male and Female Guinea-pigs on a Scorbutogenic Diet

Nature ◽  
1973 ◽  
Vol 242 (5399) ◽  
pp. 522-523 ◽  
Author(s):  
M. J. BARNES ◽  
B. J. CONSTABLE ◽  
S. G. IMPEY ◽  
E. KODICEK
Keyword(s):  
Mortality Rate ◽  
Guinea Pigs ◽  
Male And Female

Daily variations in phenylalanine hydroxylase activity in male and female guinea pigs

Life Sciences ◽  
1972 ◽  
Vol 11 (10) ◽  
pp. 533-539 ◽  
Author(s):  
Dan M. Sullivan ◽  
Michael J. Carver ◽  
John H. Copenhaver
Keyword(s):  
Guinea Pigs ◽  
Phenylalanine Hydroxylase ◽  
Hydroxylase Activity ◽  
Male And Female ◽  
Daily Variations
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