Teratology study of derivatives of tetramethylcyclopropyl amide analogues of valproic acid in mice

2006 ◽  
Vol 77 (3) ◽  
pp. 227-233 ◽  
Author(s):  
Akinobu Okada ◽  
Yuko Onishi ◽  
Yoshinobu Aoki ◽  
Boris Yagen ◽  
Eyal Sobol ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Derivatives Of

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity

2012 ◽  
Vol 227 (10) ◽  
pp. 3389-3396 ◽  
Author(s):  
Anna Tesei ◽  
Giovanni Brigliadori ◽  
Silvia Carloni ◽  
Francesco Fabbri ◽  
Paola Ulivi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Valproic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Hdac Inhibitor ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Derivatives Of

scholarly journals Effects of Ethyl Ester Derivatives of Valproic Acid Metabolites on Pentylenetetrazol Seizures in Mice

1981 ◽  
Vol 8 (3) ◽  
pp. 259-261 ◽  
Author(s):  
J. Bruni ◽  
E.J. Hammond ◽  
B.J. Wilder
Keyword(s):  
Valproic Acid ◽  
Ethyl Ester ◽  
Adult Male ◽  
Anticonvulsant Activity ◽  
Ethyl Esters ◽  
Icr Mice ◽  
Acid Metabolites ◽  
Pentylenetetrazol Seizures ◽  
Derivatives Of

SUMMARY:The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice. The ethyl ester 3-hydroxy-propylpentanoic acid was found to possess significant anticonvulsant activity.

scholarly journals Potent neuroprotective effects of novel structural derivatives of valproic acid: Potential roles of HDAC inhibition and HSP70 induction

2010 ◽  
Vol 476 (3) ◽  
pp. 127-132 ◽  
Author(s):  
Yan Leng ◽  
Zoya Marinova ◽  
Marcos A. Reis-Fernandes ◽  
Heinz Nau ◽  
De-Maw Chuang
Keyword(s):  
Valproic Acid ◽  
Hdac Inhibition ◽  
Neuroprotective Effects ◽  
Acid Potential ◽  
Derivatives Of ◽  
Hsp70 Induction

Theoretical characterization of SOME amides and esters DERIVATIVES of valproic acid

2009 ◽  
Vol 16 (2) ◽  
pp. 343-359 ◽  
Author(s):  
Nieves C. Comelli ◽  
Patricio Fuentealba ◽  
Eduardo A. Castro ◽  
Alicia H. Jubert
Keyword(s):  
Valproic Acid ◽  
Theoretical Characterization ◽  
Derivatives Of

Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide — Amide derivatives of valproic acid

2015 ◽  
Vol 46 ◽  
pp. 72-78 ◽  
Author(s):  
Hafiz Mawasi ◽  
Tawfeeq Shekh-Ahmad ◽  
Richard H. Finnell ◽  
Bogdan J. Wlodarczyk ◽  
Meir Bialer
Keyword(s):  
Valproic Acid ◽  
Pharmacokinetic Analysis ◽  
Amide Derivatives ◽  
Derivatives Of

Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid

2011 ◽  
Vol 22 (3) ◽  
pp. 461-468 ◽  
Author(s):  
Neta Pessah ◽  
Boris Yagen ◽  
Naama Hen ◽  
Jakob A. Shimshoni ◽  
Bogdan Wlodarczyk ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Pharmacological Activity ◽  
Amide Derivatives ◽  
Derivatives Of

scholarly journals Synthesis of a novel amide derivative of valproic acid and 1,3,4-thiadiazole with antiepileptic activity

2020 ◽  
pp. 75-80 ◽  
Author(s):  
A.S. Malygin ◽  
M.A. Demidova ◽  
S.Ya. Skachilova ◽  
E.V. Shilova
Keyword(s):  
Valproic Acid ◽  
High Performance ◽  
Therapeutic Index ◽  
Probit Analysis ◽  
Great Promise ◽  
Antiepileptic Activity ◽  
Amide Derivative ◽  
Amide Derivatives ◽  
Derivatives Of ◽  
Acid Structure

Valproates are commonly used to treat various forms of epilepsy. Problems accompanying their clinical application include drug resistance, adverse effects, acute and chronic toxicity. Safer anticonvulsants with improved efficacy can be obtained through the chemical modification of valproic acid structure. Thiadiazole-linked amide derivatives of valproates hold great promise because 1,3,4-thiadiazole can improve the drug’s bioavailability and reduce its toxicity. The aim of this work was to synthesize a novel amide derivative of valproic acid and 1,3,4-thiadiazole exerting antiepileptic activity. The chemical structure of the synthesized valproate was studied by IR, proton NMR and 13С-NMR-spectroscopy, mass spectroscopy and elemental analysis. The purity and individuality of the compound was confirmed by thin-layer and high-performance liquid chromatography. Its antiepileptic activity was assessed in the test with intraperitoneally injected 250 mg/kg isoniazid and subsequent Probit analysis. The synthesized N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propyl pentane amide (valprazolamide) had the following characteristics. ESI+MS: m/z 256.1 [M + H]+; MRM transitions: m/z 256.1 — m/z 81.0 and m/z 130.1. The valproate exerted antiepileptic activity against isoniazid-induced seizures in mice. In the test with isoniazid, ED50 of intraperitoneally injected VPZ was 126.8 mg/kg (95% CI: 65.5–245.4). Its therapeutic index was 7.3.

scholarly journals Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid

Epilepsia ◽  
2014 ◽  
Vol 55 (12) ◽  
pp. 1944-1952 ◽  
Author(s):  
Tawfeeq Shekh-Ahmad ◽  
Hafiz Mawasi ◽  
John H. McDonough ◽  
Richard H. Finnell ◽  
Bogdan J. Wlodarczyk ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Pharmacokinetic Analysis ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document