scholarly journals Estimate of the potential impact of folic acid fortification of corn masa flour on the prevention of neural tube defects

2013 ◽  
Vol 97 (10) ◽  
pp. 649-657 ◽  
Author(s):  
Sarah C. Tinker ◽  
Owen Devine ◽  
Cara Mai ◽  
Heather C. Hamner ◽  
Jennita Reefhuis ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Fortification ◽  
Potential Impact ◽  
Corn Masa

scholarly journals Impact of Voluntary Folic Acid Fortification of Corn Masa Flour on RBC Folate Concentrations in the U.S. (NHANES 2011–2018)

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1325
Author(s):  
Arick Wang ◽  
Charles E. Rose ◽  
Yan Ping Qi ◽  
Jennifer L. Williams ◽  
Christine M. Pfeiffer ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Hispanic Women ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Folic Acid Fortification ◽  
Folate Concentration ◽  
Corn Masa ◽  
The U.S

Surveillance data have highlighted continued disparities in neural tube defects (NTDs) by race-ethnicity in the United States. Starting in 2016, the Food and Drug Administration (FDA) authorized voluntary folic acid fortification of corn masa flour to reduce the risk of neural tube defects (NTDs) among infants of Hispanic women of reproductive age. To assess the impact of voluntary corn masa fortification, cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 for Hispanic women of reproductive age with available red blood cell (RBC) folate concentrations were analyzed, with additional analyses conducted among Hispanic women whose sole source of folic acid intake was fortified foods (enriched cereal grain products (ECGP) only), excluding ready-to-eat cereals and supplements. RBC folate concentration (adjusted geometric mean) among Hispanic women of reproductive age did not differ between 2011–2016 and 2017–2018, though RBC folate concentration increased significantly among lesser acculturated Hispanic women consuming ECGP only. Concentrations of RBC folate for those born outside the U.S and residing in the U.S <15 years increased from 894 nmol/L (95% CI: 844–946) in 2011–2016 to 1018 nmol/L (95% CI: 982–1162; p < 0.001) in 2017–2018. Primarily Spanish-speaking Hispanic women of reproductive age who only consumed ECGP saw an increase from 941 nmol/L (95% CI: 895–990) in 2011–2016 to 1034 nmol/L (95% CI: 966–1107; p = 0.03) in 2017–2018. By subpopulation, we observed no significant changes in the proportion at risk of NTDs (<748 nmol/L) and no changes in the model-based estimated NTD rates following voluntary corn masa fortification. This analysis suggests that there is a remaining risk among Hispanics for folate sensitive NTDs, though continued monitoring of folate status in future NHANES data cycles will help inform the long-term efficacy of voluntary fortification of corn masa flour.

A Public Health Success Story: Folic Acid Fortification and Supplementation for Prevention of Neural Tube Defects

2004 ◽  
Author(s):  
Linda Longerich ◽  
Roy West ◽  
Ed Randell ◽  
Marian Crowley ◽  
Shiliang Liu ◽  
...  
Keyword(s):  
Public Health ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Success Story ◽  
Folic Acid Fortification

Reduction in Neural-Tube Defects after Folic Acid Fortification in Canada

2007 ◽  
Vol 357 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Philippe De Wals ◽  
Fassiatou Tairou ◽  
Margot I. Van Allen ◽  
Soo-Hong Uh ◽  
R. Brian Lowry ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Fortification
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