scholarly journals Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: Systematic review and meta-analysis

2013 ◽  
Vol 97 (7) ◽  
pp. 444-451 ◽  
Author(s):  
Jordana N. Peake ◽  
Andrew J. Copp ◽  
Jill Shawe
Keyword(s):  
Systematic Review ◽  
United Kingdom ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Ethnic Communities ◽  
The United Kingdom

Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 1-18
Author(s):  
Sara Soleimani-Jadidi ◽  
Bahare Meibodi ◽  
Atiyeh Javaheri ◽  
Razieh Sadat Tabatabaei ◽  
Amaneh Hadadan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Mthfr A1298c

scholarly journals Impact of folic acid fortification of flour on neural tube defects: a systematic review

2012 ◽  
Vol 16 (5) ◽  
pp. 901-911 ◽  
Author(s):  
Cecilia Castillo-Lancellotti ◽  
Josep A Tur ◽  
Ricardo Uauy
Keyword(s):  
Systematic Review ◽  
Folic Acid ◽  
Costa Rica ◽  
Latin American ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Fortification ◽  
Potential Association ◽  
The Usa ◽  
The Impact

AbstractObjectiveTo review the impact of folic acid fortification of flour on the prevalence of neural tube defects (NTD).DesignSystematic review of the literature on MEDLINE via PubMed, Scopus, OvidSP and LILACS (Latin American and Caribbean Health Sciences Literature) reporting the impact of folic acid fortification of flour on the prevalence of NTD in 2000–2011. Focusing on Santiago of Chile's birth defects registry (1999–2009) and the monitoring of flour fortification, we analysed the prevalence (NTD cases/10 000 births) pre and post flour fortification and the percentile distribution of folic acid content in flour (2005–2009). We explored the potential association between median folic acid in flour (mg/kg) and the prevalence of NTD.SettingChile, Argentina, Brazil, Canada, Costa Rica, Iran, Jordan, South Africa and the USA.SubjectsLive births and stillbirths.ResultsTwenty-seven studies that met inclusion criteria were evaluated. Costa Rica showed a significant reduction in NTD (∼60 %). Prevalence in Chile decreased from 18·6 to 7·3/10 000 births from 1999 to 2007 and showed a slight increase to 8·5 in 2008–2009, possibly due to changes in fortification limits. When we related the prevalence of NTD with levels of flour fortification, the lowest prevalence was observed at a folic acid level of 1·5 mg/kg.ConclusionsFortification of flour with folic acid has had a major impact on NTD in all countries where this has been reported. Chile showed a 55 % reduction in NTD prevalence between 1999 and 2009. There is a need to constantly monitor the levels of flour fortification to maximize benefits and prevent the potential risk of folic acid excess, moreover to be vigilant for any new adverse effects associated with excess.

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