Emerging data on the use of anti-tumor necrosis factor-alpha medications in pregnancy

2012 ◽  
Vol 94 (8) ◽  
pp. 607-611 ◽  
Author(s):  
Christina D. Chambers ◽  
Diana L. Johnson
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
In Pregnancy

scholarly journals Interleukin 10 and Tumor Necrosis Factor-Alpha in Pregnancy: Aspects of Interest in Clinical Obstetrics

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Jusciele Brogin Moreli ◽  
Ana Maria Cirino Ruocco ◽  
Joice Monaliza Vernini ◽  
Marilza Vieira Cunha Rudge ◽  
Iracema Mattos Paranhos Calderon
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Fetal Loss ◽  
Interleukin 10 ◽  
Necrosis Factor Alpha ◽  
Study Results ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
In Pregnancy

The purpose of this study was to review the literature regarding the action of the cytokines interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnancy and to emphasize the factors that are of interest to clinical obstetrics. The literature highlights several actions of IL-10 and TNF-α during pregnancy. The actions of these cytokines seem to be antagonistic and dependent on the balance between them, which is orchestrated by the specific immunosuppressive action of IL-10. TNF-α has a characteristic inflammatory action, and it is an additional diabetogenic factor in pregnancy. The loss of the control of the production of these cytokines, with increase of TNF-α, is related to the risk for developing obstetric complications, particularly recurrent fetal loss, gestational diabetes mellitus, hypertensive syndromes, and fetal growth restriction. However, study results are controversial and are not clearly defined. These issues are attributed to the heterogeneity of the studies, particularly regarding their sample sizes and sources, the evaluation methods, and the multiplicity of factors and conditions that influence cytokine production. These questions are fundamental and should be addressed in future investigations to obtain more consistent results that can be applied to obstetric practice.

The crosstalk between Nodal and Tumor Necrosis factor alpha during luteolysis establishment in the mare

2016 ◽  
Author(s):  
Antonio Galvao ◽  
Joanna Staszkiewicz ◽  
Karolina Thomas ◽  
Maria Rebordao ◽  
Dariusz Skarzynski ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Pancreatic beta-cell-selective production of tumor necrosis factor-alpha induced by interleukin-1

Diabetes ◽  
1993 ◽  
Vol 42 (7) ◽  
pp. 1026-1031 ◽  
Author(s):  
K. Yamada ◽  
N. Takane ◽  
S. Otabe ◽  
C. Inada ◽  
M. Inoue ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Beta Cell ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Interleukin 1 ◽  
Pancreatic Beta Cell ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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