scholarly journals NicotinamideN-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida

2008 ◽  
Vol 82 (10) ◽  
pp. 670-675 ◽  
Author(s):  
Wei Lu ◽  
Huiping Zhu ◽  
Shu Wen ◽  
Wei Yang ◽  
Gary M. Shaw ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Gene Polymorphisms ◽  
Methyl Transferase

scholarly journals THE ASSOCIATION OF CATECHOL-O-METHYL-TRANSFERASE AND INTERLEUKIN 6 GENE POLYMORPHISMS WITH POSTTRAUMATIC STRESS DISORDER

2019 ◽  
Vol 31 (2) ◽  
pp. 241-248 ◽  
Author(s):  
Valdete Haxhibeqiri ◽  
◽  
Shpend Haxhibeqiri ◽  
Valdete Topciu-Shufta ◽  
Ferid Agani ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Stress Disorder ◽  
Methyl Transferase

Different Prevalence of Drug Metabolism Gene Polymorphisms (GSTP and GSTT) in FA Patients Compared to a Normal Population.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 106-106 ◽  
Author(s):  
Moema Nene Santos ◽  
Vanderson Rocha ◽  
Dalila Zanette ◽  
Raphael Porcher ◽  
Irina Ionescu ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Methylenetetrahydrofolate Reductase ◽  
Normal Population ◽  
Conditioning Regimen ◽  
Mthfr C677t ◽  
Chemotherapeutic Agents ◽  
Methyl Transferase ◽  
Hematopoietic Stem ◽  
Increased Risk ◽  
Normal Controls

Abstract Fanconi Anemia patients have an increased toxicity of drugs used in conditioning regimen (CT) for hematopoietic stem cell transplantation (HSCT), due to defective DNA repair processes. This observation has led to diminish the doses of drugs (such as cyclophosphamide and busulphan) and irradiation in the preparative regimen. We and others have reported that genetic polymorphisms, which interfere with metabolisms of drugs used in CT, are associated with toxicities after HSCT. In order to test the hypothesis that probably Fanconi patients have a difference in prevalence of pharmacogene polymorphisms, we have compared the samples of 49 Fanconi patients (median age of 6,2 years) with 107 samples of normal population of the same ethnic group. Polymerase chain reaction (PCR) and restriction-digestion protocols were used to identify most of the polymorphisms. We have selected pharmacogenes knonwn to interfere with the metabolisms of drugs used in the CT or GVHD prophylaxis. The following gene polymorphisms were analyzed: P450 cytochrome family [CYP2B6*2(C64T), *4(A785G), *5(C1459T), *6(G516T)]; glutathion-S-Transferases [GSTM1 (null), GSTT1(null), GSTP1(G313A)], Thiopurine-S-methyl transferase [TPMT *3B (G460A) and *3C (G238C)], Multiresistance-drug [MDR1 (C3435T)], Methylenetetrahydrofolate reductase [MTHFR (C677T, A1298C)], Vitamin D receptor [VDR (ApaI, TaqI and BsmI)]. All gene polymorphisms studied were found in the same frequency in FA as in normal controls, except polymorphisms of GSTP and GSTT. In fact, FA patients had a higher frequency of mutant alleles (AG or GG) of GSTP (86%; n=42) compared to 51% (n=55) in normal controls (p<0.001). GSTP polymorphisms are associated with reduced ability to detoxify chemotherapeutic agents thereby increasing the effective dose of the drug within the cell. It has also been associated with increased risk of breast, prostate, bladder and testicular cancer. We have also observed a decreased frequency of GSTT wild type (null; 8%, n=4) in FA patients compared to normal controls (25%, n=27) (p=0.01). In conclusion, this study shows that prevalence of GSTP and GSTT gene polymorphisms in FA is different from the normal population.

scholarly journals PhosphatidylethanolamineN-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida

2006 ◽  
Vol 140A (7) ◽  
pp. 785-789 ◽  
Author(s):  
Jing Zhang ◽  
Huiping Zhu ◽  
Wei Yang ◽  
Gary M. Shaw ◽  
Edward J. Lammer ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Gene Polymorphisms

Are Catechol-O-Methyl Transferase (COMT) Gene Polymorphisms Associated With Visceral Pain? – A Study in a Large Cohort of Chronic Pancreatitis (CP) Patients

2011 ◽  
Vol 140 (5) ◽  
pp. S-857
Author(s):  
Thiruvengadam Muniraj ◽  
Dhiraj Yadav ◽  
Jessica LaRusch ◽  
Michelle A. Anderson ◽  
John M. Lyons ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Gene Polymorphisms ◽  
Visceral Pain ◽  
Large Cohort ◽  
Comt Gene ◽  
Methyl Transferase

P.3.c.063 Effect of 5-HT1a and catechol-O-methyl-transferase gene polymorphisms on negative symptom response to clozapine

2009 ◽  
Vol 19 ◽  
pp. S546-S547
Author(s):  
S. Porcelli ◽  
M. Bosia ◽  
F. Cocchi ◽  
E. Marino ◽  
E. Smeraldi ◽  
...  
Keyword(s):  
Negative Symptom ◽  
Gene Polymorphisms ◽  
Methyl Transferase ◽  
Transferase Gene ◽  
Symptom Response

scholarly journals DNA Methyl Transferase (DNMT) Gene Polymorphisms Could Be a Primary Event in Epigenetic Susceptibility to Schizophrenia

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e98182 ◽  
Author(s):  
Koramannil Radha Saradalekshmi ◽  
Nanoth Vellichiramal Neetha ◽  
Sanish Sathyan ◽  
Indu V. Nair ◽  
Chandrasekharan M. Nair ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Primary Event ◽  
Methyl Transferase
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