Teratogenic effects of retinoic acid are modulated in mice lacking expression of epidermal growth factor and transforming growth factor-?

2005 ◽  
Vol 73 (4) ◽  
pp. 204-217 ◽  
Author(s):  
Barbara D. Abbott ◽  
Deborah S. Best ◽  
Michael G. Narotsky
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transforming Growth Factor ◽  
Teratogenic Effects ◽  
Epidermal Growth

scholarly journals Bradykinin-induced growth inhibition of normal rat kidney (NRK) cells is paralleled by a decrease in epidermal-growth-factor receptor expression

1994 ◽  
Vol 298 (2) ◽  
pp. 335-340 ◽  
Author(s):  
E J J Van Zoelen ◽  
P H J Peters ◽  
G B Afink ◽  
S Van Genesen ◽  
A D G De Roos ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Egf Receptor ◽  
Transforming Growth Factor ◽  
Rat Kidney ◽  
Receptor Expression ◽  
Binding Studies ◽  
Normal Rat ◽  
Epidermal Growth

Normal rat kidney fibroblasts, grown to density arrest in the presence of epidermal growth factor (EGF), can be induced to undergo phenotypic transformation by treatment with transforming growth factor beta or retinoic acid. Here we show that bradykinin blocks this growth-stimulus-induced loss of density-dependent growth arrest by a specific receptor-mediated mechanism. The effects of bradykinin are specific, and are not mimicked by other phosphoinositide-mobilizing agents such as prostaglandin F2 alpha. Northern-blot analysis and receptor-binding studies demonstrate that bradykinin also inhibits the retinoic acid-induced increase in EGF receptor levels in these cells. These studies provide additional evidence that EGF receptor levels modulate EGF-induced expression of the transformed phenotype in these cells.

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