Cyclophosphamide, methotrexate, and cytarabine embropathy: Is apoptosis the common pathway?

2003 ◽  
Vol 67 (6) ◽  
pp. 403-408 ◽  
Author(s):  
Keith K. Vaux ◽  
Nathanial C.O. Kahole ◽  
Kenneth Lyons Jones
Keyword(s):  
Common Pathway ◽  
The Common

LED Street Lighting: A Looking Ahead Perspective

Green ◽  
2015 ◽  
Vol 5 (1-6) ◽  
Author(s):  
Rosaria Ciriminna ◽  
Lorenzo Albanese ◽  
Francesco Meneguzzo ◽  
Mario Pagliaro
Keyword(s):  
Carbon Dioxide Emissions ◽  
Common Pathway ◽  
Street Lighting ◽  
Light Emitting ◽  
Global Impact ◽  
Remote Areas ◽  
Quality Principles ◽  
The Common ◽  
Reduce Carbon Dioxide

AbstractProvided that LED street lighting is guided by quality principles, outdoor illumination using light-emitting diodes will have a significant global impact helping to reduce carbon dioxide emissions, save relevant amounts of electricity and enhance the quality of life in cities as well as in remote areas. This study summarizes recent findings providing guidelines for further progress in this crucially important technology on the common pathway to sustainable development.

Tu-P7:233 Is inflammation the common pathway towards aortic sclerosis and atherosclerosis?

2006 ◽  
Vol 7 (3) ◽  
pp. 236
Author(s):  
M. Rugina ◽  
R. Jurcut ◽  
A. Salageanu ◽  
C. Jurcut ◽  
I. Caras ◽  
...  
Keyword(s):  
Common Pathway ◽  
Aortic Sclerosis ◽  
The Common

Inflorescence and floral ontogeny in Jasminum fruticans (Oleaceae)

2011 ◽  
Vol 59 (5) ◽  
pp. 498 ◽  
Author(s):  
Mohammad Reza Dadpour ◽  
Somayeh Naghiloo ◽  
Somayeh Faridi Neycharan
Keyword(s):  
Light Microscopy ◽  
Distal Portion ◽  
Common Pathway ◽  
Floral Ontogeny ◽  
Floral Organs ◽  
The Common

The inflorescence and floral ontogeny of the oleaceous tropical bush, Jasminum fruticans L. were studied using epi-illumination light microscopy and compared with other Oleaceae. The flowers are arranged in a thyrsoid inflorescence with a determinate pattern of development. Deviations from the common pathway of floral ontogeny in Oleaceae observed in J. fruticans are characterised by pentamery in calyx and corolla, diagonal position of sepals, some deviation from acropetal and simultaneous initiation of floral organs. Sepals are helically initiated, beginning with the abaxial sepal. Formation of petal lobes from the ring meristem also is not simultaneous with the initiation of three petals before the others. Concurrently with the formation of corolla ring, two stamens are initiated sequentially. Two median carpels are the last organs to be initiated. Unusual features of organ enlargement include the quincuncial-imbricate aestivation of the corolla and formation of trichomes on the distal portion of petals and stamens.

scholarly journals Alterations in the Common Pathway of Coagulation During Weight Loss Induced by Gastric Bypass in Severely Obese Patients

Obesity ◽  
2012 ◽  
Vol 20 (5) ◽  
pp. 1048-1056 ◽  
Author(s):  
Eva Pardina ◽  
Roser Ferrer ◽  
Joaquín Rivero ◽  
Juan A. Baena-Fustegueras ◽  
Albert Lecube ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Obese Patients ◽  
Common Pathway ◽  
Severely Obese ◽  
The Common

Natural IgM Against Oxidation-Specific Epitopes Inhibit Microvesicle-Driven Coagulation

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 2562-2562
Author(s):  
Georg Obermayer ◽  
Taras Afonyushkin ◽  
Florian Puhm ◽  
Michael Schwameis ◽  
Bernd Jilma ◽  
...  
Keyword(s):  
Coagulation Cascade ◽  
Factor Vii ◽  
Factor Xii ◽  
Common Pathway ◽  
Thrombotic Risk ◽  
Igm Antibodies ◽  
Igm Antibody ◽  
The Common ◽  
Natural Igm ◽  
Maximum Clot Firmness

Abstract Increasing evidence demonstrates an important role for immune functions in coagulation and thrombosis, and both microbial and sterile triggers have been implicated in these responses. Oxidation-specific epitopes (OSE) are products of lipid peroxidation that are present on oxidized low-density lipoproteins and dying cells, and represent important sterile triggers of inflammation in cardiovascular diseases. We have previously shown that a large part of naturally occurring IgM antibodies have specificity for OSEs and that 50% of circulating procoagulant microvesicles (MV) carry OSEs, such as malondialdehyde-adducts (MDA), on their surface. Because OSE-specific natural IgM bind MVs and increased levels of circulating MVs have been implicated in an increased thrombotic risk, we studied the capacity of these antibodies in directly modulating the procoagulant potential of MVs in vitro and in vivo. We first showed that increasing concentrations of three different monoclonal IgM antibodies with specificity for MDA (LR04, NA17, E014) significantly delayed MV-induced fibrin formation in plasma, while an MDA-specific IgG antibody or F(ab')2 fragments of LR04 had no effect. Moreover, peak thrombin generation of normal, factor VII- or factor XII- deficient microvesicle poor plasma (MVPP) substituted with tissue factor positive MVs was significantly reduced in the presence of LR04 but not a control IgM antibody, indicating that it exerts its effect on the common pathway of the coagulation cascade. A similar anticoagulatory effect of LR04 was observed in freshly drawn whole blood analyzed by rotational thrombelastometry. Addition of LR04, compared to a control IgM antibody, increased clotting time, clot formation time, and the time to reach maximum clot firmness, and decreased maximum clot firmness. Finally, in a murine pulmonary embolism model, we could show that 30-minute survival of mice that received intravenous injections of epinephrine together with pro-coagulant MVs derived from the pancreatic cancer cell line HPAFII was significantly increased in mice co-injected with LR04 compared to controls. Our study identifies an inhibitory role of MDA-specific IgM antibodies in MV-induced coagulation. These effects are exerted on the common pathway of the coagulation cascade and require the intact structure of IgM antibodies. The findings may offer novel diagnostic and therapeutic approaches in the prevention and treatment of thrombosis. Disclosures No relevant conflicts of interest to declare.

scholarly journals INTERFERENCE OF Bothrops jararacussu AND Bothrops cotiara VENOMS UPON BLOOD COAGULATION PATHWAYS

2008 ◽  
Vol 30 (70/72) ◽  
Author(s):  
Fabiane Barchiki ◽  
Luiz Fernando Pereira ◽  
Selene Lobo Elifio-Esposito
Keyword(s):  
Human Plasma ◽  
Coagulation Cascade ◽  
Snake Venoms ◽  
Common Pathway ◽  
Coagulation Time ◽  
Bovine Thrombin ◽  
Bothrops Jararacussu ◽  
Interaction Processes ◽  
The Common ◽  
Specific Reagent

Hemostasis includes mechanisms for the hemodynamic balance and integrity of the cardiovascular system. Overflow of blood provoke as an answer the activation of coagulation cascade which leads to a clot of fibrin. Snake venoms affect different interaction processes within the haemostatic system. Bothrops jararacussu ando B. cotiara venoms were compared. Coagulation time (CT) were determined by the addition of venom samples to human plasma at 37OC. Minimum coagulant dose (MCD) was measured by the incubation of human plasma to venom sample in decreasing concentrations in two-fold serial dilutions (from 50 μg/ml). For thrombin (TT) and prothrombin time (PT) 100 μl of citrated plasma were incubated at 37ºC for 60 sec followed by the addition of 200 μl specific reagent (bovine thrombin and thromboplastin, respectively). B. jararacussu venom presented TC of 29.4 sec and DMC of 250 mg/l. For B. cotiara venom TC was 30.2 sec and DMC 125 mg/l. Results suggested that both snakes venoms acted upon the common pathway.

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