Risk factors for neural tube defects: Associations between uncoupling protein 2 polymorphisms and spina bifida

2003 ◽  
Vol 67 (3) ◽  
pp. 158-161 ◽  
Author(s):  
Kelly A. Volcik ◽  
Gary M. Shaw ◽  
Huiping Zhu ◽  
Edward J. Lammer ◽  
Richard H. Finnell
Keyword(s):  
Risk Factors ◽  
Spina Bifida ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2

Prevalence of open neural tube defects and risk factors related to isolated anencephaly and spina bifida in live births from the “Dr. Juan I. Menchaca” Civil Hospital of Guadalajara (Jalisco, Mexico)

2020 ◽  
Author(s):  
Jorge Román Corona‐Rivera ◽  
Sandra Olvera‐Molina ◽  
J. Jesús Pérez‐Molina ◽  
Cristian Irela Aranda‐Sánchez ◽  
Lucina Bobadilla‐Morales ◽  
...  
Keyword(s):  
Risk Factors ◽  
Spina Bifida ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Civil Hospital ◽  
Live Births

Detection of spina bifida in the first trimester of gestation in association with triploidy

2017 ◽  
Author(s):  
K.K. Otaryan , C.G. Gagaev
Keyword(s):  
Spina Bifida ◽  
Early Detection ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Diagnostic Tools ◽  
Prenatal Detection ◽  
Post Abortion

The case of prenatal detection of spina bifida at 12+3 weeks of gestation is described. Termination of pregnancy was performed at 13+3 weeks. Post-abortion karyotyping revealed triploidy (69XXX). Diagnostic tools for early detection of neural tube defects in the 1st trimester of gestation and subsequent appropriate management of pregnancy are discussed.

scholarly journals Mengenal Spina Bifida dan Pencegahannya

2021 ◽  
Vol 1 (12) ◽  
pp. 896-903
Author(s):  
Genta Faesal Atsani ◽  
Zanetha Mauly Ilawanda ◽  
Ilma Fahira Basyir
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Abnormality ◽  
Congenital Abnormalities ◽  
Folic Acid Supplementation ◽  
Online Portal ◽  
The Brain ◽  
Developing Spinal Cord

Neural tube defects (NTD) are one of the birth defects or congenital abnormalities that occur in the brain and spine, and commonly find in newborns worldwide. Anencephaly and spina bifida are the two prevalent forms of NTD. The incidence of spina bifida happen on average 1 in 1000 cases of birth worldwide and there are 140,000 cases per year worldwide. Source searches were carried out on the online portal of journal publications as many as 20 sources from MedScape, Google Scholar and the Nation Center for Biotechnology Information / NCBI with the keywords “Neural tube defects (NTD), prevention, and spina bifida”. Spina bifida is a congenital abnormality that occurs in the womb due to a failure of closing process the neural tube during the first few weeks of embryonic development which causes the spine not completely close around the developing spinal cord nerves. NTD can ensue multifactorial conditions such as genetic, environmental, and folate deficiency. The use of folic acid supplementation starting at least 3 months before pregnancy, those are 400 mcg (0.4 mg) per day and 800 mcg per day during pregnancy can reduce the risk of developing neural tube defects such as spina bifida. Generally, spina bifida is undertaking by surgery and the regulation of patients comorbid. Public can find out prevention to avoid or reduce the risk of spina bifida so that the incidence of spina bifida can decrease along with the increasing awareness of the community regarding this disease.

Association of maternal risk factors with the recent rise of neural tube defects in Canada

2019 ◽  
Vol 33 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Shiliang Liu ◽  
Jane Evans ◽  
Amanda J. MacFarlane ◽  
Cande V. Ananth ◽  
Julian Little ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Maternal Risk Factors ◽  
Maternal Risk

Concanavalin A binding of alpha-fetoprotein in amniotic fluid as an aid in the diagnosis of neural tube defects.

1981 ◽  
Vol 27 (10) ◽  
pp. 1658-1660 ◽  
Author(s):  
P K Buamah ◽  
P Taylor ◽  
A M Ward
Keyword(s):  
Spina Bifida ◽  
Amniotic Fluid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Concanavalin A ◽  
Gestational Age ◽  
Alpha Fetoprotein ◽  
Normal Outcome ◽  
Fetal Malformations ◽  
Open Spina Bifida

Abstract Concanavalin A nonreactive alpha-fetoprotein was determined in samples of amniotic fluid from 16 abnormal pregnancies complicated by anencephaly (7), open spina bifida (6), intra-uterine death (1), anencephaly with exomphalos (1), or open spina bifida with exomphalos (1), and in amniotic fluid from 50 normal pregnancies with gestational age between 13 and 24 weeks. In all 16 cases with fetal malformations, the proportion of nonreactive alpha-fetoprotein was significantly decreased (median 5.3%) as compared with amniotic fluid from pregnancies with a normal outcome (median 39.7%). The results confirm that this measurement is useful in the diagnosis of neural tube defects, especially when the concentration of alpha-fetoprotein in amniotic fluid is normal or only slightly above normal and gestational age is uncertain.

scholarly journals Evaluation of proton-coupled folate transporter (SLC46A1 ) polymorphisms as risk factors for neural tube defects and oral clefts

2016 ◽  
Vol 170 (4) ◽  
pp. 1007-1016 ◽  
Author(s):  
Julia E. VanderMeer ◽  
Tonia C. Carter ◽  
Faith Pangilinan ◽  
Adam Mitchell ◽  
Emma Kurnat-Thoma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Oral Clefts
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