scholarly journals Prevention and awareness of birth defects across the lifespan using examples from congenital heart defects and spina bifida

2021 ◽  
Author(s):  
Sherry L. Farr ◽  
Catharine Riley ◽  
Alissa R. Van Zutphen ◽  
Timothy J. Brei ◽  
Vinita Oberoi Leedom ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects

Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011

2021 ◽  
Author(s):  
Elijah H. Bolin ◽  
Yevgeniya Gokun ◽  
Paul A. Romitti ◽  
Sarah C. Tinker ◽  
April D. Summers ◽  
...  
Keyword(s):  
Birth Defects ◽  
Congenital Heart Defects ◽  
Maternal Smoking ◽  
Congenital Heart ◽  
Heart Defects ◽  
Prevention Study

Evaluation of theCited2 gene and risk for spina bifida and congenital heart defects

2004 ◽  
Vol 126A (3) ◽  
pp. 324-325 ◽  
Author(s):  
Kelly A. Volcik ◽  
Huiping Zhu ◽  
Richard H. Finnell ◽  
Gary M. Shaw ◽  
Mark Canfield ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects

Abstract 15517: Receipt of Special Education Services Among Children with Congenital Heart Defects in Atlanta, Georgia

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Tiffany Colarusso ◽  
Autry Andrew ◽  
Hilda Razzaghi ◽  
Coleen Boyle ◽  
William Mahle ◽  
...  
Keyword(s):  
Special Education ◽  
Birth Defects ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Population Based ◽  
Surveillance Program ◽  
Special Education Services ◽  
Education Services ◽  
Prevalence Ratios

BACKGROUND: Population-based information on special education service needs among children with congenital heart defects (CHDs) is limited. We investigated the prevalence of receipt of special education services among children with CHDs. METHODS: Children born from 1982-2004 in metropolitan Atlanta with CHDs (n=3,744) were identified from a population-based birth defect surveillance program, and contemporaneous children born without major birth defects (n=860,715) were identified from birth certificates. Cohorts were linked to special education files for 1992-2012 school years to identify receipt of special education services. Children with CHDs and non-cardiac defects or genetic syndromes were excluded; children with isolated CHDs were classified by presence or absence of critical CHDs (i.e., defects needing intervention in the first year of life). We evaluated prevalence of special education services and calculated prevalence ratios (PRs) using children without birth defects as reference. RESULTS: Children with CHDs were 50% more likely than those without birth defects to use special education services (PR 1.5; 95% Confidence interval 1.4-1.7). Similar to children without birth defects, the most common eligibility among children with CHDs was speech/language impairment. Compared to children without birth defects, the prevalence of several special education eligibilities were significantly higher among children with all CHDs: any intellectual disability (PR 3.8), sensory impairment (PR 3.0), other health impairment (PR 2.8), significant developmental delay (PR 1.9), orthopedic impairment (PR 1.9), and specific learning disability (PR 1.4). For most special education eligibilities, there was no significant variation in the elevated prevalence ratios by presence or absence of critical CHDs. CONCLUSIONS: Children with many types of CHDs received special education services more often than children without birth defects. These findings highlight important resource needs for children with CHDs. Furthermore, they suggest that recommendations to perform developmental screening only on children with select CHDs may miss or delay identification of children with other CHDs, who may also need special education services.

The clinic pattern of pulmonary artery vasoconstriction in children (morbus coelius)

1927 ◽  
Vol 23 (10) ◽  
pp. 1041-1045
Author(s):  
B. M. Deich
Keyword(s):  
Pulmonary Artery ◽  
Birth Defects ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Pulmonary Artery Stenosis ◽  
Septal Defects ◽  
Nosological Entity ◽  
Simultaneous Existence ◽  
Large Vessels

"Blue disease" is not a separate nosological entity, but represents a certain syndrome accompanying congenital heart defects. Despite the fact that this disease has long been known, nevertheless, its pathogenesis has not yet been definitively established. The former authors explained various individual forms of cardiac birth defects by this syndrome, but now it has been established that "blue disease" is a collective concept and occurs, according to Barye, in septal defects and anomalies of large vessels, and according to Fallop, in simultaneous existence of pulmonary artery stenosis and non-cavitary septum as well as in non-cavitary ductus botalus.

scholarly journals Maternal occupational pesticide exposure and risk of congenital heart defects in the national birth defects prevention study

2015 ◽  
Vol 103 (10) ◽  
pp. 823-833 ◽  
Author(s):  
Carissa M. Rocheleau ◽  
Stephen J. Bertke ◽  
Christina C. Lawson ◽  
Paul A. Romitti ◽  
Wayne T. Sanderson ◽  
...  
Keyword(s):  
Birth Defects ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Pesticide Exposure ◽  
Heart Defects ◽  
Prevention Study

scholarly journals Сongenital diseases of the heart among newborn children: genetic aspects

2019 ◽  
Keyword(s):  
Pregnant Women ◽  
Birth Defects ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Chromosomal Abnormalities ◽  
Heart Defects ◽  
Circulatory System ◽  
Reproductive Age ◽  
Multiple Birth ◽  
Perinatal Pathology

Congenital heart defects are a heterogeneous group of diseases that occur as isolation or a part of multiple birth defects, gene disorders or chromosomal abnormalities. Chromosomal abnormalities and its underlying syndromes are the cause of 6 to 36% of cases of congenital heart defects. Monogenic etiology is proven in about 8% of cases, and the main group - about 90% of the congenital heart defects is the result of an unfavorable combination of genetic predisposition and external factors. The causes of early neonatal infant mortality are dominated by incompatible birth defects: almost 26% of perinatal and neonatal deaths are associated with congenital child pathology. Heart defects compose about 30% of all birth defects. They rank first place among the diseases that lead to perinatal mortality and early disability. World statistics show that the incidence of birth defects in the world is 9 per 1000 newborns, in Europe - 8/1000, which is 4 times more frequent than neural tube defects and 6 times higher than chromosomal abnormalities. In Ukraine, about 5,000 children with congenital heart defects are born each year, and the total number of those children on dispensary records reaches more than 45,000. Knowledge about the prevalence of birth defects in the region is needed to develop new information markers of the risk of congenital pathology of the circulatory system for women of reproductive age. Data on the incidence of congenital heart defects of fetuses and newborns in the region will allow the creation of a database for follow-up studies, which will facilitate the timely identification of pregnant women at risk. This will improve the prognosis of pregnancy, reduce the level of perinatal pathology, which will have a significant medical and social effect. The data obtained will allow to create preconditions for improvement of approaches to the definition of risk groups of perinatal pathology, perfection of specialized care for pregnant women with risk of congenital heart defects of the fetus.

scholarly journals Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans

Scientifica ◽  
2017 ◽  
Vol 2017 ◽  
pp. 1-29 ◽  
Author(s):  
Siti W. Mohd-Zin ◽  
Ahmed I. Marwan ◽  
Mohamad K. Abou Chaar ◽  
Azlina Ahmad-Annuar ◽  
Noraishah M. Abdul-Aziz
Keyword(s):  
Central Nervous System ◽  
Animal Model ◽  
Spina Bifida ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Heart ◽  
Review Paper ◽  
Heart Defects ◽  
Central Nervous System Malformation

Spina bifida is among the phenotypes of the larger condition known as neural tube defects (NTDs). It is the most common central nervous system malformation compatible with life and the second leading cause of birth defects after congenital heart defects. In this review paper, we define spina bifida and discuss the phenotypes seen in humans as described by both surgeons and embryologists in order to compare and ultimately contrast it to the leading animal model, the mouse. Our understanding of spina bifida is currently limited to the observations we make in mouse models, which reflect complete or targeted knockouts of genes, which perturb the whole gene(s) without taking into account the issue of haploinsufficiency, which is most prominent in the human spina bifida condition. We thus conclude that the need to study spina bifida in all its forms, both aperta and occulta, is more indicative of the spina bifida in surviving humans and that the measure of deterioration arising from caudal neural tube defects, more commonly known as spina bifida, must be determined by the level of the lesion both in mouse and in man.

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