Post‐traumatic stress disorder, anxiety, and depression among adults with congenital heart defects

2021 ◽  
Author(s):  
Regina M. Simeone ◽  
Karrie F. Downing ◽  
William V. Bobo ◽  
Scott D. Grosse ◽  
Amber D. Khanna ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Congenital Heart ◽  
Stress Disorder ◽  
Heart Defects ◽  
Anxiety And Depression ◽  
Post Traumatic Stress ◽  
Post Traumatic

Silymarin Prevents Memory Impairments, Anxiety, and Depressive-Like Symptoms in a Rat Model of Post-Traumatic Stress Disorder

Planta Medica ◽  
2018 ◽  
Vol 85 (01) ◽  
pp. 32-40 ◽  
Author(s):  
Tamam El-Elimat ◽  
Karem Alzoubi ◽  
Mahmoud AbuAlSamen ◽  
Zeinab Al Subeh ◽  
Tyler Graf ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Anxiety And Depression ◽  
Long Term Memory ◽  
Post Traumatic Stress ◽  
Term Memory ◽  
Memory Impairments ◽  
Post Traumatic

AbstractPost-traumatic stress disorder (PTSD) is a debilitating psychopathological disease that is triggered by exposure to traumatic events. It is usually associated with substantial comorbidities, such as cognitive impairment, anxiety, and depression. Silymarin has been recently reported to exert neuroprotective activities against neurodegenerative diseases such as Alzheimerʼs and Parkinsonʼs diseases. Herein, the beneficial effects of silymarin in ameliorating PTSD-like symptoms such as memory impairments, anxiety, and depression were evaluated using a single-prolonged stress (SPS) rat model of PTSD. Male Wistar rats were randomly assigned into four groups: control, silymarin, SPS, or SPS + silymarin. Rats were administrated silymarin, 100 mg/kg i. p. for 4 wk. Rats in all groups were tested for short- and long-term memory in the radial arm water maze (RAWM), for anxiety-like behaviors using the open field test (OFT) and elevated plus maze (EPM) test, and for depression-like symptoms using the tail suspension test (TST). Conventional analyses of the RAWM, EPM, OFT, and TST were conducted using analysis of variance. Additionally, the anxiety-related behavior parameters of the EPM and OFT were entered to principal component analysis. Regression scores based on the first two extracted components, which accounted for 61% of the variance, were indicative of the anxiolytic activity of silymarin. Collectively, the results suggest that silymarin treatment prevents SPS-induced long-term memory impairments, anxiety, and depressive-like symptoms in rat models.

scholarly journals A Comparative Study of Post-traumatic Stress Disorder, Anxiety, Depression and Change in Sexual Functioning of Patients with Facial Injuries and Patients with Extremity Injuries

2015 ◽  
Vol 16 (11) ◽  
pp. 884-892 ◽  
Author(s):  
Dilip Kumar ◽  
HP Raghuveer ◽  
NT Prashanth ◽  
ES Shobha ◽  
Vinod Rangan ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Sexual Functioning ◽  
Stress Disorder ◽  
Anxiety And Depression ◽  
Post Traumatic Stress ◽  
Facial Injuries ◽  
Post Traumatic ◽  
Extremity Injuries ◽  
Anxiety Depression

ABSTRACT Background This study was performed to identify and compare the presence of and the levels of post-traumatic stress disorder (PTSD), anxiety, depression and if any change in sexual functioning is present in patients with disfiguring facial injuries, nondisfiguring facial injuries and visible extremity injuries. Materials and methods A total of 378 patients from multi modal trauma centers in Bengaluru city were included for the study. A total of 153 patients were those who had disfiguring facial injuries, 111 patients with nondisfiguring facial injuries and 114 patients had sustained a visible extremity injury that was not covered by clothing (disfigurement /scarring). The assessments were carried out at three time intervals (the date of discharge, 1 month postoperatively and 6 months postoperatively) of the follow-up. The impact of events scale (IES), the hospital anxiety and depression scale (HADS) and changes in sexual functioning questionnaire (CSFQ) were used. Results Statistically significant higher means of IES, HADS (both for anxiety and depression) were present in patients with disfiguring facial injuries compared to patients with nondisfiguring facial injuries and visible extremity injuries and this was present at all three study intervals (date of discharge, 1st postoperative month and 6th postoperative month). There was a statistically significant change in the means of CSFQ scores of visible extremity injuries compared to other groups at the date of discharge bordering on sexual dysfunction, there was a raise in CSFQ scores among all three groups at the 1st postoperative month and the 6th postoperative month which was above the dysfunction cut-off. Conclusion The results of this study led to the conclusion that in comparison with patients who had sustained disfiguring facial injuries, nondisfiguring facial injuries and visible extremity/ orthopedic injuries, the mean IES scores, HADS scores for both anxiety and depression of the facial disfiguring injury patients was higher at all three study intervals (date of discharge, 1st postoperative month and 6 months postoperatively), indicating higher PTSD levels, anxiety and depression in patients with disfiguring facial injuries, CSFQ scores were above the cutoff suggested at the 1st month and 6th month postoperative indicating no sexual dysfunction in all the three groups. How to cite this article Prashanth NT, Raghuveer HP, Kumar D, Shobha ES, Rangan V, Rao TSS. A Comparative Study of Posttraumatic Stress Disorder, Anxiety, Depression and Change in Sexual Functioning of Patients with Facial Injuries and Patients with Extremity Injuries. J Contemp Dent Pract 2015;16(11): 884-892.

scholarly journals Medically Related Post-traumatic Stress in Children and Adolescents with Congenital Heart Defects

2017 ◽  
Vol 5 ◽  
Author(s):  
Maya G. Meentken ◽  
Ingrid M. van Beynum ◽  
Jeroen S. Legerstee ◽  
Willem A. Helbing ◽  
Elisabeth M. W. J. Utens
Keyword(s):  
Children And Adolescents ◽  
Congenital Heart Defects ◽  
Traumatic Stress ◽  
Congenital Heart ◽  
Heart Defects ◽  
Post Traumatic Stress ◽  
Post Traumatic
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