Environmental exposures during pregnancy: Mechanistic effects on immunity

2019 ◽  
Vol 111 (4) ◽  
pp. 178-196 ◽  
Author(s):  
Kristal A. Rychlik ◽  
Fenna C. M. Sillé
Keyword(s):  
Environmental Exposures ◽  
Exposures During Pregnancy

Environmental exposures during pregnancy: US National Children's Study formative research investigation

2014 ◽  
Vol 43 ◽  
pp. 79
Author(s):  
R.K. Miller ◽  
T.H. Darrah ◽  
A. Friedman ◽  
A. Li ◽  
C.J. Stodgell ◽  
...  
Keyword(s):  
Environmental Exposures ◽  
Formative Research ◽  
Exposures During Pregnancy

scholarly journals Bias due to Selection on Live Births in Studies of Environmental Exposures during Pregnancy: A Simulation Study

2021 ◽  
Vol 129 (4) ◽  
Author(s):  
Michael Leung ◽  
Marianthi-Anna Kioumourtzoglou ◽  
Raanan Raz ◽  
Marc G. Weisskopf
Keyword(s):  
Simulation Study ◽  
Environmental Exposures ◽  
Live Births ◽  
Exposures During Pregnancy

Infant Acute Leukemia and Environmental Exposures During Pregnancy

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S168
Author(s):  
M S. Pombo de Oliveira ◽  
S Koifman
Keyword(s):  
Acute Leukemia ◽  
Environmental Exposures ◽  
Exposures During Pregnancy

Urban-Related Environmental Exposures during Pregnancy and Placental Development and Preeclampsia: a Review

2020 ◽  
Vol 22 (10) ◽  
Author(s):  
María Julia Zanini ◽  
Carla Domínguez ◽  
Toni Fernández-Oliva ◽  
Olga Sánchez ◽  
María Torres Toda ◽  
...  
Keyword(s):  
Environmental Exposures ◽  
Placental Development ◽  
Exposures During Pregnancy

scholarly journals Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e034702
Author(s):  
Wilco Zijlmans ◽  
Jeffrey Wickliffe ◽  
Ashna Hindori-Mohangoo ◽  
Sigrid MacDonald-Ottevanger ◽  
Paul Ouboter ◽  
...  
Keyword(s):  
Cohort Study ◽  
Occupational Health ◽  
Pregnant Women ◽  
Fish Consumption ◽  
Depression Scale ◽  
Environmental Exposures ◽  
International Standards ◽  
Long Term Effects ◽  
The Impact ◽  
Environmental And Occupational Health

PurposeThe Caribbean Consortium for Research in Environmental and Occupational Health prospective environmental epidemiologic cohort study addresses the impact of chemical and non-chemical environmental exposures on mother/child dyads in Suriname. The study determines associations between levels of environmental elements and toxicants in pregnant women, and birth outcomes and neurodevelopment in their children.ParticipantsPregnant women (N=1143) were enrolled from December 2016 to July 2019 from three regions of Suriname: Paramaribo (N=738), Nickerie (N=204) and the tropical rainforest interior (N=201). Infants (N=992) were enrolled at birth. Follow-up will take place until children are 48 months old.Findings to dateBiospecimens and questionnaire data on physiological and psychosocial health in pregnant women have been analysed. 39.1% had hair mercury (Hg) levels exceeding values considered safe by international standards. Median hair Hg concentrations in women from Paramaribo (N=522) were 0.64 µg/g hair (IQRs 0.36–1.09; range 0.00–7.12), from Nickerie (N=176) 0.73 µg/g (IQR 0.45–1.05; range 0.00–5.79) and the interior (N=178) 3.48 µg/g (IQR 1.92–7.39; range 0.38–18.20). 96.1% of women ate fish, respective consumption of the three most consumed carnivorous species, Hoplias aimara, Serrasalmus rhombeus and Cichla ocellaris, known to have high Hg levels, was 44.4%, 19.3% and 26.3%, respectively, and was greater among the interior subcohort. 89% frequently consumed the vegetable tannia, samples of which showed presence of worldwide banned pesticides. 24.9% of pregnant women had Edinburgh Depression Scale scores indicative of probable depression.Future plansFish consumption advisories are in development, especially relevant to interior women for whom fish consumption is likely to be the primary source of Hg exposure. Effects of potentially beneficial neuroprotective factors in fish that may counter neurotoxic effects of Hg are being examined. A pesticide literacy assessment in pregnant women is in progress. Neurodevelopmental assessments and telomere length measurements of the children to evaluate long-term effects of prenatal exposures to toxicant mixtures are ongoing.

scholarly journals Symposium report: breast cancer in India—trends, environmental exposures and clinical implications

2021 ◽  
Vol 32 (6) ◽  
pp. 567-575
Author(s):  
Jasmine A. McDonald ◽  
Roshni Rao ◽  
Marley Gibbons ◽  
Rajiv Janardhanan ◽  
Surinder Jaswal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Environmental Exposures ◽  
Population Based ◽  
Clinical Implications ◽  
Think Tank ◽  
Case Control Studies ◽  
Short Term

Abstract Purpose Incidence of breast cancer (BC), particularly in young women, are rising in India. Without population-based mammography screening, rising rates cannot be attributed to screening. Investigations are needed to understand the potential drivers of this trend. Methods An international team of experts convened to discuss the trends, environmental exposures, and clinical implications associated with BC in India and outlined recommendations for its management. Results Panels were structured across three major BC themes (n = 10 presentations). The symposium concluded with a semi-structured Think Tank designed to elicit short-term and long-term goals that could address the challenges of BC in India. Conclusion There was consensus that the prevalence of late-stage BC and the high BC mortality rates are associated with the practice of detection, which is primarily through clinical and self-breast exams, as opposed to mammography. Triple-Negative BC (TNBC) was extensively discussed, including TNBC etiology and potential risk factors, the limited treatment options, and if reported TNBC rates are supported by rigorous scientific evidence. The Think Tank session yielded long-term and short-term goals to further BC reduction in India and included more regional etiological studies on environmental exposures using existing India-based cohorts and case–control studies, standardization for molecular subtyping of BC cases, and improving the public’s awareness of breast health.

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