Quantification and prediction of skin pharmacokinetics of amoxicillin and cefuroxime

2009 ◽  
Vol 30 (6) ◽  
pp. 281-293 ◽  
Author(s):  
Chinmay Shukla ◽  
Vishal Patel ◽  
Ravi Juluru ◽  
Grazia Stagni
Keyword(s):  
Skin Pharmacokinetics

Skin Pharmacokinetics

1988 ◽  
Vol 27 (6) ◽  
pp. 351-359 ◽  
Author(s):  
H. Schaefer ◽  
J. C. Jamoulle
Keyword(s):  
Skin Pharmacokinetics

scholarly journals Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis

2017 ◽  
Vol 62 (3) ◽  
Author(s):  
Gert-Jan Wijnant ◽  
Katrien Van Bocxlaer ◽  
Vanessa Yardley ◽  
Andy Harris ◽  
Sudaxshina Murdan ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Parasite Load ◽  
Lesion Size ◽  
Clear Correlation ◽  
Relative Reduction ◽  
Multiple Dosing ◽  
Content Type ◽  
Drug Levels ◽  
Skin Pharmacokinetics

ABSTRACTAmBisome (LAmB), a liposomal formulation of amphotericin B (AmB), is a second-line treatment for the parasitic skin disease cutaneous leishmaniasis (CL). Little is known about its tissue distribution and pharmacodynamics to inform clinical use in CL. Here, we compared the skin pharmacokinetics of LAmB with those of the deoxycholate form of AmB (DAmB; trade name Fungizone) in murine models ofLeishmania majorCL. Drug levels at the target site (the localized lesion) 48 h after single intravenous (i.v.) dosing of the individual AmB formulations (1 mg/kg of body weight) were similar but were 3-fold higher for LAmB than for DAmB on day 10 after multiple administrations (1 mg/kg on days 0, 2, 4, 6, and 8). After single and multiple dosing, intralesional concentrations were 5- and 20-fold, respectively, higher than those in the healthy control skin of the same infected mice. We then evaluated how drug levels in the lesion after LAmB treatment relate to therapeutic outcomes. After five administrations of the drug at 0, 6.25, or 12.5 mg/kg (i.v.), there was a clear correlation between dose level, intralesional AmB concentration, and relative reduction in parasite load and lesion size (R2values of >0.9). This study confirms the improved efficacy of the liposomal over the deoxycholate AmB formulation in experimental CL, which is related to higher intralesional drug accumulation.

Skin pharmacokinetics

Toxicon ◽  
1989 ◽  
Vol 27 (3) ◽  
pp. 400
Author(s):  
F. Kornalik
Keyword(s):  
Skin Pharmacokinetics

Gamithromycin plasma and skin pharmacokinetics in sheep

2014 ◽  
Vol 97 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Michael Kellermann ◽  
Rose A. Huang ◽  
Andrew B. Forbes ◽  
Steffen Rehbein
Keyword(s):  
Skin Pharmacokinetics

Skin Pharmacokinetics of Transdermal Scopolamine: Measurements and Modeling

2021 ◽  
Author(s):  
Andrea Pensado ◽  
Laura Hattam ◽  
K. A. Jane White ◽  
Anita McGrogan ◽  
Annette L. Bunge ◽  
...  
Keyword(s):  
Skin Pharmacokinetics
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