The relationships between half-life(t1/2) and mean residence time(MRT) in the two-compartment open body model

2004 ◽  
Vol 25 (4) ◽  
pp. 157-162 ◽  
Author(s):  
Eyal Sobol ◽  
Meir Bialer
Keyword(s):  
Residence Time ◽  
Mean Residence Time ◽  
Half Life ◽  
Body Model

scholarly journals Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance

Haematologica ◽  
2021 ◽  
Author(s):  
Soracha E. Ward ◽  
Jamie M. O’Sullivan ◽  
Alan B. Moran ◽  
Daniel I. R. Spencer ◽  
Richard A. Gardner ◽  
...  
Keyword(s):  
Residence Time ◽  
Von Willebrand Factor ◽  
Mean Residence Time ◽  
Half Life ◽  
Fold Increase ◽  
Von Willebrand ◽  
Willebrand Factor

Terminal sialylation determines plasma VWF half-life. A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we show that MGL influences physiological plasma VWF clearance. MGL inhibition was associated with a significantly extended mean residence time and 3-fold increase in endogenous plasma VWF:Ag levels (p

scholarly journals Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed Aboubakr ◽  
Ahmed Soliman
Keyword(s):  
Serum Concentration ◽  
Oral Administration ◽  
Residence Time ◽  
Mean Residence Time ◽  
Half Life ◽  
Pharmacokinetic Profile ◽  
Total Clearance ◽  
Elimination Half ◽  
Muscovy Ducks ◽  
Intravenous And Oral Administration

The pharmacokinetics aspects of levofloxacin were studied in healthy and experimentally renal damaged Muscovy ducks after single intravenous (IV) and oral (PO) dose of 10 mg kg−1 bwt. Following IV administration, elimination half-life (t1/2(β)) and mean residence time (MRT) were longer in renal damaged ducks than in healthy ones. Total clearance(Cltot)in renal damaged ducks (0.20 L kg−1 h−1) was significantly lower as compared to that in healthy ones (0.41 L kg−1 h−1). Following PO administration, the peak serum concentration(Cmax)was higher in renal damaged than in healthy ducks and was achieved at maximum time(tmax)of 2.47 and 2.05 h, respectively. The drug was eliminated (t1/2(el)) at a significant slower rate (3.94 h) in renal damaged than in healthy ducks (2.89 h). The pharmacokinetic profile of levofloxacin is altered in renal damaged ducks due to the increased serum levofloxacin concentrations compared with that in clinically healthy ducks. Oral administration of levofloxacin at 10 mg kg−1 bwt may be highly efficacious against susceptible bacteria in ducks. Also, the dose of levofloxacin should be reduced in renal damaged ducks. Pharmacokinetic/pharmacodynamic integration revealed significantly higher values forCmax/MIC and AUC/MIC ratios in renal damaged ducks than in healthy ones, indicating the excellent pharmacokinetic characteristics of levofloxacin in renal damaged ducks.

Precipitation and filtration of zinc, magnesium, copper and aluminium hydroxides

1982 ◽  
Vol 47 (12) ◽  
pp. 3362-3370
Author(s):  
Otakar Söhnel ◽  
Eva Matějčková
Keyword(s):  
Residence Time ◽  
Mean Residence Time ◽  
Filtration Resistance ◽  
Filtration Pressure ◽  
Bed Porosity ◽  
The Mean ◽  
Filtration Properties

Filtration properties of batchwise precipitated suspensions of Zn(OH)2, Mg(OH)2 and Cu(OH)2 and continuously precipitated Al(OH)3 were studied. For batchwise precipitated suspensions was verified the theoretically predicted dependence of specific filtration resistance on initial supersaturation and for the continuously precipitated Al(OH)3 the relation between the specific filtration resistance and the mean residence time of suspension in the reactor. Dependences were also recorded between the bed porosity and concentration of precipitated solutions, specific filtration resistance and used filtration pressure and the effect of aging of the batchwise precipitated suspension of Mg(OH)2on its filtration properties. The used CST method for determination of filtration characteristics of Zn(OH)2 suspension was also studied.

Nitrogen use efficiency: does a trade-off exist between the N productivity and the mean residence time within species?

2008 ◽  
Vol 56 (3) ◽  
pp. 272 ◽  
Author(s):  
Zhi Y. Yuan ◽  
Han Y. H. Chen ◽  
Ling H. Li
Keyword(s):  
Residence Time ◽  
Nitrogen Use Efficiency ◽  
Mean Residence Time ◽  
Negative Relationship ◽  
Controlled Experiments ◽  
Nitrogen Use ◽  
Trade Off ◽  
N Supply ◽  
Use Efficiency ◽  
The Mean

Nitrogen use efficiency (NUE) can be divided into two components, i.e. N productivity (A) and the mean residence time (MRT). Controlled experiments indicate that there is not a trade-off between A and MRT within species, but this theory has not been well tested in field conditions. Here, we studied the A, MRT and NUE of Stipa krylovii Roshev. in a grassland over 4 years of N fertilisation experimentation. The three parameters (A, MRT and NUE) were significantly related to soil N supply and there was a negative relationship between A and MRT within this species (r = –0.775, P < 0.05), i.e. plants with higher A had lower MRT. Our results showed a trade-off between A and MRT within this Stipa species and this observed trade-off was attributed to different responses of A and MRT to soil fertility.

scholarly journals Struvite recovery from solution containing phosphate(V) and sulphate(VI) ions

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Nina Hutnik ◽  
Anna Kozik ◽  
Krzysztof Piotrowski ◽  
Andrzej Matynia
Keyword(s):  
Product Quality ◽  
Constant Temperature ◽  
Residence Time ◽  
Mean Residence Time ◽  
Crystallization Process ◽  
Magnesium Ions ◽  
Ammonium Ions ◽  
Internal Circulation ◽  
Mean Size ◽  
Type Crystallizer

AbstractThe research results concerning the application of magnesium and ammonium ions for continuous removal of phosphate(V) ions from solution containing 1.0 or 0.20 mass% of PO43– and from 0.10 to 0.50 mass% of SO42– are presented. A continuous struvite MgNH4PO4 × 6H2O reaction crystallization process was carried out both under stoichiometric conditions and using 20% excess of magnesium ions. The research was conducted in a DT MSMPR type crystallizer with internal circulation of suspension driven by a propeller stirrer, in constant temperature 298 K. The pH varied from 9 to 11 and mean residence time of suspension in a crystallizer τ varied from 900 to 3600 s. It was concluded, that sulphate(VI) ions influenced product quality disadvantageously. Depending on process parameter combinations struvite crystals of mean size from ca. 18 to ca. 44 μm and of moderate homogeneity: CV 7–95% were produced. Presence of sulphate(VI) ions favored crystallization of struvite as prismatic crystals, but tubular forms were also identified. The best shaped struvite crystals were produced at relatively low concentration of sulphate(VI) ions, pH 9 and for mean residence time of suspension in a crystallizer elongated up to 3600 s.

Mean Residence Time of a Liquid in a Trickling Filter

1959 ◽  
Vol 85 (6) ◽  
pp. 51-78 ◽  
Author(s):  
Morton D. Sinkoff ◽  
Ralph Porges ◽  
James H. McDermott
Keyword(s):  
Residence Time ◽  
Mean Residence Time ◽  
Trickling Filter
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