Pharmacokinetic characterization of a human immunodeficiency virus protease inhibitor, saquinavir, during ethanol intake in rats

2003 ◽  
Vol 24 (8) ◽  
pp. 335-344 ◽  
Author(s):  
Nobuhito Shibata ◽  
Michiharu Kageyama ◽  
Tomoyuki Kishida ◽  
Keisuke Kimura ◽  
Yukako Yoshikawa ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Protease Inhibitor ◽  
Ethanol Intake ◽  
Human Immunodeficiency Virus Protease ◽  
Immunodeficiency Virus

Effect of a Human Immunodeficiency Virus Protease Inhibitor on Human Monocyte Function

1992 ◽  
Vol 8 (12) ◽  
pp. 1951-1958 ◽  
Author(s):  
PETER J. BUGELSKI ◽  
JOHANNE M. KAPLAN ◽  
TIMOTHY K. HART ◽  
JOANNE MILLER ◽  
JEFFERY T. LAYDON ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Protease Inhibitor ◽  
Human Monocyte ◽  
Human Immunodeficiency Virus Protease ◽  
Monocyte Function ◽  
Immunodeficiency Virus

Detection of Indinavir Crystals in Urine

2000 ◽  
Vol 124 (2) ◽  
pp. 246-250
Author(s):  
Glen L. Hortin ◽  
Christine King ◽  
Kirk D. Miller ◽  
Jeffrey B. Kopp
Keyword(s):  
Human Immunodeficiency Virus ◽  
Specific Gravity ◽  
Protease Inhibitor ◽  
Detection Rates ◽  
Human Immunodeficiency Virus Protease ◽  
Immunodeficiency Virus ◽  
Urine Specimens

Abstract Objectives.—To determine the frequency of crystalluria in patients treated with the human immunodeficiency virus protease inhibitor indinavir and to compare methods of detecting crystalluria. Methods.—A total of 308 freshly voided urine specimens from 168 patients treated with indinavir were evaluated by manual microscopy of sediment and microscopy with an automated workstation and by dipstick analysis. Results.—Crystals were detected in 22%, 31%, or 32% of specimens using, respectively, an automated workstation, manual microscopy, or both methods. Proteinuria or hemoglobinuria occurred significantly more often in specimens with (28%) than without (18%) crystals. Frequency of crystalluria was unrelated to specific gravity, but it increased at higher pH. Crystals were detected in 21% of specimens with pH less than 6 and 42% of specimens with pH of 6 or higher. Conclusions.—Crystalluria occurs in more than 30% of urine specimens from patients treated with indinavir, but detection rates vary substantially with method of analysis. Manual microscopy detected crystalluria 41% more often than did an automated workstation.

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