Evaluation of SupermixTM as anin vitro model of human liver microsomal drug metabolism

2002 ◽  
Vol 23 (5) ◽  
pp. 183-190 ◽  
Author(s):  
Karthik Venkatakrishnan ◽  
Lisa L. von Moltke ◽  
David J. Greenblatt
Keyword(s):  
Drug Metabolism ◽  
Human Liver ◽  
Microsomal Drug Metabolism ◽  
Vitro Model

Ketamine as a Probe for Medetomidine Stereoisomer Inhibition of Human Liver Microsomal Drug Metabolism

1992 ◽  
Vol 77 (6) ◽  
pp. 1208-1214 ◽  
Author(s):  
Evan D. Kharasch ◽  
Susan Herrmann ◽  
Rita Labroo
Keyword(s):  
Drug Metabolism ◽  
Human Liver ◽  
Microsomal Drug Metabolism

Human liver microsomal drug metabolism

1970 ◽  
Vol 19 (4) ◽  
pp. 1514-1517 ◽  
Author(s):  
F.J. Darby ◽  
W. Newnes ◽  
D.A. Price Evans
Keyword(s):  
Drug Metabolism ◽  
Human Liver ◽  
Microsomal Drug Metabolism

scholarly journals Crypt Organoid Culture as an In Vitro Model in Drug Metabolism and Cytotoxicity Studies

2017 ◽  
Vol 45 (7) ◽  
pp. 748-754 ◽  
Author(s):  
Wenqi Lu ◽  
Eva Rettenmeier ◽  
Miles Paszek ◽  
Mei-Fei Yueh ◽  
Robert H. Tukey ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
In Vitro Model ◽  
Organoid Culture ◽  
Cytotoxicity Studies ◽  
Vitro Model

Inhibition of Hepatic Microsomal Drug Metabolism by the Hydrazines Ro 4-4602, MK 486, and Procarbazine Hydrochloride

1972 ◽  
Vol 50 (7) ◽  
pp. 721-724 ◽  
Author(s):  
Norman R. Bade ◽  
Stuart M. MacLeod ◽  
Kenneth W. Renton
Keyword(s):  
Drug Interaction ◽  
Drug Metabolism ◽  
Sleeping Time ◽  
Hydrazine Derivatives ◽  
Significant Drug Interaction ◽  
Microsomal Drug Metabolism ◽  
Clinically Significant ◽  
Hepatic Biotransformation

Preliminary experiments were undertaken to examine the effect of three hydrazine derivatives, viz. Ro 4-4602, MK 486, and procarbazine hydrochloride, on hepatic microsomal drug metabolism in rats. All three compounds when given as pretreatment significantly prolonged pentobarbital sleeping time. In vitro, the hepatic microsomal N-demethylation of aminopyrine was inhibited. It is concluded that all three drugs are possible sources of clinically significant drug interaction when administered in combination with other agents which undergo hepatic biotransformation.

An in vitro model of warm hypoxia–reoxygenation injury in human liver endothelial cells

2012 ◽  
Vol 178 (1) ◽  
pp. e35-e41 ◽  
Author(s):  
Neal R. Banga ◽  
K. Raj Prasad ◽  
J. Lance Burn ◽  
Shervanthi Homer-Vanniasinkam ◽  
Anne Graham
Keyword(s):  
Endothelial Cells ◽  
Human Liver ◽  
In Vitro Model ◽  
Reoxygenation Injury ◽  
Liver Endothelial Cells ◽  
Vitro Model ◽  
Hypoxia Reoxygenation

Stress-induced alterations in microsomal drug metabolism in the rat

1967 ◽  
Vol 16 (8) ◽  
pp. 1489-1494 ◽  
Author(s):  
Robert E. Stitzel ◽  
Raymond L. Furnbr
Keyword(s):  
Drug Metabolism ◽  
Microsomal Drug Metabolism
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