Mean residence time of drugs administered non-instantaneously and undergoing linear tissue distribution and reversible metabolism and linear or non-linear elimination from the central compartment

1995 ◽  
Vol 16 (4) ◽  
pp. 259-267 ◽  
Author(s):  
Haiyung Cheng
1994 ◽  
Vol 15 (8) ◽  
pp. 627-641 ◽  
Author(s):  
Haiyung Cheng ◽  
William R. Gillespie ◽  
William J. Jusko

1993 ◽  
Vol 39 (132) ◽  
pp. 409-414 ◽  
Author(s):  
Angela M. Gurnell

Abstract Analysis of hydrograph-recession curves from temperate catchments has frequently been directed towards identifying a linear-storage element with mean residence time Κ which characterizes the delayed-flow component. This paper presents the results of applying such an analysis to recession curves from 11 years of discharge records from a glacier basin. Four reservoirs are identified but their estimated recession coefficients (K values) are found to vary with discharge and with time in the ablation season. This implies that the reservoirs are non-linear. Whilst it may be helpful for the interpretation of glacier-hydrological processes to identify several reservoirs, it appears that a single non-linear reservoir may provide an adequate representation of the glacier for operational forecasting purposes.


1993 ◽  
Vol 39 (132) ◽  
pp. 409-414 ◽  
Author(s):  
Angela M. Gurnell

AbstractAnalysis of hydrograph-recession curves from temperate catchments has frequently been directed towards identifying a linear-storage element with mean residence time Κ which characterizes the delayed-flow component. This paper presents the results of applying such an analysis to recession curves from 11 years of discharge records from a glacier basin. Four reservoirs are identified but their estimated recession coefficients (K values) are found to vary with discharge and with time in the ablation season. This implies that the reservoirs are non-linear. Whilst it may be helpful for the interpretation of glacier-hydrological processes to identify several reservoirs, it appears that a single non-linear reservoir may provide an adequate representation of the glacier for operational forecasting purposes.


1982 ◽  
Vol 47 (12) ◽  
pp. 3362-3370
Author(s):  
Otakar Söhnel ◽  
Eva Matějčková

Filtration properties of batchwise precipitated suspensions of Zn(OH)2, Mg(OH)2 and Cu(OH)2 and continuously precipitated Al(OH)3 were studied. For batchwise precipitated suspensions was verified the theoretically predicted dependence of specific filtration resistance on initial supersaturation and for the continuously precipitated Al(OH)3 the relation between the specific filtration resistance and the mean residence time of suspension in the reactor. Dependences were also recorded between the bed porosity and concentration of precipitated solutions, specific filtration resistance and used filtration pressure and the effect of aging of the batchwise precipitated suspension of Mg(OH)2on its filtration properties. The used CST method for determination of filtration characteristics of Zn(OH)2 suspension was also studied.


2008 ◽  
Vol 56 (3) ◽  
pp. 272 ◽  
Author(s):  
Zhi Y. Yuan ◽  
Han Y. H. Chen ◽  
Ling H. Li

Nitrogen use efficiency (NUE) can be divided into two components, i.e. N productivity (A) and the mean residence time (MRT). Controlled experiments indicate that there is not a trade-off between A and MRT within species, but this theory has not been well tested in field conditions. Here, we studied the A, MRT and NUE of Stipa krylovii Roshev. in a grassland over 4 years of N fertilisation experimentation. The three parameters (A, MRT and NUE) were significantly related to soil N supply and there was a negative relationship between A and MRT within this species (r = –0.775, P < 0.05), i.e. plants with higher A had lower MRT. Our results showed a trade-off between A and MRT within this Stipa species and this observed trade-off was attributed to different responses of A and MRT to soil fertility.


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